Abstract: A protective impact device is provided that produces an approximately constant force during compression. The device distinguishes several structural features. First, the cross-sectional area in between two impact surfaces increases over the stroke distance when compression takes place. Second, a compressible fluid containing vessel, held in between two impact surfaces, defines an outer shape with a positive second derivative slope defined from one impact surface towards the other impact surface. Third, orifices allow the fluid to bleed out from the compressible vessel when an impact force causes compression of the protective impact device. The resulting approximately constant force scales more or less linearly with impact energy, regardless of impact velocity caused by the impact force. Applications include athletic equipment, automotive bumpers, aircraft landing gear, and any other application that would benefit from maximum energy absorption during an impact.

Abstract: A ventilator system configured to switch between one or more invasive ventilation modes and one or more non-invasive ventilation modes is provided, the ventilator system comprising: an externally pressurized source of pre-mixed gas comprising air and oxygen; one or more inspiratory valves configured to deliver incoming pre-mixed gas to a patients breathing circuit; and one or more expiratory valves configured to remove outgoing gas from the patients breathing circuit; wherein in the one or more invasive ventilation modes, the inspiratory valves and the expiratory valves are configured to open and close to allow or prevent the passage of gas as needed in order to enforce a respiration cycle within the patient; and wherein in the one or more non-invasive ventilation modes, the inspiratory valves and the expiratory valves are kept open in order to allow the gas to pass freely through the system.

Abstract: An oral appliance includes: 1) a body defining a channel to accommodate an upper dentition; and 2) a motion sensor. The body includes a front portion defining a recess, and the motion sensor is affixed to the front portion.

Abstract: Devices, systems, and methods for shock absorption are provided herein. Collapsible shock absorption devices have an inner wall having at least one orifice, an outer wall, and a fluid sealed within the outer wall can mitigate sharp increases in force during loading and can better distribute loading forces. In some cases, collapsible shock absorption devices disclosed herein are used for prevention of injury to a biological tissue of a subject or damage to an inanimate object.

Abstract: Systems, methods and devices for detecting a concussive event are provided. A computational classifier may be trained and utilized for detecting a concussive event in real-time. Head kinematics can be measured and a head kinematic metric determined, which can be utilized within the classifier to detect a concussive event.

Abstract: Certain aspects relate to systems and techniques for localizing and/or navigating a medical instrument within a luminal network. A medical system can include an elongate body configured to be inserted into the luminal network, as well as an imaging device positioned on a distal portion of the elongate body. The system may include memory and processors configured to receive from the imaging device image data that includes an image captured when the elongate body is within the luminal network. The image can depict one or more branchings of the luminal network. The processor can be configured to access a machine learning model of one or more luminal networks and determine, based on the machine learning model and information regarding the one or more branchings, a location of the distal portion of the elongate body within the luminal network.

Abstract: Autonomous closed loop control of a flexible tendon-driven continuum manipulator having a sensor at a distal tip is performed by measuring spatial attributes of a sensor at the distal tip and estimating an orientation of a base of an articulating region of the flexible tendon-driven continuum manipulator from a kinematic model and the spatial attributes of the sensor. The manipulator control in a task space uses the estimated orientation, a desired trajectory in the task space, and the position of the sensor at the distal tip. The sensor at the distal tip may be a magnetic sensor, impedance sensor, or optical sensor.

Abstract: A protective impact device is provided that produces an approximately constant force during compression. The device distinguishes several structural features. First, the cross-sectional area in between two impact surfaces increases over the stroke distance when compression takes place. Second, a compressible fluid containing vessel, held in between two impact surfaces, defines an outer shape with a positive second derivative slope defined from one impact surface towards the other impact surface. Third, orifices allow the fluid to bleed out from the compressible vessel when an impact force causes compression of the protective impact device. The resulting approximately constant force scales more or less linearly with impact energy, regardless of impact velocity caused by the impact force. Applications include athletic equipment, automotive bumpers, aircraft landing gear, and any other application that would benefit from maximum energy absorption during an impact.

Abstract: A method includes receiving position information and force information, providing control commands to a steering mechanism of a continuum manipulator based on the position information and the force information, updating a control matrix based on the position information and the provided control commands, and providing updated control commands to the steering mechanism based on the updated control matrix. A continuum manipulator includes a body, a steering mechanism configured to steer the body, sensors, and a controller. The sensors include a position sensor to detect a position of the body and a force sensor to detect a force against the body. The controller is configured to receive position information from the position sensor and force information from the force sensor, provide control commands to the steering mechanism based on the position information and the force information, and update a control matrix based on the position information and the provided control commands.

