Abstract: The invention provides a compound of formula (I) and processes for the manufacture of such compounds, related intermediates, compositions comprising such compounds and the use of such compounds as cytidine triphosphate synthase 1 inhibitors, particularly in the treatment or prophylaxis of disorders associated with cell proliferation.

Abstract: A method includes identifying, using at least one processor, a first point associated with an uncertain location of an object in a space and a polynomial curve associated with an uncertain location of a feature in the space. The method also includes determining, using the at least one processor, a probabilistic proximity of the object and the feature. The probabilistic proximity is determined by identifying a second point on the polynomial curve, transforming an uncertainty associated with the polynomial curve into an uncertainty associated with the second point, and identifying the probabilistic proximity of the object and the feature using the first and second points and the uncertainty associated with the second point.

Abstract: A system and method are disclosed for computing a Health Score. Health data and extrinsic data are received that are parameters for computation of the Health Score. The received data can be combined using an algorithm being implemented as code executing in a processor so as to compute the Health Score of the individual wherein parameters comprising one portion of the data interacts with parameters comprising another portion of the data. Further, the computed Health Score is output to an interface of the user device. Information concerning the parameters' interaction are selectively output to the interface that explain which changes in the parameters are significant drivers of the change in the Health Score.

Abstract: Systems and methods use ion exchange to extract lithium from a lithium-containing feed solution such as a salar brine. Lithium ions are loaded into an ion exchange resin and then eluted while recharging the resin. Sodium hydroxide or sodium bicarbonate may be used to recharge the resin but are not directly mixed with the lithium-containing feed solution. An eluate stream is produced containing lithium hydroxide or lithium bicarbonate. Lithium hydroxide can be precipitated as lithium hydroxide or in a hydrate form. Lithium bicarbonate may be converted to lithium carbonate. The system and method optionally includes processing an eluate stream to recover one or more compounds for re-use in regenerating the resin bed.

Abstract: The invention relates to methods and agents useful for treating motor neuron diseases (MNDs), in particular, amyotrophic lateral sclerosis (ALS). Methods and agents for treating various physiological and pathological conditions associated with motor neuron diseases are also provided.

Abstract: A pagewide printhead for redundant printing has first and second rows of printhead chips mounted on a common ink manifold. The ink manifold has four ink supply channels for supplying ink to the first and second rows of printhead chips. Dedicated ink outlets interconnect one ink supply channel of the ink manifold with two color channels in each printhead chip.

Abstract: Unmanned Aerial Vehicles also known as UAVs or Drones, either autonomous or remotely piloted, are classified as drones by the US Federal Aviation Administration (FAA) as weighing under 212 pounds. The system described herein details Autonomous Flight Vehicles (AFV) which weigh over 212 pounds but less than 1,320 pounds which may require either a new classification or a classification such as Sport Light Aircraft, but without the requirement of a pilot due to the safe autonomous flight system such as the Safe Temporal Vector Integration Engine or STeVIE. Safe Autonomous Light Aircraft (SALA) are useful as drone carriers, large scale air package or cargo transport, and even human transport depending on the total lift capability of the platform.

Abstract: Methods and apparatus are disclosed for the maintenance of a virtual credit card pool for airline passenger vouchers. An example system includes server(s) that are configured to determine a target distribution of virtual credit cards within the virtual card pool for a current date-and-time. The server(s) are configured to, in response to determining that the current date-and-time corresponds with a predefined restocking time, for each card value: identify a current number of virtual credit cards within the virtual card pool; identify a threshold number of virtual credit cards based on the target distribution; compare the current and threshold numbers; in response to determining that the current number is less than the threshold number, transmit a request for virtual credit cards having the card value to an external server; and add the requested virtual credit cards to the virtual card pool upon receipt.

Abstract: A system such as a vehicle may have adjustable structures such as adjustable windows. Adjustable windows may have adjustable layers such as adjustable tint layers, adjustable reflectivity layers, and adjustable haze layers. Adjustable window layers may be incorporated into a window with one or more transparent structural layers such as a pair of glass window layers. Adjustable components such as adjustable reflectivity layers, adjustable haze layers, and adjustable tint layers may be interposed between the pair of glass window layers. Fixed partially reflective mirrors, fixed tint layers, and/or fixed haze layers may be used in place of adjustable tint, haze, and reflectivity layers and/or may be incorporated into windows in addition to adjustable tint, haze, and reflectivity layers.

Abstract: This invention relates to compounds of formula (I) and methods of treatment using the compounds. The compounds of the invention can be used in combination with antibacterial agents to treat bacterial infections. More specifically, the compounds of formula (I) can be used in combination with a class of antibacterial agents known as carbapenems. The novel compounds of the present invention are enzyme inhibitors and more particularly are metallo-?-lactamase inhibitors.

