Patents by Inventor David Bar-Or

David Bar-Or has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12285541
    Abstract: The present disclosure provides methods and compositions comprising hyaluronic acid (HA) hydrogel in combination with a saturated fatty acid for treating osteoarthritis. In some embodiments, aspects of the disclosure relate to pharmaceutical compositions comprising HA hydrogel in combination with a steroid. In some embodiments, the pharmaceutical compositions may be administrable via local, topical, and injection. In some embodiments, the pharmaceutical composition may be administrable by intra-articular injection.
    Type: Grant
    Filed: January 26, 2024
    Date of Patent: April 29, 2025
    Assignee: INSIGNIA PHARMACEUTICALS, LLC
    Inventors: David Bar-Or, Gregory Thomas, Melissa Hausburg, Jason Williams, Raphael Bar-Or
  • Publication number: 20250082822
    Abstract: The present disclosure provides methods and compositions comprising hyaluronic acid (HA) hydrogel in combination with a saturated fatty acid for treating osteoarthritis. In some embodiments, aspects of the disclosure relate to pharmaceutical compositions comprising HA hydrogel in combination with a steroid. In some embodiments, the pharmaceutical compositions may be administrable via local, topical, and injection. In some embodiments, the pharmaceutical composition may be administrable by intra-articular injection.
    Type: Application
    Filed: November 26, 2024
    Publication date: March 13, 2025
    Applicant: INSIGNIA PHARMACEUTICALS, LLC
    Inventors: David BAR-OR, Gregory THOMAS, Melissa HAUSBURG, Jason WILLIAMS, Raphael BAR-OR
  • Publication number: 20240423957
    Abstract: Various aspects of this disclosure relate to topical anti-inflammatory, analgesic compositions comprising a fatty acid and tryptophan as well as methods of using such compositions. In some specific embodiments, the fatty acid is decanoic acid. Such compositions are generally useful to treat inflammation, and they are specifically useful to treat osteoarthritis.
    Type: Application
    Filed: June 17, 2024
    Publication date: December 26, 2024
    Applicant: INSIGNIA PHARMACEUTICALS, LLC
    Inventors: David Bar-Or, Raphael Bar-Or
  • Publication number: 20240252715
    Abstract: The present disclosure provides methods and compositions comprising hyaluronic acid (HA) hydrogel in combination with a saturated fatty acid for treating osteoarthritis. In some embodiments, aspects of the disclosure relate to pharmaceutical compositions comprising HA hydrogel in combination with a steroid. In some embodiments, the pharmaceutical compositions may be administrable via local, topical, and injection. In some embodiments, the pharmaceutical composition may be administrable by intra-articular injection.
    Type: Application
    Filed: January 26, 2024
    Publication date: August 1, 2024
    Applicant: INSIGNIA PHARMACEUTICALS, LLC
    Inventors: David BAR-OR, Gregory THOMAS, Melissa HAUSBURG, Jason WILLIAMS, Raphael BAR-OR
  • Patent number: 11478441
    Abstract: The invention provides a method, composition and kit for treating T-cell mediated diseases, degenerative joint diseases or diseases mediated by platelet activating factor (PAF) comprising administering to an animal in need thereof, an effective amount a pharmaceutical composition containing N-acetyl-kynurenine (NAK) or pharmaceutically acceptable salts thereof as the active ingredient.
    Type: Grant
    Filed: September 17, 2020
    Date of Patent: October 25, 2022
    Assignee: Ampio Pharmaceuticals, Inc.
    Inventors: David Bar-Or, Leonard T. Rael, Raphael Bar-Or
  • Publication number: 20220288062
    Abstract: The invention provides a method of treating T-cell mediated diseases and a method of inhibiting the activation of T-cells using certain diketopiperazines. The invention also provides methods of synthesizing diketopiperazines and pharmaceutical compositions comprising certain diketopiperazines. The invention further provides methods of making improved pharmaceutical compositions of proteins and peptides by either increasing or decreasing the content of diketopiperazines in the compositions and the resultant improved pharmaceutical compositions.
