Patents by Inventor David Basiji
David Basiji has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9528989Abstract: The use of an imaging system, cell compartment markers, and molecular markers in methods for correlating the movement of molecules within a cell to a particular compartment are provided, including measuring and correlating molecule movement in adherent and non-adherent cells.Type: GrantFiled: March 30, 2012Date of Patent: December 27, 2016Assignee: Amnis CorporationInventors: Thaddeus C. George, David A. Basiji, Keith Frost, Brian E. Hall, William E. Ortyn, Michael J. Seo
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Patent number: 8953866Abstract: Provided are methods for determining and analyzing photometric and morphometric features of small objects, such as cells to, for example, identify different cell states. In particularly, methods are provided for identifying apoptotic cells, and for distinguishing between cells undergoing apoptosis versus necrosis.Type: GrantFiled: April 30, 2012Date of Patent: February 10, 2015Assignee: Amnis CorporationInventors: Thaddeus C. George, David A. Basiji, Brian E. Hall, William E. Ortyn, Michael J. Seo, Philip J. Morrissey, Cathleen A. Zimmerman
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Patent number: 8885913Abstract: An automated identification of the types of white blood cells in a blood sample facilitates the manual identification of cancerous or other abnormal blood cells in the sample. Classifiers are predetermined for each type of white blood cell and subsequently used to automatically process images of cells in a sample stained with a nuclear dye or stain. The classifiers each comprise a linear weighted combination of morphometric and photometric features previously selected for white blood cells that were identified using monoclonal antibody stains. Red blood cells and excess fluid are removed from a sample being processed upstream of an imaging region of the imaging system. A plurality of different types of images are produced for each cell by the imaging system enabling automated identification of the white blood cells. Images of any cells not thus identified are manually reviewed to detect cancerous or abnormal cells.Type: GrantFiled: September 27, 2013Date of Patent: November 11, 2014Assignee: Amnis CorporationInventors: David A. Basiji, William E. Ortyn, Philip J. Morrissey, Vidya Venkatachalam
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Patent number: 8824770Abstract: Provided are methods for determining and analyzing photometric and morphometric features of small objects, such as cells to, for example, identify different cell states. In particularly, methods are provided for identifying apoptotic cells, and for distinguishing between cells undergoing apoptosis versus necrosis.Type: GrantFiled: March 13, 2013Date of Patent: September 2, 2014Assignee: Amnis CorporationInventors: Thaddeus C. George, David A. Basiji, Brian E. Hall, William E. Ortyn, Michael J. Seo, Philip J. Morrissey, Cathleen A. Zimmerman
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Patent number: 8660332Abstract: Multimodal or multispectral images of cells comprising a population of cells are simultaneously collected. Photometric and/or morphometric image features identifiable in the images are used to identify differences between first and second populations of cells. The differences can include changes in a relative percentage of different cell types in each population, or a change in a first type of cell present in the first population of cells and the same type of cell in the second population of cells. The changes may be indicative of a disease state, indicative of a relative effectiveness of a therapy, or indicative of a health of the person from whom the cells populations were obtained.Type: GrantFiled: March 13, 2013Date of Patent: February 25, 2014Assignee: Amnis CorporationInventors: William E. Ortyn, David A. Basiji, Philip J. Morrissey, Thaddeus C. George, Brian E. Hall, Cathleen A. Zimmerman, David J. Perry
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Publication number: 20140030729Abstract: An automated identification of the types of white blood cells in a blood sample facilitates the manual identification of cancerous or other abnormal blood cells in the sample. Classifiers are predetermined for each type of white blood cell and subsequently used to automatically process images of cells in a sample stained with a nuclear dye or stain. The classifiers each comprise a linear weighted combination of morphometric and photometric features previously selected for white blood cells that were identified using monoclonal antibody stains. Red blood cells and excess fluid are removed from a sample being processed upstream of an imaging region of the imaging system. A plurality of different types of images are produced for each cell by the imaging system enabling automated identification of the white blood cells. Images of any cells not thus identified are manually reviewed to detect cancerous or abnormal cells.Type: ApplicationFiled: September 27, 2013Publication date: January 30, 2014Applicant: Amnis CorporationInventors: David A. Basiji, William E. Ortyn, Philip J. Morrissey, Vidya Venkatachalam