Abstract: Provided is a device for placement on a human subject to detect impacts on the human subject. The device includes a base member, one or more engagement sensors to detect whether the device is properly placed on the human subject, and one or more motion sensors to detect the kinematics of the human subject. The device also includes a processing unit that includes methodology to detect false positives such as chewing, dropping, and throwing.

Abstract: Provided are methods for the determination of the viability of a mammalian embryo or a potential embryo generated from a mammalian oocyte, comprising applying a mechanical stimulus to the embryo or oocyte, detecting a temporal response of the embryo or oocyte to the mechanical stimulus, and deriving measurements for one or more parameters from the temporal response, the measurements being indicative of viability. Also provided are methods for selecting an embryo for transfer and methods for enhancing the viability of an embryo or oocyte.

Abstract: Autonomous closed loop control of a flexible tendon-driven continuum manipulator having a sensor at a distal tip is performed by measuring spatial attributes of a sensor at the distal tip and estimating an orientation of a base of an articulating region of the flexible tendon-driven continuum manipulator from a kinematic model and the spatial attributes of the sensor. The manipulator control in a task space uses the estimated orientation, a desired trajectory in the task space, and the position of the sensor at the distal tip. The sensor at the distal tip may be a magnetic sensor, impedance sensor, or optical sensor.

Abstract: A method includes receiving position information and force information, providing control commands to a steering mechanism of a continuum manipulator based on the position information and the force information, updating a control matrix based on the position information and the provided control commands, and providing updated control commands to the steering mechanism based on the updated control matrix. A continuum manipulator includes a body, a steering mechanism configured to steer the body, sensors, and a controller. The sensors include a position sensor to detect a position of the body and a force sensor to detect a force against the body. The controller is configured to receive position information from the position sensor and force information from the force sensor, provide control commands to the steering mechanism based on the position information and the force information, and update a control matrix based on the position information and the provided control commands.

Abstract: An oral appliance includes: 1) a body defining a channel to accommodate an upper dentition; and 2) a motion sensor. The body includes a front portion defining a recess, and the motion sensor is affixed to the front portion.

Abstract: A control method includes empirically constructing for a flexible manipulator an estimated mapping between an end-effector movement and a plurality of values representing movement of at least one actuator, measuring an actual end-effector movement and an actual movement of the at least one actuator, and, based on the measuring, updating the estimated mapping while the flexible manipulator is active such that the mapping is adapted to the present environment of the flexible manipulator.

Abstract: Provided are methods for the determination of the viability of a mammalian embryo or a potential embryo generated from a mammalian oocyte, comprising applying a mechanical stimulus to the embryo or oocyte, detecting a temporal response of the embryo or oocyte to the mechanical stimulus, and deriving measurements for one or more parameters from the temporal response, the measurements being indicative of viability. Also provided are methods for selecting an embryo for transfer and methods for enhancing the viability of an embryo or oocyte.

Abstract: Provided are methods for the determination of the viability of a mammalian embryo or a potential embryo generated from a mammalian oocyte, comprising applying a mechanical stimulus to the embryo or oocyte, detecting a temporal response of the embryo or oocyte to the mechanical stimulus, and deriving measurements for one or more parameters from the temporal response, the measurements being indicative of viability. Also provided are methods for selecting an embryo for transfer and methods for enhancing the viability of an embryo or oocyte.

Abstract: Robotic instrument systems and control implementations are disclosed. In one such system, an elongate guide instrument such as a guide catheter includes tension or deflection element such as a stainless steel wire or pull wire. An actuator, such as a servo motor, is operably coupled to the controller. The controller is configured to control actuation of the servo motor based on execution of a control model including a mechanics model that accounts for a force on the guide instrument. The control model may also utilize both kinematics and mechanics models. The controller is configured to control actuation of the actuator based the control model that includes the mechanics model such that the elongate guide instrument bends when the actuator moves the deflection member.

Abstract: Described herein is a system for redirecting head impact force to other portion or portions of a body of a person. The system includes a harness wearable on upper body or both upper and lower body of the person and permitting motion of the person; a force redirecting element configured to connect the harness to a helmet wearable by the person; and a motion limiting unit connected to the force redirecting element, wherein the motion limiting unit can be triggered by the impact and limit the load on the neck of the person. The system also includes stiffening units to pre-tension the harness and increase the effective impedance of the system.

Abstract: Described herein is a wearable device for redirecting head impact force from the head of a person to other body part or parts of the person, the device comprising: a helmet wearable on the head of the person; a brace wearable on the body of the person; and at least one force redirecting unit configured for connection to the helmet and the brace, wherein at least one of the force redirecting unit is configured to be compressed to carry compressive load, and at least one of the force redirecting unit is configured to be extended to carry tensile load.