Abstract: Compositions and methods for treating fibrosis using oligonucleotide-based therapies are provided. These therapies can be used to increase expression of Bone morphogenetic protein receptor type II (BMPR2) via inhibition of upstream Open Reading Frames, thereby reducing vasoconstriction, vascular remodeling, and formation of fibrosis, particularly pulmonary arterial fibrosis related in patients in need thereof.

Abstract: An example of a CPR data recording system includes a hand-held chest compression measurement device and an external computing device communicatively coupled to the hand-held chest compression measurement device. The hand-held chest compression measurement device includes a housing, a motion sensor, a communication device, a memory disposed within the housing, and a processor disposed within the housing. The processor is configured to process a signal output from the motion sensor, calculate chest compression data from the processed signal output, evaluate the chest compression data after a delay from a start of the chest compressions to identify chest compressions that satisfy a pre-determined quality criterion, record the chest compression data in the memory, and send the recorded chest compression data to the external computing device via the communication device. The external computing device is configured to enable a review of the chest compression data.

Abstract: A community based response system for providing lay responders to cardiac arrest emergencies is configured to receive a notification of a cardiac arrest emergency including a location of a cardiac arrest victim, provide an automatic alert to portable devices in a vicinity of the victim, the automatic alert including a selectable control that enables user interoperation with the system, receive an indication from a lay responder, via a respective portable device, that the lay responder will proceed to the location of the victim, and in response to the indication that the lay responder will proceed to the location of the victim, provide at a display screen of the portable device associated with the lay responder a map including the victim's location relative to the lay responder, and a navigational route to guide the lay responder to the victim, and a dispatch text message notification.

Abstract: An example of a medical equipment and responder management system is configured to register potential responders to an emergency event, receive event information including an event location and an event type, provide an automatic notification that includes the event information and mapping information to first and second mobile computing devices associated with first responder and second responders selected from the potential responders, receive a confirmation that the first responder will bring a first item of registered medical equipment to the event, and provide an indication to the second mobile device that the second responder should proceed to the event without the first item of equipment, where the mapping information indicates a location of the first item of equipment located near a first mobile device current location and the current locations of the first and second mobile devices relative to the locations of the event and the first item of equipment.

Abstract: A system for improving cardiac output of a patient suffering from pulseless electrical activity or shock and yet displays myocardial wall motion including: a sensor to detect myocardial activity to determine the presence of residual left ventricular pump function having a contraction or ejection phase and a filling or relaxation phase, a device to prompt the application of or apply a compressive force repeatedly applied to the chest based on the sensed myocardial activity such that the compressive force is applied during at least some of the ejection phases and is ceased during at least some of the relaxation phases to permit residual cardiac filling, thereby enhancing cardiac output and organ perfusion.

Abstract: An example of a CPR data recording system includes a hand-held chest compression measurement device and an external computing device communicatively coupled to the hand-held chest compression measurement device. The hand-held chest compression measurement device includes a housing, a motion sensor, a communication device, a memory disposed within the housing, and a processor disposed within the housing. The processor is configured to process a signal output from the motion sensor, calculate chest compression data from the processed signal output, evaluate the chest compression data after a delay from a start of the chest compressions to identify chest compressions that satisfy a pre-determined quality criterion, record the chest compression data in the memory, and send the recorded chest compression data to the external computing device via the communication device. The external computing device is configured to enable a review of the chest compression data.

Abstract: A resuscitation device for assisting a rescuer in resuscitating a patient. A handheld computing/communication device may be configured for performing a non-resuscitation function during time periods when resuscitation is not required, the handheld device may be further configured to provide CPR prompts during time periods when used by a rescuer to assist in resuscitation, and a sensor may be provided to measure a parameter (e.g., chest acceleration) relevant to resuscitation. A CPR-assistance element may be configured to be applied to the patient and to communicate with the handheld computing/communication device.

Abstract: A chest compression monitor for measuring the depth of chest compressions achieved during CPR. A displacement detector produces a displacement signal indicative of the displacement of the CPR recipient's chest toward the recipient's spine. A signaling mechanism provides chest compression indication signals prompting a CPR provider to provide a chest compression force at a desired depth and rate. The device is held to the dorsal surface of the hand during use and provides a display for feedback, which is readily visible to the CPR provider.

Abstract: An example of a medical equipment and responder management system is configured to register potential responders to an emergency event, receive event information including an event location and an event type, provide an automatic notification that includes the event information and mapping information to first and second mobile computing devices associated with first responder and second responders selected from the potential responders, receive a confirmation that the first responder will bring a first item of registered medical equipment to the event, and provide an indication to the second mobile device that the second responder should proceed to the event without the first item of equipment, where the mapping information indicates a location of the first item of equipment located near a first mobile device current location and the current locations of the first and second mobile devices relative to the locations of the event and the first item of equipment.