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Patent number: 8571295Abstract: Provided are methods for determining and analyzing photometric and morphometric features of small objects, such as cells to, for example, identify different cell states. In particularly, methods are provided for identifying apoptotic cells, and for distinguishing between cells undergoing apoptosis versus necrosis.Type: GrantFiled: March 13, 2013Date of Patent: October 29, 2013Assignee: Amnis CorporationInventors: Thaddeus C. George, David A. Basiji, Brian E. Hall, William E. Ortyn, Michael J. Seo, Philip J. Morrissey, Cathleen A. Zimmerman
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Patent number: 8571294Abstract: Provided are methods for determining and analyzing photometric and morphometric features of small objects, such as cells to, for example, identify different cell states. In particularly, methods are provided for identifying apoptotic cells, and for distinguishing between cells undergoing apoptosis versus necrosis.Type: GrantFiled: November 22, 2011Date of Patent: October 29, 2013Assignee: Amnis CorporationInventors: Thaddeus C. George, David A. Basiji, Brian E. Hall, William E. Ortyn, Michael E. Seo, Phillip J. Morrissey, Cathleen A. Zimmerman
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Patent number: 8548219Abstract: Photometric and morphometric features derived from multi-mode imagery of cells in flow are used as a cell analyzer to determine if a marker corresponding to a cancer cell or precancerous cell is present in the population of cells imaged. An imaging system simultaneously acquires a plurality of images for each cell passing through the field of view of the imaging system. Acquiring a plurality of different images (i.e., bright field, dark field, and fluorescent images) facilitates the determination of different morphological and morphometric parameters. Simultaneously acquiring the plurality of images enables relatively large populations of cells to be rapidly imaged, so that relatively small numbers of cancer cells in a large population of cells can be detected. Initially, known cancer cells are imaged to enable a marker to be identified. Then, a sample that may include cancer cells is imaged to determine if the marker is present.Type: GrantFiled: February 14, 2012Date of Patent: October 1, 2013Assignee: Amnis CorporationInventors: William Ortyn, David Basiji, Luchuan Liang, Vidya Venkatachalam, Philip Morrissey
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Publication number: 20130251234Abstract: Provided are methods for determining and analyzing photometric and morphometric features of small objects, such as cells to, for example, identify different cell states. In particularly, methods are provided for identifying apoptotic cells, and for distinguishing between cells undergoing apoptosis versus necrosis.Type: ApplicationFiled: March 13, 2013Publication date: September 26, 2013Inventors: Thaddeus C. George, David A. Basiji, Brian E. Hall, William E. Ortyn, Michael J. Seo, Philip J. Morrissey, Cathleen A. Zimmerman
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Patent number: 8406498Abstract: Multimodal or multispectral images of cells comprising a population of cells are simultaneously collected. Photometric and/or morphometric image features identifiable in the images are used to identify differences between first and second populations of cells. The differences can include changes in a relative percentage of different cell types in each population, or a change in a first type of cell present in the first population of cells and the same type of cell in the second population of cells. The changes may be indicative of a disease state, indicative of a relative effectiveness of a therapy, or indicative of a health of the person from whom the cells populations were obtained.Type: GrantFiled: December 4, 2009Date of Patent: March 26, 2013Assignee: Amnis CorporationInventors: William Ortyn, David Basiji, Philip Morrissey, Thaddeus George, Brian Hall, Cathleen Zimmerman, David Perry
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Patent number: 8379136Abstract: A system and method for high numeric aperture imaging systems includes a splitter, a defocusing system, and a combiner. The splitter reflects a portion of collected light and transmits another portion of the collected light. The defocusing system is configured to modify optical power of either the transmitted portion or reflected portion of the collected light. The combiner is oriented with respect to a mechanical angle. The combiner recombines portions of the transmitted portion and the reflected portion such that the transmitted portion and reflected portion are subsequently transmitted being separated by an optical separation angle based upon the mechanical angle of orientation of the combiner. Various other implementations are used to maintain focus with regards to the imaging systems involved.Type: GrantFiled: February 14, 2011Date of Patent: February 19, 2013Assignee: Amnis CorporationInventors: William E. Ortyn, David A. Basiji, David J. Perry
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Publication number: 20120328177Abstract: Provided are methods for determining and analyzing photometric and morphometric features of small objects, such as cells to, for example, identify different cell states. In particularly, methods are provided for identifying apoptotic cells, and for distinguishing between cells undergoing apoptosis versus necrosis.Type: ApplicationFiled: April 30, 2012Publication date: December 27, 2012Applicant: AMNIS CORPORATIONInventors: Thaddeus C. George, David A. Basiji, Brian E. Hall, William E. Ortyn, Michael J. Seo, Philip J. Morrissey, Cathleen A. Zimmerman
