Abstract: A computing platform is adapted to deliver customized information to recipients. A directory of information assets is provided in which information assets are identified and made available for delivery to recipients. A profiling module delivers profile characteristics and associated profile characteristic values for recipients for the information assets and a theme building module for determination of a set of content themes, wherein the theme building module is adapted to associate the information assets in the directory with the content themes. A sequencing module is adapted to provide for at least some of the information assets, a delivery priority or a relevance to a profile characteristic value, or both. An action configuration module is adapted to provide determination of a plurality of actions for determining profile characteristic values from a recipient, whereby an action may be presented to a recipient on delivery of an information asset to the recipient.

Abstract: The present disclosure describes methylation markers in the STING promoter useful for making treatment decisions regarding certain cancer and tumors, such as cranial cancers or extracranial cancers of neuroectodermal embryologic origin. The present disclosure also describes methylation markers in the STING promoter for making treatment decisions regarding brain malignancies. These methylation markers serve as indicators of the likelihood of the tumor or cancer being responsive to certain therapeutic modalities, such as an immunotherapy. The present disclosure also describes methods of decreasing the methylation state of the STING promoter in a patient via the administration of a demethylating agent to improve outcomes and increase the likelihood of responding positively to therapies.

Abstract: The present disclosure provides a method of measuring the production of a cytokine in a sample in response to an agonist to determine responsiveness of a patient to immunotherapy. The present disclosure also provides a method of treating a cancer patient with an oncolytic viral therapy when a sample from the patient has a certain level of anti-viral antibodies. Further, the present disclosure describes, in part, an immune competence blood test that allows for one skilled in the art to determine if a tumor is immunoproficient to respond to an immunotherapy.

Abstract: A computer-implemented method of constructing a customized information delivery system for a content owner to deliver information to recipients comprising constructing a directory of information assets for delivery to recipients. Profile characteristics and profile characteristic values for developing profiles of information recipients are determined, as are a set of content themes. The information assets are associated with the content themes. For at least some of the information assets, a delivery priority or a relevance to a profile characteristic value, or both, are provided. Actions for determining profile characteristic values from a recipient are determined, whereby an action may be presented to a recipient on delivery of an information asset to the recipient. An action may be provided to the recipient to determine profile characteristic values of the recipient—the responses can be used to form a modified profile for providing further information assets to the recipient.

Abstract: Methods of testing tumor samples for mutational burden and/or for expression profiles permit the prediction of responsiveness of an individual to immunotherapy comprising PVSRIPO. Those predicted to respond are treated with PVSRIPO and those predicted not to respond are treated with other agents.

Abstract: Methods of testing tumor samples for mutational burden and/or for expression profiles permit the prediction of responsiveness of an individual to immunotherapy comprising PVSRIPO. Those predicted to respond are treated with PVSRIPO and those predicted not to respond are treated with other agents.

Abstract: Human sebum mimetics and methods for producing human sebum mimetics are provided. In one exemplary embodiment, a human sebum mimetic comprises a wax ester derived from interesterification of refined botanical oil comprising palmitoleic acid and refined jojoba oil, a phytosterol, and phytosqualene. A method for producing a human sebum mimetic comprises mixing refined macadamia oil and refined jojoba oil, interesterifying the refined macadamia oil and the refined jojoba oil, adding a phytosterol alter the interesterifying, and adding phytosqualene after the interesterifying.

Abstract: Human sebum mimetics and methods for producing human sebum mimetics are provided. In one exemplary embodiment, a human sebum mimetic comprises a wax ester derived from interesterification of refined botanical oil comprising palmitoleic acid and refined jojoba oil, a phytosterol, phytosqualene, and/or phytosteryl macadamiate. Method for producing a human sebum mimetic comprises mixing refined macadamia oil and refined jojoba oil, interesterifying the refined macadamia oil and the refined jojoba oil, adding a phytosterol, adding phytosteryl macadamiate, and adding phytosqualene after the interesterifying.

Abstract: The disclosed composition and method includes the use of non-polar unsaponifiable material and polar hydrophilic salts in conjunction with quaternary ammonium compounds to provide hair treatment preparations for cosmetic and personal care applications. Disclosed features and specifications may be variously controlled, adapted or otherwise optionally modified to improve substantivity and/or rinse-off characteristics. Exemplary embodiments of the present invention generally provide hair conditioners, shampoos, straighteners, permanent waves, color-fast dyes, non-color-fast dyes, and repair treatments with jojoba hydrolysates in combination with Quaternium 80 for increased substantivity and superior wash/rinse-off benefits.

Abstract: The disclosed composition and method includes the use of non-polar unsaponifiable material and polar hydrophilic salts in conjunction with quaternary ammonium compounds to provide hair treatment preparations for cosmetic and personal care applications. Disclosed features and specifications may be variously controlled, adapted or otherwise optionally modified to improve substantivity and/or rinse-off characteristics. Exemplary embodiments of the present invention generally provide hair conditioners, shampoos, straighteners, permanent waves, color-fast dyes, non-color-fast dyes, and repair treatments with jojoba hydrolysates in combination with Quaternium 80 for increased substantivity and superior wash/rinse-off benefits.

Abstract: The disclosed composition and method includes the use of non-polar unsaponifiable material and polar hydrophilic salts in conjunction with quaternary ammonium compounds to provide hair treatment preparations for cosmetic and personal care applications. Disclosed features and specifications may be variously controlled, adapted or otherwise optionally modified to improve substantivity and/or rinse-off characteristics. Exemplary embodiments of the present invention generally provide hair conditioners, shampoos, straighteners, permanent waves, color-fast dyes, non-color-fast dyes, and repair treatments with jojoba hydrolysates in combination with Quaternium 80 for increased substantivity and superior wash/rinse-off benefits.

Abstract: Botanically-sourced and botanically-derived emollient sanitation compositions for topical use are disclosed. Representative compositions generally aid reconstitution of the lipid profile of the stratum corneum by providing botanical lipids and/or lipid-derivatives that resemble human sebum—these components being ordinarily diminished with the use of conventional hand sanitizer products. Disclosed features and specifications may be variously controlled, adapted or optionally modified to realize, for example, improved hand sanitizer formulations. Representative embodiments of the present invention generally provide anti-microbial compositions blended with botanically sourced lipids and/or lipid-derivatives to control or otherwise improve dermatitic symptoms associated with frequent use of conventional hand sanitizer products.

Abstract: This invention relates to a method, a system and a computer program product for generating custom databases. It is emphasized that this abstract is provided to comply with the rules requiring an abstract that will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure; and is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims under 37 CFR 1.72.

Abstract: This invention relates to a method, a system and a computer program product for generating custom databases. It is emphasized that this abstract is provided to comply with the rules requiring an abstract that will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure; and is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims under 37 CFR 1.72.