Abstract: Techniques for monitoring operating statuses of an application and its dependencies are provided. A monitoring application may collect and report the operating status of the monitored application and each dependency. Through use of existing monitoring interfaces, the monitoring application can collect operating status without requiring modification of the underlying monitored application or dependencies. The monitoring application may determine a problem service that is a root cause of an unhealthy state of the monitored application. Dependency analyzer and discovery crawler techniques may automatically configure and update the monitoring application. Machine learning techniques may be used to determine patterns of performance based on system state information associated with performance events and provide health reports relative to a baseline status of the monitored application. Also provided are techniques for testing a response of the monitored application through modifications to API calls.

Abstract: A method of generating customizable goal representation is disclosed. A request from a user to view a goal representation is received. A flexible goal ontology is accessed that comprises one or more goal entities, one or more goal relationships between the goal entities, or one or more goal properties, the one or more goal properties including one or more metadata attributes relating to the one or more goal entities. A set of mapping rules is obtained that defines mappings between one or more goals. The set of mapping rules is evaluated to assemble a customized goal representation tailored to the user. The customized goal representation is updated based on a revaluation of the mapping rules affected by changes to the one or more goal entities, the one or more goal relationships, or the one or more properties.

Abstract: Provided herein are methods, systems, and compositions for determining a base in a polynucleotide. In various aspects, the methods, systems, and compositions presented herein are useful for performing 4-base, 5-base, or 6-base sequencing of polynucleotide molecules, for example, from liquid biopsy samples or wherein the base is a low frequency mutation.

Abstract: An actuator for operating a valve comprises a housing, a cap, a ring and a piston. The housing has a connecting interface for being mounted on the valve. The cap substantially covers a first portion of the housing. Both the cap and the housing define a substantially enclosed space inside the housing. The ring sealably covers a second portion of the housing. The ring is equipped with two ports that are in fluid communication with the enclosed space. The piston is slidably located inside the housing. Advantageously, an actuator assembly may include the actuator as previously described and one bonnet, one of the connecting interfaces of the actuator being connected to the bonnet. The bonnet is adapted to be mounted to a valve body.

Abstract: An actuator for operating a valve comprises a housing, a cap, a ring and a piston. The housing has a connecting interface for being mounted on the valve. The cap substantially covers a first portion of the housing. Both the cap and the housing define a substantially enclosed space inside the housing. The ring sealably covers a second portion of the housing. The ring is equipped with two ports that are in fluid communication with the enclosed space. The piston is slidably located inside the housing. Advantageously, an actuator assembly may include the actuator as previously described and one bonnet, one of the connecting interfaces of the actuator being connected to the bonnet. The bonnet is adapted to be mounted to a valve body.