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Publication number: 20120244550Abstract: The use of an imaging system, cell compartment markers, and molecular markers in methods for correlating the movement of molecules within a cell to a particular compartment are provided, including measuring and correlating molecule movement in adherent and non-adherent cells.Type: ApplicationFiled: March 30, 2012Publication date: September 27, 2012Applicant: AMNIS CORPORATIONInventors: Thaddeus C. George, David A. Basiji, Keith Frost, Brian E. Hall, William E. Ortyn, Michael J. Seo
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Publication number: 20120148142Abstract: Photometric and morphometric features derived from multi-mode imagery of cells in flow are used as a cell analyzer to determine if a marker corresponding to a cancer cell or precancerous cell is present in the population of cells imaged. An imaging system simultaneously acquires a plurality of images for each cell passing through the field of view of the imaging system. Acquiring a plurality of different images (i.e., bright field, dark field, and fluorescent images) facilitates the determination of different morphological and morphometric parameters. Simultaneously acquiring the plurality of images enables relatively large populations of cells to be rapidly imaged, so that relatively small numbers of cancer cells in a large population of cells can be detected. Initially, known cancer cells are imaged to enable a marker to be identified. Then, a sample that may include cancer cells is imaged to determine if the marker is present.Type: ApplicationFiled: February 14, 2012Publication date: June 14, 2012Applicant: Amnis CorporationInventors: William Ortyn, David Basiji, Luchuan Liang, Vidya Venkatachalam, Philip Morrissey
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Patent number: 8175371Abstract: Provided are methods for determining and analyzing photometric and morphogenic features of small objects, such as cells to, for example, identify different cell states. In particularly, methods are provided for identifying apoptotic cells, and for distinguishing between cells undergoing apoptosis versus necrosis.Type: GrantFiled: July 26, 2011Date of Patent: May 8, 2012Assignee: Amnis CorporationInventors: Thaddeus C. George, David A. Basiji, Brian E. Hall, William E. Ortyn, Michael E. Seo, Phillip J. Morrissey, Cathleen A. Zimmerman
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Publication number: 20120100532Abstract: Provided are methods for determining and analyzing photometric and morphometric features of small objects, such as cells to, for example, identify different cell states. In particularly, methods are provided for identifying apoptotic cells, and for distinguishing between cells undergoing apoptosis versus necrosis.Type: ApplicationFiled: November 22, 2011Publication date: April 26, 2012Applicant: AMNIS CORPORATIONInventors: Thaddeus C. George, David A. Basiji, Brian E. Hall, William E. Ortyn, Michael J. Seo, Philip J. Morrissey, Cathleen A. Zimmerman
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Patent number: 8150136Abstract: The use of an imaging system, cell compartment markers, and molecular markers in methods for correlating the movement of molecules within a cell to a particular compartment are provided, including measuring and correlating molecule movement in adherent and non-adherent cells.Type: GrantFiled: March 16, 2005Date of Patent: April 3, 2012Assignee: Amnis CorporationInventors: Thaddeus C. George, David A. Basiji, Keith Frost, Brian E. Hall, William E. Ortyn, Michael J. Seo
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Patent number: 8131053Abstract: Photometric and morphometric features derived from multi-mode imagery of cells in flow are used as a cell analyzer to determine if a marker corresponding to a cancer cell or precancerous cell is present in the population of cells imaged. An imaging system simultaneously acquires a plurality of images for each cell passing through the field of view of the imaging system. Acquiring a plurality of different images (i.e., bright field, dark field, and fluorescent images) facilitates the determination of different morphological and morphometric parameters. Simultaneously acquiring the plurality of images enables relatively large populations of cells to be rapidly imaged, so that relatively small numbers of cancer cells in a large population of cells can be detected. Initially, known cancer cells are imaged to enable a marker to be identified. Then, a sample that may include cancer cells is imaged to determine if the marker is present.Type: GrantFiled: July 28, 2008Date of Patent: March 6, 2012Assignee: Amnis CorporationInventors: William Ortyn, David Basiji, Luchuan Liang, Vidya Venkatachalam, Philip Morrissey
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Patent number: 8103080Abstract: Provided are methods for determining and analyzing photometric and morphogenic features of small objects, such as cells to, for example, identify different cell states. In particularly, methods are provided for identifying apoptotic cells, and for distinguishing between cells undergoing apoptosis versus necrosis.Type: GrantFiled: March 16, 2005Date of Patent: January 24, 2012Assignee: Amnis CorporationInventors: Thaddeus C George, David A Basiji, Brian E Hall, William E Ortyn, Michael J Seo, Philip J Morrissey, Cathleen A Zimmerman