Abstract: A method may select a surviving storage node based on environmental conditions. A request for exclusive access to a volume is received. A score based on data associated with an environment of the node is determined for each node in a cluster. Based on the scores, a node to grant exclusive access to the volume is identified, and such exclusive access is granted to the identified node.

Abstract: A novel maize variety designated 1PAKH79 and seed, plants and plant parts thereof are provided. Methods for producing a maize plant comprise crossing maize variety 1PAKH79 with another maize plant are provided. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into 1PAKH79 through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby are provided. Hybrid maize seed, plants or plant parts are produced by crossing the variety 1PAKH79 or a locus conversion of 1PAKH79 with another maize variety.

Abstract: The present disclosure is directed to a system and method for selectively and reversibly modulating targeted neural and non-neural tissue of a nervous system for the treatment of pain. An electrical stimulation is delivered to the treatment site that selectively and reversibly modulates the targeted neural- and non-neural tissue of the nervous structure, inhibiting pain while preserving other sensory and motor function, and proprioception.

Abstract: The present disclosure is directed to systems and methods for operating a grading machine. The method includes (i) receiving information indicating a current position of a moldboard of the grading machine; (ii) determining if the moldboard is moving toward an avoidance zone, and the avoidance zone is defined by a distance from a scarifier of the grading machine; and (iii) in response to a determination that the moldboard is moving toward the avoidance zone, adjusting at least one operating parameter of the moldboard or the scarifier of the grading machine.

Abstract: A dental appliance having an integrally formed reservoir and/or an ornamental design integrated thereon. The ornamental design can be selected or customized by a patient. The design can be created by directing energy to the dental appliance to alter a material property of at least a portion of the appliance to create the design. Alternatively, a groove or recess can be formed on a surface of the appliance to either mechanically retain an ornamental design or the groove or recess can be filled with ink to form the design. The appliance, including the integrally formed reservoir, can be formed using direct fabrication techniques.

Abstract: A computer implemented method for controlling an ultrasonic surgical system includes activating an ultrasonic surgical system including an ultrasonic generator, an ultrasonic transducer, and an ultrasonic blade. The method further includes collecting data from the ultrasonic surgical system, communicating the data to a machine learning algorithm, determining the vessel size based on the data, using the machine learning algorithm, communicating the determined vessel size to a computing device associated with the ultrasonic generator, and controlling the activated ultrasonic surgical system in accordance with the vessel size. The data may include an electrical parameter associated with the activated ultrasonic surgical system. When the ultrasonic surgical system is activated, the ultrasonic generator produces a drive signal to drive the ultrasonic transducer which, in turn, produces ultrasonic energy that is transmitted to the ultrasonic blade for treating a vessel in contact with the ultrasonic blade.

Abstract: A plurality of air bags is provided as part of a child safety seat for use in a vehicle. The decompressed external air bag extends outwardly from a wing of the seat and transfers an air volume to the initially compressed internal bag, causing it to inflate and cushion the head and/or upper body of the occupant of the safety seat. When installed in a vehicle the seat equipped with air bags serves to mitigate any free flight zones during a collision, increase ride down time, and allow early loading onset, and thereby improve the safety of the occupant. The external airbag may be adjustable for tailoring the safety seat to the vehicle dimensions and being collapsible for stowage.

Abstract: A media sharing and communication system, including a recording mechanism that records a desired portion of media upon activation by a first individual user, a first user transmitter/receiver that transmits the portion of media and a message generated by the first individual user regarding the portion of media to a second individual user and is capable of transmitting a message to a second individual user, a confirmation mechanism that confirms that the second individual user is authorized to view the portion of media, a notification mechanism that notifies the first individual user if the second individual user is not authorized to receive the portion of media, a second user transmitter/receiver that receives the portion of media and voice message upon authorization of the second individual user, a search mechanism, and a video recording mechanism, an online betting module, and an online food ordering module.

Abstract: An apparatus for mounting within a vehicle, an object having at least one receptacle in a first main surface. The apparatus comprises a base having a mounting surface. A latch and a frame are movable between latched and unlatched positions and are biased toward the latched position by a first biasing element. One or more push buttons are movable between extended and depressed positions and are biased toward the extended position by a second biasing element. A lower portion of the push button blocks and allows movement of the frame toward the latched position when the push button is in the extended and depressed position, respectively. The first main surface pushes the push button to the depressed position, thereby enabling the first biasing element to move the latch and the frame to the latched position, in which the latch engages with the at least one receptacle.

Abstract: A combination is provided including lighting apparatus and a baffle assembly. The lighting apparatus comprises a frame and a light source. The baffle assembly comprises a plurality of sound dampening baffles that can be attached to the frame and help dampen sound near the lighting apparatus.