Abstract: The present disclosure relates to medicament injection devices. An injection device includes: a movable dosage programming component comprising a rotary encoder system having a predefined angular periodicity, a sensor arrangement including a first optical sensor configured to detect movement of the movable dosage programming component relative to the sensor arrangement during dosing of a medicament, wherein the first optical sensor is configured to operate in a strobe-sampling mode at a first frequency, a second optical sensor configured to detect movement of the rotary encoder system relative to the second optical sensor wherein the second optical sensor is configured to operate in a strobe-sampling mode at a second frequency lower than the first frequency, and a processor arrangement configured to, based on the detected movement, determine a medicament dosage administered by the injection device.

Abstract: An electronic system for a drug delivery device is provided, the electronic system comprising at least one user interface member configured to be manipulated by a user for performing a dose operation, e.g.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, that identify and issue search queries expected to be issued in the future. A set of search queries that have been issued by multiple user devices can be obtained. For each query instance, contextual data can be obtained. A first query and its contextual data can be input to a model that outputs the query's likelihood of being issued in the future. The model can be trained using contextual data for training queries and a corresponding labels for the training queries. The learning model outputs the first query's likelihood of being issued in future, and this query is stored as a repeatable query if the likelihood satisfying a repeatability threshold. Subsequently, a stored repeatable query is issued upon a selection of a user selectable interface component and the search engine provides search results for the query.

Abstract: A computer-implemented method of constructing a customized information delivery system for a content owner to deliver information to recipients comprising constructing a directory of information assets for delivery to recipients. Profile characteristics and profile characteristic values for developing profiles of information recipients are determined, as are a set of content themes. The information assets are associated with the content themes. For at least some of the information assets, a delivery priority or a relevance to a profile characteristic value, or both, are provided. Actions for determining profile characteristic values from a recipient are determined, whereby an action may be presented to a recipient on delivery of an information asset to the recipient. An action may be provided to the recipient to determine profile characteristic values of the recipient—the responses can be used to form a modified profile for providing further information assets to the recipient.

Abstract: Methods of testing tumor samples for mutational burden and/or for expression profiles permit the prediction of responsiveness of an individual to immunotherapy comprising PVSRIPO. Those predicted to respond are treated with PVSRIPO and those predicted not to respond are treated with other agents.

Abstract: A surround view system for a vehicle includes: a three-dimensional geometry unit configured to receive vehicle surrounding environment data and generate a three-dimensional model of a vehicle surrounding environment based on the received vehicle surrounding environment data; and a view generation unit configured to receive visual data and map the visual data to portions of the three-dimensional model based on the spatial and/or temporal information of the visual data and the vehicle surrounding environment data to form a virtual surround view.

Abstract: Methods of testing tumor samples for mutational burden and/or for expression profiles permit the prediction of responsiveness of an individual to immunotherapy comprising PVSRIPO. Those predicted to respond are treated with PVSRIPO and those predicted not to respond are treated with other agents.

Abstract: A surround view system for a vehicle includes: a three-dimensional geometry unit configured to receive vehicle surrounding environment data and generate a three-dimensional model of a vehicle surrounding environment based on the received vehicle surrounding environment data; and a view generation unit configured to receive visual data and map the visual data to portions of the three-dimensional model based on the spatial and/or temporal information of the visual data and the vehicle surrounding environment data to form a virtual surround view.

Abstract: A meibomian gland manual device allows for a cost-effective device for use in the home by individuals who suffer from dry eye or for daily eye hygiene. The device allows for a safe self-administration to gently express the meibomian gland, the leading underlying cause of chronic dry eye. The semi-circular projection and an affixed moist heated pad, combined with the action of gently applying pressure to the eyelid while following the natural direction of the eyelid, increases the effectiveness of expressing the meibomian gland. The material of the device allows for ease of cleaning for repeated use. Combining the device with either a warm shower or applying a warm compress to the eyes increases the effectiveness of the device to induce a manual extraction of the gland contents.

Abstract: A meibomian gland manual device allows for a cost-effective device for use in the home by individuals who suffer from dry eye or for daily eye hygiene. The device allows for a safe self-administration to gently express the meibomian gland, the leading underlying cause of chronic dry eye. The semi-circular projection combined with the action of gently applying pressure to the eyelid while following the natural direction of the eyelid, increases the effectiveness of expressing the meibomian gland. The material of the device allows for ease of cleaning for repeated use. Combining the device with either a warm shower or applying a warm compress to the eyes increases the effectiveness of the device to induce a manual extraction of the gland contents.

