Abstract: Disclosed herein are novel methodologies of treating fragile X syndrome and related disorders by inhibiting mGlu5-relevant signaling pathways via the reduction of ?-arrestin2 protein levels or the diminution of mGlu5 and ?-arrestin2 protein interactions.

Abstract: Disclosed herein are novel methodologies of treating fragile X syndrome and related disorders by inhibiting mG1u5-relevant signaling pathways via the reduction of ?-arrestin2 protein levels or the diminution of mG1u5 and ?-arrestin2 protein interactions.

Abstract: Subjects having elevated signaling of a mammalian target of rapamycin (mTOR) are treated with compositions that include at least one compound that activates a Group 1 mGluR. In an embodiment, the subject has tuberous sclerosis complex (TSC). In an embodiment, the compound is a Group 1 mGluR agonist. In another embodiment, the compound is a Group 1 mGluR positive allosteric modulator.

Abstract: A unitary flexible body having an anchor portion wrapping about the wrist to secure the body there, the anchor portion freely offset from the thumb, palm and dorsum of the hand, the body having a support extension extending distally from the anchor portion in supporting relation with the Thenar Emminence of the palm, and extending part way about the thumb via the web space between the thumb and forefinger, and having terminal attachment to said anchor portion.

Abstract: In a thumb wrap, the combination comprising a user's hand and wrist flexible wrap, a generally tubular portion to receive the user's thumb, said tubular portion being integral with the hand and wrap, a securing strap endwise seamlessly integral with the hand and wrist wrap, and extending with elongation to be wrapped over the hand and wrist wrap palmwise and endwise of the tubular portion and then to be wrapped between the user's thumb and forefinger, and then back over the hand and wrist wrap for tensioned tightening and for the effecting thumb positively supported securement.

Abstract: A unitary flexible body having an anchor portion wrapping about the wrist to secure the body there, the anchor portion freely offset from the thumb, palm and dorsum of the hand, the body having a support extension extending distally from the anchor portion in supporting relation with the Thenar Emminence of the palm, and extending part way about the thumb via the web space between the thumb and forefinger, and having terminal attachment to said anchor portion.

Abstract: A generic backhaul protocol is provided for passing telecommunication signaling messages according to multiple signaling protocols between a gateway and a media gateway controller. A message in accordance with the generic backhaul protocol includes a message header that indicates the signaling protocol and/or the channel being used on the gateway. The message also includes a message body that contains a protocol data unit encapsulating signaling data in accordance with a signaling protocol.

Abstract: Systems and methods for generating a user interface are described. In one described system, an aspect associated with an article is identified. Next, an insert comprising a search result is generated based, at least in part, on the aspect. The insert is then caused to be output in association with the aspect.

Abstract: An apparatus including a compartment to store a medicament, a communication facility to exchange data with a health information provider, a display system to present information to a user, and a timekeeping subsystem to activate the display at a predetermined time is described and claimed. Methods of using similar devices, and computer software to control such devices, are also described and claimed.

Abstract: Communicating voice over a packet-switching network is implemented on a telecommunications network that includes the packet-switching network, two coding units coupled to the packet-switching network and to an originating node and a terminating node, respectively, and at least one signaling apparatus. The first of the two coding units is configured to extract signaling data associated with the voice call and transmit the signaling data and its network address to the signaling apparatus. Signaling data for establishing the voice call is received by the signaling apparatus, and a network address of the coding unit in the packet-switching network is obtained. The second coding unit is controlled to establish a bearer channel with the first coding unit for carrying the voice data through the packet-switching network, based on the network address.

Abstract: A mobile router is configured for optimized utilization of reverse routing headers, to specify a path between an originating mobile router and a home agent. Reverse routing headers enable each mobile router within the path to the home agent to specify its care of address, enabling the home agent to establish a bidirectional tunnel to the originating mobile router via the corresponding mobile router. The mobile router selectively updates the reverse routing header in a received packet by inserting the source address value of the received packet into the reverse routing header and inserting its corresponding care of address into the source address field, based on whether the mobile router lacks a routing table entry that specifies reachability of a most recent entry in the reverse routing header via the source address value. The mobile router also may request the originating mobile router to increase the reverse routing header size.

Abstract: A schema-based service for Internet access to per-user services data, wherein access to data is based on each user's identity. The service includes a schema that defines rules and a structure for each user's data, and also includes methods that provide access to the data in a defined way. The services schema thus corresponds to a logical document containing the data for each user. The user manipulates (e.g., reads or writes) data in the logical document by data access requests through defined methods. In one implementation, the services schemas are arranged as XML documents, and the services provide methods that control access to the data based on the requesting user's identification, defined role and scope for that role. In this way, data can be accessed by its owner, and shared to an extent determined by the owner.

Abstract: An arm brace comprising an elongated relatively stiff support configured for application adjacent the inner side of the arm and for nesting adjacent the obtusely angled inner side zone of the partly bent arm opposite the elbow; retainer straps carried by the support near opposite ends thereof, to be independently tightened about the arm at retention locations spaced from a shallow angle shaped mid-section of the support, whereby the user's arm is maintained in shallowly bent condition by the brace.

Abstract: An apparatus and method for storing a medicament and alerting a patient when to take the medicament. The apparatus contains a processor, which is programmed to indicate when the patient is scheduled to take a medicament, and which medicament is to be taken. At the scheduled time, the patient is alerted and at least one characteristic (i.e. size, shape, color, etc.) of the medicament scheduled to be taken is described to the patient. The patient is also able to view previously scheduled medicaments as well as a schedule of medicaments to be taken in the future.

Abstract: Systems and methods for processing media files are described. In one embodiment, one or more events are captured having associated event data and associated with a client device, wherein each event is associated with an article and at least one of the articles is a media file, wherein at least one of the events is captured in real time upon the occurrence of the event, at least some of the event data and articles associated with the events are indexed and stored, a search query is received, and the at least one media file is determined as relevant to the search query.

Abstract: Systems and methods for processing email messages are described. In one embodiment, the occurrence of a condition is determined indicating at least one email message transfer of an email message by an email application, wherein determining the occurrence of the condition is external to the email application, the email message is identified, wherein the email message comprises event data, an email event is compiled from at least some of the event data, and the email event is indexed.