Abstract: In various embodiments, a surgical instrument can comprise an end effector including a staple cartridge and a datum portion positioned proximal to the staple cartridge. The surgical instrument can further comprise a shaft and an articulation joint configured to articulate the end effector relative to the shaft. In addition, the surgical instrument can further comprise a firing member configured to deploy a plurality of staples from the staple cartridge and a drive assembly including a drive member configured to move the firing member. The drive assembly may also include a stop configured to engage the datum portion to limit the movement of the drive member after the plurality of staples are fired.

Abstract: Provided herein are antisense oligonucleotides and compositions that include the disclosed ASOs. The disclosed ASOs and compositions can be used for treating hepatitis B.

Abstract: A surgical system is disclosed. The surgical system comprises an end effector configured to move through a grasping motion, a motor configured to drive the grasping motion, an encoder configured to detect rotary positions, a load sensor configured to detect loads delivered, a position sensor configured to detect three-dimensional positions of the end effector, and a control circuit configured to receive a position parameter, a rotary parameter, and a load parameter, store the position parameter at the outset of the grasping motion, calculate an amount of work performed during the grasping motion while the position sensor detects the position of the end effector within a three-dimensional zone around the stored position parameter, transmit a work signal indicative of the amount of work performed, and reset the calculation of the amount of work performed when the position sensor detects a displacement of the end effector out of the three-dimensional zone.

Abstract: Systems and methods for measuring a temperature at a location within a patient's body such as at an in vivo location proximate to a site of intravenous fluid administration, are disclosed. In some embodiments, an insertable device includes an insertion tube member having a tip configured to be inserted into a blood vessel (or other body lumen) of a patient, and a temperature sensor operatively coupled to the insertion tube proximate the tip and configured to measure a temperature within the blood vessel during administration of a fluid through the insertion tube. The device may also include a controller operable to receive one or more signals from the temperature sensor indicative of the temperature within the blood vessel proximate the tip of the insertion tube.

Abstract: In various embodiments, a surgical instrument can comprise an end effector including a staple cartridge and a datum portion positioned proximal to the staple cartridge. The surgical instrument can further comprise a shaft and an articulation joint configured to articulate the end effector relative to the shaft. In addition, the surgical instrument can further comprise a firing member configured to deploy a plurality of staples from the staple cartridge and a drive assembly including a drive member configured to move the firing member. The drive assembly may also include a stop configured to engage the datum portion to limit the movement of the drive member after the plurality of staples are fired.

Abstract: In various embodiments, a surgical instrument can comprise an end effector including a staple cartridge and a datum portion positioned proximal to the staple cartridge. The surgical instrument can further comprise a shaft and an articulation joint configured to articulate the end effector relative to the shaft. In addition, the surgical instrument can further comprise a firing member configured to deploy a plurality of staples from the staple cartridge and a drive assembly including a drive member configured to move the firing member. The drive assembly may also include a stop configured to engage the datum portion to limit the movement of the drive member after the plurality of staples are fired.

Abstract: A surgical system is disclosed. The surgical system comprises an end effector configured to move through a grasping motion, a motor configured to drive the grasping motion, an encoder configured to detect rotary positions, a load sensor configured to detect loads delivered, a position sensor configured to detect three-dimensional positions of the end effector, and a control circuit configured to receive a position parameter, a rotary parameter, and a load parameter, store the position parameter at the outset of the grasping motion, calculate an amount of work performed during the grasping motion while the position sensor detects the position of the end effector within a three-dimensional zone around the stored position parameter, transmit a work signal indicative of the amount of work performed, and reset the calculation of the amount of work performed when the position sensor detects a displacement of the end effector out of the three-dimensional zone.

Abstract: Techniques and technologies for guiding medical instruments during medical procedures using real-time imaging technologies are disclosed. A representative apparatus includes a medical instrument, an imaging system, a stage assembly, and a control system. The medical instrument includes an elongated portion configured to be inserted into a body portion and having an optical fiber that includes a tip portion that is extendable beyond a distal end of the elongated portion. The imaging system provides a sampling energy that is emitted from the tip portion. The stage assembly actuates the tip portion to perform scanning of one or more tissues with the sampling energy. The imaging system receives a reflected energy, providing a plurality of one-dimensional arrays of intensity values of the reflected energy.

Abstract: In various embodiments, a surgical instrument can comprise an end effector including a staple cartridge and a datum portion positioned proximal to the staple cartridge. The surgical instrument can further comprise a shaft and an articulation joint configured to articulate the end effector relative to the shaft. In addition, the surgical instrument can further comprise a firing member configured to deploy a plurality of staples from the staple cartridge and a drive assembly including a drive member configured to move the firing member. The drive assembly may also include a stop configured to engage the datum portion to limit the movement of the drive member after the plurality of staples are fired.

Abstract: A surgical system comprising a housing assembly, a shaft extending from the housing assembly, a closure system, an end effector extending from the shaft, and a rotation system is disclosed. The housing assembly comprises a motor. The end effector is configurable in an unclamped configuration and a clamped configuration. The end effector is moved into the clamped configuration by the closure system. The end effector comprises a staple cartridge and a firing member. The staple cartridge comprises a plurality staples. The firing member is configured to move through the staple cartridge and deploy the plurality of staples. The rotation system is configured to rotate the end effector about a rotation axis when the end effector is in the unclamped configuration and prevent the end effector from rotating about the rotation axis when the end effector is in the clamped configuration.

