Abstract: The present invention concerns novel pharmaceutically active triterpene amine derivatives, pharmaceutical compositions containing the same, their use as medicaments, and the use of the compounds for the manufacture of specific medicaments. The present invention also concerns a method of treatment involving administration of the triterpene amine compounds. Specifically, the compounds are derivatives of betulinic acid having substitutions at one or more of the C-3, C-28 and C-19 positions as further described herein. The novel compounds are useful as antiretroviral agents. In particular, the novel compounds are useful for the treatment of Human Immunodeficiency Virus-1 (HIV-1).

Abstract: This disclosure describes an apparatus and method of an embodiment of an invention that is a band-limited beamforming microphone array with acoustic echo cancellation that includes: a plurality of first microphones configured as a beamforming microphone array to resolve first audio input signals within a first frequency range, the beamforming microphone array includes acoustic echo cancellation; one or more additional microphone(s) configured to resolve second audio input signals within a restricted second frequency range such that the additional microphone(s) are coupled to the beamforming microphone array; augmented beamforming that processes audio signals from the beamforming microphone array and the additional microphone(s).

Abstract: A system, such as an IMD system, includes a tissue conductance communication (TCC) transmitter configured to generate a beacon signal by generating a carrier signal and modulating a first property of the carrier signal according to a first type of modulation. The TCC transmitter is configured to generate a data signal subsequent to the beacon signal by generating the carrier signal and modulating a second property of the carrier signal different than the first property according to a second type of modulation different than the first type of modulation.

Abstract: A golf club head includes a face; a body, the body defining an interior and an exterior; the face and the body together defining a center of gravity, the center of gravity being proximate the face; a coefficient of restitution feature defined in the body; wherein the coefficient of restitution feature defines a gap in the body. A golf club head includes a face and a golf club body; the face and the golf club body defining a center of gravity, the center of gravity defined a distance, ?z, from a ground plane as measured along a z-axis, the center of gravity defined a distance, CGy, from the center face along the y-axis.

Abstract: An electronic device identifier mapping and resolution system are disclosed which may be used to analyze various device identifiers associated with an online event initiated by a particular device in applying a matching algorithm to determine a unique device identifier and/or device profile for the device. Device identifiers provided from disparate sources (such as web browser cookies, network IP addresses, device-specific identifiers, application-specific identifiers, custom identifiers, probabilistic identifiers, etc.), including both deterministic and/or probabilistic identifiers, may be analyzed according to the matching algorithm to determine a device identifier associated with the device. Matching algorithms may be customized and configured to a high degree of complexity for respective entities, such as to analyze disparate device identifiers according to a variety of identifier comparison functions and matching tiers.

Abstract: The present disclosure provides compositions and methods for rapid production of chemicals in genetically engineered microorganisms in a large scale. Also provided herein is a high-throughput metabolic engineering platform enabling the rapid optimization of microbial production strains. The platform, which bridges a gap between current in vivo and in vitro bio-production approaches, relies on dynamic minimization of the active metabolic network.

Abstract: The present application provides compounds that modulate CDK protein function. Methods of making the compounds, compositions containing the compounds, and uses of the compounds for treating or ameliorating of diseases, disorders, or conditions associated with CDK proteins, are also disclosed.

Abstract: Disclosed examples include lens cleaning systems, drivers and operating methods, including a transducer mechanically coupled to a lens, a driver to provide an oscillating drive signal to the transducer and a controller to control the drive signal frequency to vibrate the lens at frequencies in a range of interest. The controller determines a measured resonant frequency of the lens cleaning system in the range of interest according to a transducer feedback signal and selectively performs a lens cleaning operation if the measured resonant frequency differs from a baseline resonant frequency of the lens cleaning system for a clean lens.

Abstract: The invention provides a method of treating cancer in a subject in need thereof, comprising administering to the subject: (a) a compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein R is hydrogen or an acyl group; and (b) a PD-1 signaling inhibitor; wherein the compound of Formula I or pharmaceutically acceptable salt thereof and the PD-1 signaling inhibitor are administered in amounts which in combination are therapeutically effective. The invention further provides a pharmaceutical composition comprising a compound of Formula I or a pharmaceutically acceptable salt thereof, a PD-1 signaling inhibitor and a pharmaceutically acceptable carrier or excipient.

Abstract: An approach is provided for using a single-entry access point to archive data in and out of an electronic document review and reporting system. In an embodiment, a method comprises receiving, by a data access system, a request for data and parsing the request to determine a request type of the request. Based on the request type, particular data is determined and accessed from either the data access system or a document review and reporting system. Based on the particular data, the data access system generates one or more of: particular review analysis data, particular reporting data, or particular specific data. The particular review analysis data includes one or more of: a review progress summary, a review analysis report, a review analysis summary, or a review analysis job report. The particular reporting data includes one or more of: a global trend report, a statistical report, or an executive summary.