    Type: Application
    Filed: May 23, 2022
    Publication date: September 15, 2022
    Inventors: David BAR-OR, Raphael BAR-OR, Richard SHIMONKEVITZ
  • Patent number: 11389512
    Abstract: The present invention provides a method of modulating various aspects of the immune system. In particular, the present invention teaches the use of diketopiperazines (DKPs) to modulate various aspects of the immune system such as, for example, inflammation, T-cells and various cytokines.
    Type: Grant
    Filed: June 22, 2016
    Date of Patent: July 19, 2022
    Inventors: David Bar-Or, Elizabeth Frederick, Melissa Hausburg
  • Publication number: 20220211819
    Abstract: The present disclosure provides a method of treating a disease associated with a respiratory virus. The method comprises administering an effective amount of a pharmaceutical composition prepared by removing albumin from a solution of a human serum albumin composition and/or comprising a diketopiperazine with amino acid side chains of aspartic acid and alanine (DA-DKP), such as a low molecular weight fraction of human serum albumin. The present disclosure also provides a pharmaceutical product as well as a kit comprising DA-DKP.
    Type: Application
    Filed: March 21, 2022
    Publication date: July 7, 2022
    Inventors: David Bar-Or, Holli Cherevka
  • Patent number: 11369598
    Abstract: The invention provides a method of treating T-cell mediated diseases and a method of inhibiting the activation of T-cells using certain diketopiperazines. The invention also provides methods of synthesizing diketopiperazines and pharmaceutical compositions comprising certain diketopiperazines. The invention further provides methods of making improved pharmaceutical compositions of proteins and peptides by either increasing or decreasing the content of diketopiperazines in the compositions and the resultant improved pharmaceutical compositions.
    Type: Grant
    Filed: October 1, 2020
    Date of Patent: June 28, 2022
    Assignee: Ampio Pharmaceuticals, Inc.
    Inventors: David Bar-Or, Raphael Bar-Or, Richard Shimonkevitz
  • Patent number: 11278598
    Abstract: The present disclosure provides a method of treating a disease associated with a respiratory virus. The method comprises administering an effective amount of a pharmaceutical composition prepared by removing albumin from a solution of a human serum albumin composition and/or comprising a diketopiperazine with amino acid side chains of aspartic acid and alanine (DA-DKP), such as a low molecular weight fraction of human serum albumin. The present disclosure also provides a pharmaceutical product as well as a kit comprising DA-DKP.
    Type: Grant
    Filed: September 22, 2021
    Date of Patent: March 22, 2022
    Assignee: Ampio Pharmaceuticals, Inc.
    Inventors: David Bar-Or, Holli Cherevka
  • Publication number: 20220016110
    Abstract: The invention provides compositions that increase the mobilization, homing, expansion, and/or differentiation of stem cells and methods of using the same for the treatment of mammals.
    Type: Application
    Filed: May 3, 2021
    Publication date: January 20, 2022
    Inventors: David Bar-Or, Greg Thomas
  • Publication number: 20220008517
    Abstract: The present disclosure provides a method of treating a disease associated with a respiratory virus. The method comprises administering an effective amount of a pharmaceutical composition prepared by removing albumin from a solution of a human serum albumin composition and/or comprising a diketopiperazine with amino acid side chains of aspartic acid and alanine (DA-DKP), such as a low molecular weight fraction of human serum albumin. The present disclosure also provides a pharmaceutical product as well as a kit comprising DA-DKP.
    Type: Application
    Filed: September 22, 2021
    Publication date: January 13, 2022
    Inventors: David Bar-Or, Holli Cherevka
  • Publication number: 20210393851
    Abstract: The present invention relates to the contacting of one or more surfaces of an implantable medical device with one or more diketopiperazines (DKPs).