Abstract: Surgical end effectors are disclosed. The surgical end effectors can include a first jaw, a second jaw, and a firing member configured to translate relative to the first jaw and the second jaw during a firing stroke. The firing member can include at least one floating flange. The floating flange can be configured to shift or slide relative to a fixed portion of the firing member such as a fixed flange.

Abstract: A surgical instrument comprising a first jaw, a second jaw, and a firing member is disclosed. The firing member comprises one or more cams configured to position the first jaw relative to the second jaw. In various instances, one of the cams is oriented at a non-parallel angle relative to another cam in order to reduce strain within the cams. In certain instances, at least one of the cams comprises a leading projection and a trailing projection positioned behind the leading projection which are configured to engage the same jaw. The ends of the leading projection and the trailing projection are not attached to one another and can move relative to one another. In some instances, one or more of the cams has a plastically deformable or wearable feature configured to facilitate multiple uses of the surgical instrument.

Abstract: A surgical instrument with separate actuatable closure and firing systems for closing a movable jaw and actuating a firing member. In one form, the surgical instrument comprises an elastic spine assembly that includes a proximal spine portion and a distal spine portion that is elastically coupled to the proximal spine portion for axial movement relative thereto between a neutral position and an elongated position such that during actuation of the firing system results in an increased application of closure motions to the movable jaw without actuating the closure system.

Abstract: A surgical instrument with separate actuatable closure and firing systems for closing a movable jaw and actuating a firing member. In one form, the surgical instrument comprises an elastic spine assembly that includes a proximal spine portion and a distal spine portion that is elastically coupled to the proximal spine portion for axial movement relative thereto between a neutral position and an elongated position such that during actuation of the firing system results in an increased application of closure motions to the movable jaw without actuating the closure system.

Abstract: A surgical instrument comprising a first jaw, a second jaw, and a firing member is disclosed. The firing member comprises one or more cams configured to position the first jaw relative to the second jaw. In various instances, one of the cams is oriented at a non-parallel angle relative to another cam in order to reduce strain within the cams. In certain instances, at least one of the cams comprises a leading projection and a trailing projection positioned behind the leading projection which are configured to engage the same jaw. The ends of the leading projection and the trailing projection are not attached to one another and can move relative to one another. In some instances, one or more of the cams has a plastically deformable or wearable feature configured to facilitate multiple uses of the surgical instrument.

Abstract: Surgical end effectors are disclosed. The surgical end effectors can include a first jaw, a second jaw, and a firing member configured to translate relative to the first jaw and the second jaw during a firing stroke. The firing member can include at least one floating flange. The floating flange can be configured to shift or slide relative to a fixed portion of the firing member such as a fixed flange.

Abstract: In various embodiments, a surgical instrument can comprise an end effector including a staple cartridge and a datum portion positioned proximal to the staple cartridge. The surgical instrument can further comprise a shaft and an articulation joint configured to articulate the end effector relative to the shaft. In addition, the surgical instrument can further comprise a firing member configured to deploy a plurality of staples from the staple cartridge and a drive assembly including a drive member configured to move the firing member. The drive assembly may also include a stop configured to engage the datum portion to limit the movement of the drive member after the plurality of staples are fired.

Abstract: In various embodiments, a surgical instrument can comprise an end effector including a staple cartridge and a datum portion positioned proximal to the staple cartridge. The surgical instrument can further comprise a shaft and an articulation joint configured to articulate the end effector relative to the shaft. In addition, the surgical instrument can further comprise a firing member configured to deploy a plurality of staples from the staple cartridge and a drive assembly including a drive member configured to move the firing member. The drive assembly may also include a stop configured to engage the datum portion to limit the movement of the drive member after the plurality of staples are fired.

Abstract: A shirt has a lens cloth for cleaning eyeglass lenses. The shirt is particularly useful for cleaning eyeglasses and sunglasses while boating and fishing. The lens cloth is disposed on an inside surface of the shirt so the lens cloth is not exposed to dirt, rain, and sea spray. The lens cloth can be placed on the interior of the torso of the shirt. The lens cloth extends upward from the bottom hemline of the front of the shirt. The lens cloth can reach a height that is lower than the waistline of the pants of a wearer. In this way, the lens cloth does not overly the skin of the wearer and remains clear of perspiration and sunscreen. To use the lens cloth, the front tail of the shirt is folded backward to expose the underlying lens cloth. In addition, a pocket can be formed on the shirt with a lens cloth held within the pocket. The lens cloth is kept clean by folding the lens cloth into the pocket.

Abstract: In various embodiments, a surgical instrument can comprise an end effector including a staple cartridge and a datum portion positioned proximal to the staple cartridge. The surgical instrument can further comprise a shaft and an articulation joint configured to articulate the end effector relative to the shaft. In addition, the surgical instrument can further comprise a firing member configured to deploy a plurality of staples from the staple cartridge and a drive assembly including a drive member configured to move the firing member. The drive assembly may also include a stop configured to engage the datum portion to limit the movement of the drive member after the plurality of staples are fired.