Abstract: An example of a medical equipment management system includes a notification system, separate from a dispatch center, that is configured to post a Internet accessible application, receive responder enrollment information prior to an emergency event from a user interface of the application, associate the responder with an account for sending information to a mobile device, receive, from the dispatch center, an emergency location, receive, a current location from the mobile device, receive equipment locations for registered medical equipment, and based on the emergency location, the equipment locations, and the current mobile device location, provide to the mobile computing device, an automatic notification that includes the emergency event information and mapping information that indicates a location of registered medical equipment that is located near the current mobile device location, and the current mobile device location relative to the emergency location and relative to the registered medical equipment lo

Abstract: A system for improving cardiac output of a patient suffering from pulseless electrical activity or shock and yet displays myocardial wall motion including: a sensor to detect myocardial activity to determine the presence of residual left ventricular pump function having a contraction or ejection phase and a filling or relaxation phase, a device to prompt the application of or apply a compressive force repeatedly applied to the chest based on the sensed myocardial activity such that the compressive force is applied during at least some of the ejection phases and is ceased during at least some of the relaxation phases to permit residual cardiac filling, thereby enhancing cardiac output and organ perfusion.

Abstract: A system for improving cardiac output of a patient suffering from pulseless electrical activity or shock and yet displays myocardial wall motion including: a sensor to detect myocardial activity to determine the presence of residual left ventricular pump function having a contraction or ejection phase and a filling or relaxation phase, a device to prompt the application of or apply a compressive force repeatedly applied to the chest based on the sensed myocardial activity such that the compressive force is applied during at least some of the ejection phases and is ceased during at least some of the relaxation phases to permit residual cardiac filling, thereby enhancing cardiac output and organ perfusion.

Abstract: An example of a medical equipment management system includes a notification system, separate from a dispatch center, that is configured to post a Internet accessible application, receive responder enrollment information prior to an emergency event from a user interface of the application, associate the responder with an account for sending information to a mobile device, receive, from the dispatch center, an emergency location, receive, a current location from the mobile device, receive equipment locations for registered medical equipment, and based on the emergency location, the equipment locations, and the current mobile device location, provide to the mobile computing device, an automatic notification that includes the emergency event information and mapping information that indicates a location of registered medical equipment that is located near the current mobile device location, and the current mobile device location relative to the emergency location and relative to the registered medical equipment lo

Abstract: A computer-implemented method for communicating information to medical responders includes registering a plurality of individuals as potential responders for medical problems, receiving at a central service an indication that a person is having a medical problem and receiving information that identifies a current location of the person, and identifying, from among the registered plurality of individuals, one or more registered individuals who are currently in close proximity to the person having a medical problem. The method also includes transmitting, to the one or more registered individuals, information that identifies the location of the person having a medical problem. The one or more individuals comprise lay responders who are not assigned responsibility to provide lifesaving services in an area around the current location of the person.

Abstract: A system for improving performance of chest compressions includes at least one mobile computing device, an accelerometer configured to measure a vertical displacement of a user's hands to determine information relating to rate and depth of chest compressions, and a processor; and a computer device configured to send information to and receive information from the mobile computing device(s). The system associates the information relating to the rate and depth of the chest compressions with the user; sends the information to the computer device; analyzes the information to determine a proficiency level of the user; compares the proficiency level of the user to a proficiency standard required to be certified in life saving activities; and provides an indication of whether the user of the mobile computing device is ready for certification if the proficiency level of the user meets the proficiency standard. Also, a method for certification is provided.

Abstract: A computer-implemented method for managing rescue training includes registering a plurality of individuals as potential rescue trainees through a central computer server system, receiving from computing devices that are remote from the central server system information indicative of rate and depth of compression for ones of the potential rescue trainees, and generating comparative data that reflects performance of CPR chest compressions for a first rescue trainee against other rescue trainees. The method also includes providing the comparative data over a network for review by one or more of the rescue trainees.

Abstract: A system for improving cardiac output of a patient suffering from pulseless electrical activity or shock and yet displays myocardial wall motion including: a sensor to detect myocardial activity to determine the presence of residual left ventricular pump function having a contraction or ejection phase and a filling or relaxation phase, a device to prompt the application of or apply a compressive force repeatedly applied to the chest based on the sensed myocardial activity such that the compressive force is applied during at least some of the ejection phases and is ceased during at least some of the relaxation phases to permit residual cardiac filling, thereby enhancing cardiac output and organ perfusion.

Abstract: A system for improving cardiac output of a patient suffering from pulseless electrical activity or shock and yet displays myocardial wall motion including: a sensor to detect myocardial activity to determine the presence of residual left ventricular pump function having a contraction or ejection phase and a filling or relaxation phase, a device to prompt the application of or apply a compressive force repeatedly applied to the chest based on the sensed myocardial activity such that the compressive force is applied during at least some of the ejection phases and is ceased during at least some of the relaxation phases to permit residual cardiac filling, thereby enhancing cardiac output and organ perfusion.

Abstract: A chest compression monitor for measuring the depth of chest compressions achieved during CPR. A displacement detector produces a displacement signal indicative of the displacement of the CPR recipient's chest toward the recipient's spine. A signaling mechanism provides chest compression indication signals prompting a CPR provider to provide a chest compression force at a desired depth and rate. The device is held to the dorsal surface of the hand during use and provides a display for feedback, which is readily visible to the CPR provider.

Abstract: A computer-implemented method for managing rescue training includes registering a plurality of individuals as potential rescue trainees through a central computer server system, receiving from computing devices that are remote from the central server system information indicative of rate and depth of compression for ones of the potential rescue trainees, and generating comparative data that reflects performance of CPR chest compressions for a first rescue trainee against other rescue trainees. The method also includes providing the comparative data over a network for review by one or more of the rescue trainees.