Abstract: An example hybrid power system includes a mobile platform comprising: a generator set comprising: a reciprocating engine configured to convert natural gas into rotational mechanical energy; and a generator configured to convert rotational mechanical energy sourced from the reciprocating engine into electrical energy; an electrical energy storage system (ESS) configured to store electrical energy; an electrical motor configured to convert electrical energy sourced from a combination of the generator set and the ESS into rotational mechanical energy; and a pump configured to operate using rotational mechanical energy sourced from the electrical motor.

Abstract: An electrified vehicle includes a chassis, a body coupled to the chassis, a battery enclosure supported by the chassis and defining an internal volume, a battery disposed within the internal volume, and a flood port accessible from an exterior of the electrified vehicle. The flood port is in direct or indirect fluid communication with the internal volume. The flood port is configured to receive a fluid from a fluid source and supply the fluid to the internal volume to cool the battery.

Abstract: A battery flooding system includes a flood port and an elongated connector. The flood port is configured to be fluidly coupled to a battery housing of an electrified vehicle. The elongated connector is configured to interface with the flood port to facilitate providing a fluid to the flood port from a fluid source such that the fluid is provided within the battery housing.

Abstract: An electrified fire fighting vehicle includes an energy storage system, a water tank configured to store water, a pump fluidly coupled to the water tank, a motor electrically coupled to the energy storage system and mechanically coupled to the pump, and a control system. The control system is configured to detect an onset of a thermal event in the energy storage system, control the motor to drive the pump such that the water can be recirculated out of and back into the water tank to facilitate draining a state of charge of the energy storage system, and provide a notification to electrically couple the energy storage system to an external load to facilitate draining the state of charge of the energy storage system.

Abstract: An electrified vehicle includes an energy storage system including a battery disposed within a battery housing and a control system. The control system is configured to detect an onset of a battery thermal event during a charging session of the energy storage system with an external power supply, in response to the onset of the battery thermal event being detected, perform a first action, and in response to the battery thermal event continuing to progress following the first action, perform a second action.

Abstract: An electrified vehicle includes a chassis, an energy storage system supported by the chassis, and a battery cooling system. The energy storage system includes a battery positioned within a battery housing. The battery cooling system includes a conduit positioned adjacent at least one of the battery or the battery housing and a fluid diverter positioned along the conduit. The fluid diverter is configured to facilitate selectively providing fluid communication between the conduit and the battery housing so that a fluid flowing through the conduit flows out of the conduit and at least one of into or around the battery housing.

Abstract: A vehicle includes an energy storage system, a battery cooling system, and a thermal event management system. The energy storage system includes a battery arranged within a battery housing. The battery cooling system includes a first conduit positioned internal to the battery housing and adjacent the battery. The first conduit is configured to facilitate circulating a first fluid through the battery housing to thermally regulate the battery. The thermal event management system includes a second conduit with a fluid diverter positioned therealong. The second conduit is positioned adjacent to at least one of the battery or the battery housing. The second conduit is configured to receive a second fluid. The fluid diverter is configured to facilitate selectively providing fluid communication between the second conduit and the battery housing so that the second fluid flows out of the second conduit and at least one of into or around the battery housing.

Abstract: A vehicle system includes a first vehicle, a second vehicle, and a control system. The first vehicle includes a first implement and a first actuator configured to facilitate controlling a first operation of the first implement. The second vehicle includes a second implement and a second actuator configured to control a second operation of the second implement. The control system is configured to receive an input from an operator, transmit a first signal to the first actuator based on the input to control the first operation of the first implement, and transmit a second signal to the second actuator based on the input to control the second operation of the second implement such that the first operation and the second operation are coordinated.

Abstract: Provided herein are compounds useful as inhibitors of Janus kinase (JAK) proteins and in treating JAK-related diseases.

Abstract: An electrified fire fighting vehicle includes a chassis, a cab coupled to the chassis, a body coupled to the chassis, a pump system, and a driveline. The driveline includes a front axle coupled to the chassis, a rear axle coupled to the chassis, an energy storage system, an engine coupled to the chassis, and an electromechanical device coupled to the chassis, the engine, and at least one of the front axle or the rear axle. The driveline is a dual drive driveline such that, during any and all modes of operation of the driveline, the electromechanical device is incapable of or prevented from charging the energy storage system at any time when driven by the engine.

