Patents by Inventor David B. Finkelstein

David B. Finkelstein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Gene encoding one step cephalosporin C amidase and expression thereof in recombinant bacillus
    Patent number: 5229274
    Abstract: A process for the one-step conversion of cephalosporin C and derivatives thereof to the corresponding 7-aminocephalosporanic acid and derivatives comprising treating said cephalosporin C and derivatives with a cephalosporin C amidase enzyme of a recited sequence, the DNA encoding said enzyme, and expression thereof in a suitable host, e.g., Bacillus species under the control of a suitable promoter.
    Type: Grant
    Filed: January 13, 1992
    Date of Patent: July 20, 1993
    Assignee: Merck & Co., Inc.
    Inventors: Mark S. Crawford, David B. Finkelstein, John A. Rambosek
  • One-step cephalosporin C amidase enzyme
    Patent number: 5104800
    Abstract: A process for the one-step conversion of cephalosporin C and derivatives thereof to the corresponding 7-aminocephalosporanic acid and derivatives comprising treating said cephalosporin C and derivatives with a cephalosporin C amidase enzyme of a recited sequence, the DNA encoding said enzyme, and expression thereof in a suitable host, e.g., Bacillus species under the control of a suitable promoter.
    Type: Grant
    Filed: June 27, 1989
    Date of Patent: April 14, 1992
    Assignee: Merck & Co., Inc.
    Inventors: Mark S. Crawford, David B. Finkelstein, John A. Rambosek
  • Heat shock regulated production of selected and fused proteins in yeast
    Patent number: 4797359
    Abstract: A process for producing a yeast capable of heat regulated synthesis of selected and fused proteins is disclosed. The process involves the combination of a DNA fragment comprising a heat shock inducible gene of an appropriate yeast microorganism and a second DNA fragment comprising a selected gene with a suitable transfer vector, thereby producing a recombinant transfer vector. A suitable host yeast is contacted with the recombinant transfer vector, cultured and transforments having the desired genetic capability are selected.
    Type: Grant
    Filed: May 10, 1983
    Date of Patent: January 10, 1989
    Assignee: Board of Regents, The University of Texas System
    Inventor: David B. Finkelstein