Patents by Inventor David B. Rhoads

David B. Rhoads has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Enhanced engineered native promoters and uses thereof
    Patent number: 8829177
    Abstract: We describe methods and DNA constructs/engineered mammalian promoters to enhance native promoter activity while retaining inherent regulation by inserting multi-copy response elements (REs) into non-adjacent locations. Multiple copies of REs are clustered in a group forming a transcription factor response element segment. The segment is at least duplicated in tandem upstream of the ATG start codon. Spacers of 0.2-0.7 kilo base pairs are introduced between the two segments and smaller spacers of about between 9-15 bp are introduced between the copies of REs within a segment.
    Type: Grant
    Filed: June 5, 2010
    Date of Patent: September 9, 2014
    Assignee: The General Hospital Corporation
    Inventors: David B. Rhoads, Jianmin Huang, Lynne L. Levitsky
  • ENHANCED ENGINEERED NATIVE PROMOTERS AND USES THEREOF
    Publication number: 20120094375
    Abstract: We describe methods and DNA constructs/engineered mammalian promoters to enhance native promoter activity while retaining inherent regulation by inserting multi-copy response elements (REs) into non-adjacent locations. Multiple copies of REs are clustered in a group forming a transcription factor response element segment. The segment is at least duplicated in tandem upstream of the ATG start codon. Spacers of 0.2-0.7 kilo base pairs are introduced between the two segments and smaller spacers of about between 9-15 by are introduced between the copies of REs within a segment.
    Type: Application
    Filed: June 5, 2010
    Publication date: April 19, 2012
    Applicant: THE GENERAL HOSPITAL CORPORATION
    Inventors: David B. Rhoads, Jianmin Huang, Lynne L. Levitsky