Abstract: A vehicle includes a chassis, a driveline coupled to the chassis, and a control system. The control system is configured to monitor a condition of at least one of the vehicle, an area around the vehicle, or an operator of the vehicle; and control operation of the driveline based on the condition. Controlling the operation of the driveline includes at least one of limiting a speed at which the driveline drives the vehicle or shutting down the driveline and isolating a component of the driveline.

Abstract: An electrified fire fighting vehicle includes a chassis, a cab, a body assembly rearward of the cab, a front axle, a rear axle, an energy storage system, a pump system, an engine, a clutch coupled to the engine, an accessory drive coupled to the clutch, an electromechanical transmission electrically coupled to the energy storage system, and a thermal management system configured to thermally regulate the energy storage system and the electromechanical transmission. The pump system includes a pump configured to pump a fluid from a fluid source to a fluid outlet. The clutch is coupled to the engine. The electromechanical transmission includes a first interface coupled to the accessory drive, a second interface coupled to the pump, and a third interface coupled to at least one of the front axle or the rear axle. The electromechanical transmission is selectively driven by the engine through the clutch and the accessory drive.

Abstract: An electrified fire fighting vehicle includes a chassis, a cab coupled to the chassis, a body coupled to the chassis rearward of the cab, a front axle coupled to the chassis, a rear axle coupled to the chassis, an energy storage system coupled to the chassis and positioned rearward of the cab, a pump system positioned between the cab and the body, and an electromagnetic device. The electromagnetic device is electrically coupled to the energy storage system. The electromagnetic device is coupled to (i) the pump system and (ii) at least one of the front axle or the rear axle. The electromagnetic device is configured to receive electrical power from the energy storage system and provide a mechanical output to selectively drive (i) the pump system and (ii) the at least one of the front axle or the rear axle.

Abstract: A fire fighting vehicle includes a front axle, a rear axle, an energy storage system, an engine, a first motor/generator, and a second motor/generator. In a first mode, (a) the engine is off and (b) at least one of the first motor/generator or the second motor/generator uses stored energy in the energy storage system to drive at least one of the front axle or the rear axle. In a second mode, (a) the engine provides a mechanical input the first motor/generator, (b) the first motor/generator uses the mechanical input to generate electricity, (c) the second motor/generator uses the electricity to drive at least one of the front axle or the rear axle. Any electricity generated by either the first motor/generator or second motor/generator in response to the mechanical input from the engine is never provided to the energy storage system to charge the energy storage system.

Abstract: A fire apparatus includes a chassis, axles coupled to the chassis, a turntable rotatably coupled to the chassis, and an aerial ladder assembly pivotably coupled the turntable. The aerial ladder assembly includes a first ladder section extending longitudinally, a second ladder section extending longitudinally, and a support slidably coupling the second ladder section to the first ladder section such that the first ladder section supports the second ladder section. The support facilitates longitudinal movement of the second ladder section relative to the first ladder section between an extended position and a retracted position. The support is pivotably coupled to the first ladder section.

Abstract: Prostaglandin conjugates and derivatives and methods for their use to treat glaucoma and/or lower intraocular pressure are disclosed. Additionally, ophthalmic pharmaceutical compositions useful in the treatment of eye diseases such as glaucoma and elevated intraocular pressure are disclosed. Such compositions comprise an effective amount of prostaglandin conjugates or derivatives of the present invention.

Abstract: Prostaglandin conjugates and derivatives and methods for their use to treat glaucoma and/or lower intraocular pressure are disclosed. Additionally, ophthalmic pharmaceutical compositions useful in the treatment of eye diseases such as glaucoma and elevated intraocular pressure are disclosed. Such compositions comprise an effective amount of prostaglandin conjugates or derivatives of the present invention.

Abstract: Prostaglandin conjugates and derivatives and methods for their use to treat glaucoma and/or lower intraocular pressure are disclosed. Additionally, ophthalmic pharmaceutical compositions useful in the treatment of eye diseases such as glaucoma and elevated intraocular pressure are disclosed. Such compositions comprise an effective amount of prostaglandin conjugates or derivatives of the present invention.

Abstract: The invention provides compounds, pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of Cannabinoid Receptor 1 (CB1).

Abstract: The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of liver X receptors (LXRs).