Abstract: Apparatus, system and method for medical analysis of a seated individual, includes determining the aortic valve opening; the PTT; and calculating the PWV. Determining the aortic valve opening includes collecting BCG data while sitting on a seat and determining the timing of the aortic valve opening, taking into account posture. Measuring the aortic pulse wave transit time includes collecting BCG data while sitting on a seat capable of measuring changes in apparent weight; determining the timing of the aortic valve opening; detecting the arrival of the pulse wave at the end point; and measuring the relative timings of the two events. Calculating the PWV includes determining a length of the arterial segment through which a pulse wave is to be measured between a start point and an end point; and dividing the determined length of the arterial segment by the PTT.

Abstract: The present disclosure relates generally to flame retarding building materials and methods for making them. More particularly, the present disclosure relates to flame retarding building materials that have both flame retardant character and desirable water vapor permeability values. In one embodiment, the disclosure provides a flame retardant vapor retarding membranes comprising: a building material substrate sheet having a melt viscosity of about 1 Pa·s to about 100,000 Pa·s at about 300° C. at 1 rad/s; and a polymeric coating layer disposed on the building material substrate layer, wherein the coating layer has a melt viscosity of about 1 Pa·s to about 100,000 Pa·s at about 300° C. at 1 rad/s.

Abstract: Distance measuring devices and methods are included which may be used to measure and simultaneously display an accurate range of multiple targets such as the flags of a golf practice driving range.

Abstract: The disclosed computer-implemented method may include dynamically selecting transportation options to present to a transportation requestor device based on current transportation network conditions and transportation requestor device history. In some embodiments, transportation network may have many different ways of arranging a transportation requestor's trip, such as private rides, shared rides, immediate rides, and delayed rides. In some examples, the requestor's choice of transportation option may have an impact on the transportation network. In anticipation of or in response to a transportation request, the method may determine which transportation options will better benefit the transportation network and determine which transportation options to display to the requestor and/or the prominence with which the transportation products are displayed. Various other methods, systems, and computer-readable media are also disclosed.

Abstract: Embodiments are directed to managing resources over a network. One or more resources that are unassigned. Selection models may be generated based on a one or more open appointments or one or more characteristics of one or more clients. The selection models may be employed to determine each client that is qualified to accept one or more invitations to the one or more open appointments. The one or more invitations to accept the one or more open appointments may be provided to the one or more qualified clients based on one or more notification models that define one or more communication modes to communicate the one or more invitations with the one or more candidate clients over a period of time. An open appointment may be reserved based on a qualified client accepting an invitation to the open appointment.

Abstract: A method is disclosed for severing a continuous reinforcement from a print head at conclusion of an event during fabrication of a composite structure. The method may include moving the print head a distance away from the composite structure that provides clearance for a cutting mechanism between an outlet of the print head and the composite structure, and responsively causing the cutting mechanism to make a first cut of the continuous reinforcement at a boundary of the composite structure. The method may also include moving the print head to a waste discard location, and responsively causing the cutting mechanism to make a second cut of the continuous reinforcement at a desired distance offset from the outlet of the print head.

Abstract: This disclosure describes a ceiling tile beamforming microphone array system that includes a plurality of microphones coupled together as a microphone array and used for beamforming processing, the plurality of microphones are positioned at predetermined locations that produce audio signals to be used to form a directional pickup pattern; one or more separate processing devices where one of the separate processing devices further includes beamforming processing; a single ceiling tile with an outer surface on the front side of the ceiling tile where the outer surface is acoustically transparent; where the ceiling tile beamforming microphone array system is used in a drop ceiling mounting configuration, where the microphone array couples to the back side of the ceiling tile and all or part of the ceiling tile beamforming microphone array system is in the drop space of the drop ceiling.

Abstract: An ionic liquid and a forward osmosis process employing the same are provided. The ionic liquid has a structure represented by Formula (I) ABn??Formula (I), wherein A is n is 1 or 2; m is 0, or an integer from 1 to 7; R1 and R2 are independently methyl or ethyl; k is an integer from 3 to 8; B is i is independently 1, 2, or 3; and j is 5, 6, or 7. The forward osmosis process employing the ionic liquid is used to desalinate a brine via a forward osmosis (FO) model.

Abstract: Techniques for exposing a subset of hosts on an overlay network, without exposing another subset of hosts on the overlay network, are disclosed. A component associated with an overlay network exposes a subset of hosts on the overlay network to components external to the overlay network. The component exposes the subset of hosts by distributing a mapping between (a) the hosts to-be-exposed and (b) the substrate addresses associated with the hosts. Alternatively, a component external to an overlay network exposes a subset of hosts on the overlay network to additional components external to the overlay network. The component exposes the subset of hosts by distributing a mapping between (a) the hosts to-be-exposed and (b) a substrate address associated with the particular component. In either embodiment, a mapping for hosts to-be-hidden is not distributed.

Abstract: An apparatus for making a composite article includes a monofilament feed track adapted to carry a spaced array of ceramic monofilament strands, a fiber yarn feed track adapted to carry a spaced array of fiber yarn tows impregnated with a plurality of glass particulates, a mandrel, and a heater assembly. The mandrel is adapted to wind together individual glass-impregnated fiber yarn strands and individual ceramic monofilament strands to form a dual-fiber weave. The heater assembly is adapted to heat at least the glass particulates such that pressure from the wound array of ceramic monofilaments is sufficient to consolidate the glass particulates and the dual-fiber weave into a dual-fiber ceramic matrix composite (CMC).