    Type: Application
    Filed: June 28, 2021
    Publication date: December 23, 2021
    Inventor: David Bar-Or
  • Publication number: 20210330668
    Abstract: The invention provides a method of treating a joint condition. The method comprises administering a multi-dose regimen of a pharmaceutical composition comprising a diketopiperazine with amino acid side chains of aspartic acid and alanine (DA-DKP). The invention also provides a method of treating osteoarthritis with multiple doses of a low-molecular weight fraction of human serum albumin.
    Type: Application
    Filed: July 8, 2021
    Publication date: October 28, 2021
    Inventor: David Bar-Or
  • Publication number: 20210308230
    Abstract: The present disclosure provides a method of treating a disease associated with a respiratory virus. The method comprises administering an effective amount of a pharmaceutical composition prepared by removing albumin from a solution of a human serum albumin composition and/or comprising a diketopiperazine with amino acid side chains of aspartic acid and alanine (DA-DKP), such as a low molecular weight fraction of human serum albumin. The present disclosure also provides a pharmaceutical product as well as a kit comprising DA-DKP.
    Type: Application
    Filed: March 24, 2021
    Publication date: October 7, 2021
    Inventors: David Bar-Or, Holli Cherevka
  • Patent number: 11129878
    Abstract: The present disclosure provides a method of treating a disease associated with a respiratory virus. The method comprises administering an effective amount of a pharmaceutical composition prepared by removing albumin from a solution of a human serum albumin composition and/or comprising a diketopiperazine with amino acid side chains of aspartic acid and alanine (DA-DKP), such as a low molecular weight fraction of human serum albumin. The present disclosure also provides a pharmaceutical product as well as a kit comprising DA-DKP.
    Type: Grant
    Filed: March 24, 2021
    Date of Patent: September 28, 2021
    Assignee: AMPIO PHARMACEUTICALS, INC.
    Inventors: David Bar-Or, Holli Cherevka
  • Patent number: 11090301
    Abstract: The invention provides a method of treating a joint condition. The method comprises administering a multi-dose regimen of a pharmaceutical composition comprising a diketopiperazine with amino acid side chains of aspartic acid and alanine (DA-DKP). The invention also provides a method of treating osteoarthritis with multiple doses of a low-molecular weight fraction of human serum albumin.
    Type: Grant
    Filed: May 20, 2019
    Date of Patent: August 17, 2021
    Assignee: Ampio Pharmaceuticals, Inc.
    Inventor: David Bar-Or
  • Patent number: 11058798
    Abstract: The present invention relates to the contacting of one or more surfaces of an implantable medical device with one or more diketopiperazines (DKPs).
    Type: Grant
    Filed: September 19, 2019
    Date of Patent: July 13, 2021
    Assignee: Ampio Pharmaceuticals, Inc.
    Inventor: David Bar-Or
  • Patent number: 11026940
    Abstract: The invention provides compositions that increase the mobilization, homing, expansion, and/or differentiation of stem cells and methods of using the same for the treatment of mammals.
    Type: Grant
    Filed: October 3, 2017
    Date of Patent: June 8, 2021
    Assignee: Ampio Pharmaceuticals, Inc.
    Inventors: David Bar-Or, Greg Thomas
  • Publication number: 20210121457
    Abstract: The invention provides a method of treating T-cell mediated diseases and a method of inhibiting the activation of T-cells using certain diketopiperazines. The invention also provides methods of synthesizing diketopiperazines and pharmaceutical compositions comprising certain diketopiperazines. The invention further provides methods of making improved pharmaceutical compositions of proteins and peptides by either increasing or decreasing the content of diketopiperazines in the compositions and the resultant improved pharmaceutical compositions.
    Type: Application
    Filed: October 1, 2020
    Publication date: April 29, 2021
    Inventors: David Bar-Or, Raphael Bar-Or, Richard Shimonkevitz