Patents by Inventor David B. Pearse

David B. Pearse has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of an NADPH-oxidase inhibitor in the treatment of reperfusion injury
    Patent number: 6090851
    Abstract: The present invention is directed to a method for the prophylactic and therapeutic treatment of reperfusion injury or injury due to a distal reperfusion. The method involves the administration of an NADPH-oxidase inhibitor to a cell, tissue, organ or animal in an amount sufficient to treat the cell, tissue, organ or animal for reperfusion injury prophylactically or therapeutically. The NADPH-oxidase inhibitor preferably is an o-methoxycatechol, or a pharmaceutically acceptable salt, derivative, dimer or prodrug thereof. Most preferably, the o-methoxycatechol is apocynin.
    Type: Grant
    Filed: September 9, 1998
    Date of Patent: July 18, 2000
    Assignee: Johns Hopkins University School of Medicine
    Inventors: Jeffrey M. Dodd-o, David B. Pearse