Abstract: Human sebum mimetics and methods for producing human sebum mimetics are provided. In one exemplary embodiment, a human sebum mimetic comprises a wax ester derived from interesterification of a refined botanical triglyceride oil comprising palmitoleic acid and refined jojoba oil, a phytosterol, phytosqualene, and phytosteryl macadamiate. A method for producing a human sebum mimetic comprises mixing refined macadamia oil and refined jojoba oil, interesterifying the macadamia oil and the jojoba oil, adding a phytosterol, adding phytosteryl macadamiate, and adding phytosqualene after interesterification.

Abstract: The invention (10), Retractable Vertical Mount Bicycle Storage Rack, is a manufactured mechanical assembly that serves as a stationary bicycle storage device, where a bicycle is conveniently stored in a vertical configuration. The invention is a mechanical mechanism that extends outward away from its mounting surface (example=wall, post, etc.) creating an articulating cradle-like assembly for allowing a bicycle to be stored vertically, and may be retracted towards its mounting surface when not in use. The invention utilizes mechanical geometry to maintain its position in both positions, extended and retracted. The bicycle maintains its position with gravity and only contacts the invention with its front tire, thus protecting any delicate bicycle components from physical contact with the storage rack.

Abstract: The present disclosure provides a dual-action pest control formulation for controlling rodents and arthropods, the formulation including: a rodenticide; an insecticide; an optional attractant; and a carrier matrix. The present disclosure also provides a method of controlling rodents and arthropods, the method including: applying the dual action pest formulation to a target area.

Abstract: Human sebum mimetics and methods for producing human sebum mimetics are provided. In one exemplary embodiment, a human sebum mimetic comprises a wax ester derived from interesterification of refined botanical oil comprising palmitoleic acid and refined jojoba oil, a phytosterol, and phytosqualene. A method for producing a human sebum mimetic comprises mixing refined macadamia oil and refined jojoba oil, interesterifying the refined macadamia oil and the refined jojoba oil, adding a phytosterol alter the interesterifying, and adding phytosqualene after the interesterifying.

Abstract: Human sebum mimetics and methods for producing human sebum mimetics are provided. In one exemplary embodiment, a human sebum mimetic comprises a wax ester derived from interesterification of refined botanical oil comprising palmitoleic acid and refined jojoba oil, a phytosterol, phytosqualene, and/or phytosteryl macadamiate. Method for producing a human sebum mimetic comprises mixing refined macadamia oil and refined jojoba oil, interesterifying the refined macadamia oil and the refined jojoba oil, adding a phytosterol, adding phytosteryl macadamiate, and adding phytosqualene after the interesterifying.

Abstract: Human sebum mimetics and methods for producing human sebum mimetics are provided. In one exemplary embodiment, a human sebum mimetic comprises a wax ester derived from interesterification of a refined botanical triglyceride oil comprising palmitoleic acid and refined jojoba oil, a phytosterol, phytosqualene, and phytosteryl macadamiate. A method for producing a human sebum mimetic comprises mixing refined macadamia oil and refined jojoba oil, interesterifying the macadamia oil and the jojoba oil, adding a phytosterol, adding phytosteryl macadamiate, and adding phytosqualene after interesterification.

Abstract: The invention (10), Retractable Vertical Mount Bicycle Storage Rack, is a manufactured mechanical assembly that serves as a stationary bicycle storage device, where a bicycle is conveniently stored in a vertical configuration. The invention is a mechanical mechanism that extends outward away from its mounting surface (example=wall, post, etc.) creating an articulating cradle-like assembly for allowing a bicycle to be stored vertically, and may be retracted towards its mounting surface when not in use. The invention utilizes mechanical geometry to maintain its position in both positions, extended and retracted. The bicycle maintains its position with gravity and only contacts the invention with its front tire, thus protecting any delicate bicycle components from physical contact with the storage rack.

Abstract: Human sebum mimetics and methods for producing human sebum mimetics are provided. In one exemplary embodiment, a human sebum mimetic comprises a wax ester derived from interesterification refined botanical oil comprising palmitoleic acid and refined jojoba oil, a phytosterol, and phytosqualene. A method for producing a human sebum mimetic comprises mixing refined macadamia oil and refined jojoba oil, interesterifying the refined macadamia oil and the refined jojoba oil, adding a phytosterol after the interesterifying, and adding phytosqualene after the interesterifying.