Abstract: A putter head for a golf putter is provided. The putter head comprises a body and insert. The body comprises a base; a face portion having a ball-facing surface with a non-zero first loft angle A; a window framed by the ball-facing surface and extending through the face portion; and an open-topped dock extending into the base rearwardly from the window. The insert is removably affixable to the body. The insert comprises: an insert body having a ball strike face with a second loft angle in the range of: 0 to A; and a foot extending rearwardly from the insert body. The foot is dimensioned to be inserted through the window and seated in the open-topped dock. The insert body is dimensioned to be received by and seated within the window.

Abstract: A system for modeling the evolution of a system over time using an advection-based process is provided. The system continuously evolves a probability density function (“PDF”) for a characteristic of a characteristic of the state of the system and its time-varying parameters. The PDF is evolved based on advection by solving an advection partial differential equation that is based on a system model of the system. The system model has time-varying parameters for modeling the characteristic of the state of the system. The system uses the continuously evolving PDF to make predictions out the characteristic of the state of the system.

Abstract: Methods, probe arrays and computer software products are provided for determining the arrangement of sequence elements. In one embodiment, methods for making and using exon chips are provided. The exon chips may be used to identify and quantify splice variants.

Abstract: A mechanistic model was developed to extract meaningful thermodynamic and kinetic parameters from an irreversibly denatured process. As a result, methods and computer apparatus have been created that can be used to mathematically determine parameters that are predictive of aggregation kinetics of biologically active materials. Those parameters can then be used to predict stability or aggregation kinetics as a function of time and temperature.

Abstract: A fluorescent lampholder with a top portion for supporting a fluorescent lamp and a base portion with a wire opening located on the bottom surface of the base that receives wires without exposing the wires to the exterior surface of a fixture. The lampholder is capable of supporting various types and/or sizes of fluorescent lamps such as “tall”, “medium” and “small” T-8 fluorescent lamps as well as other types and/or sizes of fluorescent lamps.

Abstract: Innovative systems and methods for visualizing information collected from analyzing samples are provided. The samples may include nucleic acids, proteins, or other polymers. Gene expression level as determined from analysis of a nucleic acid sample is one possible analysis result that may be visualized. In one embodiment, a computer system may display the expression levels of multiple genes simultaneously in a way that facilitates user identification of genes whose expression is significant to a characteristic such as disease or resistance to disease. Additionally, the computer system may facilitate display of further information about relevant genes once they are identified.

Abstract: According to the invention, a system and method for organizing expression information in a way that facilitates data mining. A database model is provided which may organize information relating to, e.g., sample preparation, expression analysis of experiment results, and intermediate and final results of mining expression and concentration results. The model is readily translatable into database languages such as SQL and the like. The database model scales to permit mining of expression or concentration information collected from large numbers of samples.

Abstract: Systems and method for organizing information relating to the design of polymer probe array chips including oligonucleotide array chips. A database model is provided which organizes information interrelating probes on a chip, genomic items investigated by the chip, and sequence information relating to the design of the chip. The model is readily translatable into database languages such as SQL. The database model scales to permit storage of information about large numbers of chips having complex designs.

Abstract: A postural assessment chair provides a device for monitoring the posture of an individual seated thereon, and correlating changes in the individual's posture, along with indicia of movement of the chair itself and the cognitive workload of the individual, to determine the mental engagement of the individual.

Abstract: Methods, probe arrays and computer software products are provided for determining the arrangement of sequence elements. In one embodiment, methods for making and using exon chips are provided. The exon chips may be used to identify and quantify splice variants.

Abstract: Methods and computer software products are provided for analyzing gene expression data In one embodiment, multiple probes are used to detect a single transcript The hybridization intensities of each probe is adjusted by dividing the intensities by the affinities of the probes The minimal adjusted hybridization intensity may be used as the measurement of the gene expression

Abstract: Disclosed are methods for analyzing molecular binding events in which the formation of ligand/antiligand complexes can be directly detected in a mixture without requiring separation of the components of the mixture from each other by measuring bulk properties of the mixture (i.e., properties that have contributions from several or all of the components present in the mixture). Using these techniques, it is possible to screen libraries without labeling either the target antiligand or ligand. The invention also provides a method for determining the strength of ligand/antiligand binding by further analysis of the same signals.

