Abstract: A method for endo-phenotyping and risk stratifying obstructive sleep apnea (OSA) incudes acquiring signals associated with breathing over a period of time from a subject. In some embodiments, the signals associated with breathing are oxygen saturation signals (SpO2) that can be acquired using a SpO2 sensor. In some embodiments, the signals associated with breathing are snoring signals that can be acquired using an acoustic sensor. The method further includes determining at least one endo-phenotype of OSA using the acquired signals associated with breathing. In some embodiments, SpO2 signals can be used to determine endo-phenotypes including pharyngeal collapsibility, arousal threshold, ventilatory instability, hypoxic burden, and heart rate burden. In some embodiments, snoring signals can be used to determine endo-phenotypes including a site of airway collapse.

Abstract: A method for characterizing sleep disordered breathing may include identification of at least one of a plurality of predefined airway structural sources associated with a sleep disordered breathing event based on airflow data. In one example, an identification of at least one of a plurality of predefined airway structural sources associated with a sleep disordered breathing event is made based on data indicative of a ratio of a difference between a peak inspiratory airflow rate and a mid-inspiratory airflow rate to the peak inspiratory airflow rate captured during occurrence of the sleep disordered breathing event.

Abstract: A method for characterizing sleep disordered breathing may include identification of at least one of a plurality of predefined airway structural sources associated with a sleep disordered breathing event based on airflow data. In one example, an identification of at least one of a plurality of predefined airway structural sources associated with a sleep disordered breathing event is made based on data indicative of a ratio of a difference between a peak inspiratory airflow rate and a mid-inspiratory airflow rate to the peak inspiratory airflow rate captured during occurrence of the sleep disordered breathing event.