Patents by Inventor David B. Joseph

David B. Joseph has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Crystalline forms of (3S-trans)-2-[3,4-dihydro-4-hydroxy-3-(phenylmethyl)-2H-1-benzopyran-7-yl]-4-(trifluoromethyl)-benzoic acid
    Patent number: 6436987
    Abstract: The present invention provides novel polymorphic forms of anhydrous crystalline (3S-trans)-2-[3,4-dihydro-4-hydroxy-3-(phenylmethyl)-2H-1-benzopyran-7-yl]-4-(trifluoromethyl)-benzoic acid, hereinafter compound (I), and a novel salt, and a hydrate of said compound, wherein each novel composition has particular characteristics that contribute to its use in pharmaceutical formulations. The novel monohydrate of compound (I) is described, which can be advantageously isolated from water wet solvents and formulated via wet granulation techniques. The novel ethylene diamine (mono) salt is also described, and demonstrates superior solubility and bioavailability. Additionally, polymorphic forms A and B of anhydrous crystalline compound (I) are described, wherein form A has superior thermal stability, and form B has superior solubility.
    Type: Grant
    Filed: March 13, 2001
    Date of Patent: August 20, 2002
    Assignee: Pfizer Inc.
    Inventors: Douglas J. M. Allen, Nancy A. Sage, David B. Joseph
  • Novel crystalline forms of (3S-trans)-2-[3,4-dihydro-4-hydroxy-3-(phenylmethyl)-2H-1-benzopyran-7-yl]-4-(trifluoromethyl)-benzoic acid
    Publication number: 20020035144
    Abstract: The present invention provides novel polymorphic forms of anhydrous crystalline (3S-trans)-2-[3,4-dihydro-4-hydroxy-3-(phenylmethyl)-2H-1-benzopyran-7-yl]-4-(trifluoromethyl)-benzoic acid, hereinafter compound (I), and a novel salt, and a hydrate of said compound, 1
    Type: Application
    Filed: March 13, 2001
    Publication date: March 21, 2002
    Inventors: Douglas J.M. Allen, Nancy A. Sage, David B. Joseph
  • Zwitterionic forms of trovafloxacin
    Patent number: 6066647
    Abstract: The invention relates to a non-hygroscopic polymorph of the following compound ##STR1## and to pharmaceutical compositions containing the above compound, methods of treating bacterial infections by administering the above compound, and to methods of preparing the above compound and related compounds.
    Type: Grant
    Filed: January 29, 1998
    Date of Patent: May 23, 2000
    Assignee: Pfizer Inc.
    Inventors: Allen J. M. Douglas, David B. Joseph, Timothy Norris