Patents by Inventor David BASSAN

David BASSAN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BICISTRONIC INHIBITORY CHIMERIC ANTIGEN RECEPTOR (ICAR)/ACTIVATING CHIMERIC ANTIGEN RECEPTOR (ACAR) CONSTRUCTS FOR USE IN CANCER THERAPIES
    Publication number: 20240016839
    Abstract: The invention relates to the field of cancer immunotherapy by employing bicistronic inhibitory chimeric antigen receptor (iCAR)/activating chimeric antigen receptor (aCAR) constructs for use in cancer treatment therapies.
    Type: Application
    Filed: September 7, 2021
    Publication date: January 18, 2024
    Inventors: Rick Kendall, Frank Calzone, Orit Foord, Gregor B. Adams, Tanya Kim, David Bassan, Jason Yi, Adi Sharbi-Yunger
  • MAGE-A1 SPECIFIC T CELL RECEPTOR AND USES THEREOF
    Publication number: 20230242611
    Abstract: MAGE-A1 specific T cell receptors (TCRs) are provided. Accordingly, there is provided a TCR comprising a TCR ? chain as set forth in SEQ ID NO: 1 having at least one mutation at an amino acid position selected from the group consisting of S189, G125, W55 and Y56; and/or a TCR ? chain as set forth in SEQ ID NO: 2 having at least one mutation at an amino acid position selected from the group consisting of S32, S109 and T63, the TCR binds a MAGE-A1 peptide as set forth in SEQ ID NO: 25. Also provided are polynucleotides encoding the TCR and T cells expressing same and methods of use thereof.
    Type: Application
    Filed: February 9, 2023
    Publication date: August 3, 2023
    Applicant: Yeda Research and Development Co. Ltd.
    Inventors: Rachel Lea EISENBACH, David BASSAN, Yosi GOZLAN, Esther TZEHOVAL, Nir FRIEDMAN, Erez GREENSTEIN