Abstract: Methods and computer software products are provided for analyzing gene expression data. In one embodiment, multiple probes are used to detect a single transcript. The hybridization intensities of each probe is adjusted by dividing the intensities by the affinities of the probes. The minimal adjusted hybridization intensity may be used as the measurement of the gene expression.

Abstract: A lamp adapter for receiving a lamp having a conductive threaded portion and an extension with a conductive contact electrically insulated from the conductive threaded portion. The lamp adapter has a body with a top portion and a bottom portion. The top portion has a socket with a threaded sleeve adapted to receive the threaded portion of the lamp, a first lead electrically connected to the threaded sleeve, a cavity located with respect to the threaded sleeve so as to receive the extension of the lamp when the lamp is threaded into the threaded sleeve, a metal contact arm located within the cavity so as to make electrical contact with the conductive contact of the lamp when the lamp is threaded into the threaded sleeve, and a second lead electrically connected to the metal contact arm. The bottom portion has a threaded portion suitable for threading into a mating lamp socket, the threaded portion being electrically insulated from the top portion.

Abstract: A system and method for the alignment of an insulation piercing contact within a two piece switch housing with an insulated electrical wires disposed within the housing. The housing is comprised of two halves whereby when the two halves are brought together during assembly, the insulation piercing contact pierces the insulation of the electrical wires and forms an electrical connection between the contact and the wires. Proper alignment between the insulation piercing contact and the insulated electrical wires is ensured by providing extended prongs on one half of the switch housing. On the other half of the switch housing, channels are provided and arranged to slidably engage and mate with the prongs prior to contact of the electrical wires with the piercing contact. The prongs and channels fix the relative alignment of the contact with the wire before piercing occurs and ensures consistent location of the electrical connection formed during assembly of the switch housing.

Abstract: A four function electrical rocker switch has two single pole, single throw on/off sections having their movable contact arms coupled to a single electrical line and their screw terminal fixed contacts connected to individual circuits. The two switch sections are independently operated. A third rocker switch is a single pole, double throw switch with a center-off position. The third switch can be operated to either of two positions to operate either one of two independent circuits or can be left in the center-off position not engaging either circuit. A five function electrical rocker switch can be made up of one section having a single pole, single throw on/off switch and two sections with single pole, double throw switches which each have a center-off position.

Abstract: Methods, probe arrays and computer software products are provided for determining the arrangement of sequence elements. In one embodiment, methods for making and using exon chips are provided. The exon chips may be used to identify and quantify splice variants.

Abstract: Systems and methods for organizing information relating to study of polymorphisms. A database model is provided which interrelates information about one or more of, e.g, subjects from whom samples are extracted, primers used in extracting the DNA from the subjects, about the samples themselves, about experiments done on samples, about particular oligonucleotide probe arrays used to perform experiments, about analysis procedures performed on the samples, and about analysis results. The model is readily translatable into database languages such as SQL. The database model scales to permit storage of information about large numbers of subjects, samples, experiments, chips, etc.

Abstract: System and method for organizing information relating to polymer probe array chips including oligonucleotide array chips. A database model is provided which organizes information relating to sample preparation, chip layout, application of samples to chips, scanning of chips, expression analysis of chip results, etc. The model is readily translatable into database languages such as SQL. The database model scales to permit mass processing of probe array chips.

Abstract: Systems and method for organizing information relating to the design of polymer probe array chips including oligonucleotide array chips. A database model is provided which organizes information interrelating probes on a chip, genomic items investigated by the chip, and sequence information relating to the design of the chip. The model is readily translatable into database languages such as SQL. The database model scales to permit storage of information about large numbers of chips having complex designs.