Patents by Inventor David Bearss

David Bearss has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Protein Kinase Inhibitors
    Publication number: 20080051414
    Abstract: Protein kinase inhibitors are disclosed having utility in the treatment of protein kinase-mediated diseases and conditions, such as cancer. The compounds of this invention have the following structure: including steroisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein A is a ring moiety selected from: and wherein R1, R2, R3, X, Z, L1, Cycl1, L2 and Cycl2 are as defined herein. Also disclosed are compositions containing a compound of this invention, as well as methods relating to the use thereof.
    Type: Application
    Filed: March 1, 2007
    Publication date: February 28, 2008
    Applicants: Arizona Board of Regents on Behalf of The University of Arizona, SuperGen,Inc
    Inventors: Laurence Hurley, Daruka Mahadevan, Haiyong Han, David Bearss, Hariprasad Vankayalapati, Sridevi Bashyam, Ruben Munoz, Steven Warner, Kimiko Della Croce, Daniel Von Hoff, Cory Grand, James Welsh
  • Protein tyrosine phosphatase-prl-1 a a marker and therapeutic target for pancreatic cancer
    Publication number: 20070026398
    Abstract: Using gene expression profiling, the present Invention identifies Protein tyrosine phosphatase IVA member 1 (PRL-1) as a diagnostic marker and therapeutic target for pancreatic cancer. The Invention therefore provides methods for prediction and detection of PRL-1 associated cancers, and evaluation of inhibitors of PRL-1. The Invention also provides a method of treating or preventing pancreatic cancer in a subject.
    Type: Application
    Filed: March 3, 2004
    Publication date: February 1, 2007
    Inventors: Amanda Farnsworth, Haiyong Han, Hariprasad Vankayalapati, Steven Warner, Daniel Von Hoff, David Bearss
  • Inhibitors of polo-like kinase-1
    Publication number: 20060264439
    Abstract: Protein kinase inhibitors are disclosed having utility in the treatment of protein kinase-mediated diseases and conditions, such as cancer. The compounds of this invention have the following structure: including steroisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein ring moiety A, R1, R2, R3, R4, R5, R6, R7, R8 and X are as defined herein. Also disclosed are compositions comprising such compounds and methods of using same.
    Type: Application
    Filed: May 17, 2006
    Publication date: November 23, 2006
    Applicant: SuperGen, Inc.
    Inventors: David Bearss, Hariprasad Vankayalapati, Cory Grand
  • Bone Growth Compositions and Methods
    Publication number: 20060233853
    Abstract: The present invention provides an improved technique for spinal fusion involving the administration of an HMG-CoA reductase inhibitor to a fusion. The HMG-CoA reductase inhibitor is preferably delivered to the site by a carrier. More preferably, the HMG-CoA reductase inhibitor is delivered to the site by a non-compressible delivery vehicle. The invention is suitable for promoting non-anatomic or heterotopic bone growth between any bony surfaces where bone growth is desired but does not naturally occur.
    Type: Application
    Filed: June 2, 2006
    Publication date: October 19, 2006
    Inventors: Benjamin Remington, David Bearss, Kavian Shahi
  • Protein kinase inhibitors
    Publication number: 20050277658
    Abstract: Protein kinase inhibitors are disclosed having utility in the treatment of protein kinase-mediated diseases and conditions, such as cancer. The compounds of this invention have the following structure: including steroisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein A is a ring moiety selected from: and wherein R1, R2, R3, X, Z, L1, Cycl1, L2 and Cycl2 are as defined herein. Also disclosed are compositions containing a compound of this invention, as well as methods relating to the use thereof.
    Type: Application
    Filed: March 29, 2005
    Publication date: December 15, 2005
    Applicants: Arizona Board of Regents on behalf of The University of Arizona, Montigen Pharmaceuticals, Inc.
    Inventors: Laurence Hurley, Daruka Mahadevan, Haiyong Han, David Bearss, Hariprasad Vankayalapati, Sridevi Bashyam, Ruben Munoz, Steven Warner, Kimiko Della Croce, Daniel Von Hoff, Cory Grand
  • Protein kinase inhibitors
    Publication number: 20050239793
    Abstract: Protein kinase inhibitors are disclosed having utility in the treatment of protein kinase-mediated diseases and conditions, such as cancer. The compounds of this invention have the following structure: including steroisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein A is a ring moiety selected from: and wherein R1, R2, R3, X, Z, L1, Cycl1, L2 and Cycl2 are as defined herein. Also disclosed are compositions containing a compound of this invention, as well as methods relating to the use thereof.
    Type: Application
    Filed: March 29, 2005
    Publication date: October 27, 2005
    Applicants: Arizona Board of Regents on behalf of The University of Arizona, Montigen Pharmaceuticals, Inc.
    Inventors: Laurence Hurley, Daruka Mahadevan, Haiyong Han, David Bearss, Hariprasad Vankayalapati, Sridevi Bashyam, Ruben Munoz, Steven Warner, Kimiko Della Croce, Daniel Von Hoff, Cory Grand
  • Protein kinase inhibitors
    Publication number: 20050239794
    Abstract: Protein kinase inhibitors are disclosed having utility in the treatment of protein kinase-mediated diseases and conditions, such as cancer. The compounds of this invention have the following structure: including steroisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein A is a ring moiety selected from: and wherein R1, R2, R3, X, Z, L1, Cycl1, L2 and Cycl2 are as defined herein. Also disclosed are compositions containing a compound of this invention, as well as methods relating to the use thereof.
    Type: Application
    Filed: March 29, 2005
    Publication date: October 27, 2005
    Applicants: Arizona Board of regents on behalf of the University of Arizona, Montigen Pharmaceuticals, Inc.
    Inventors: Laurence Hurley, Daruka Mahadevan, Haiyong Han, David Bearss, Hariprasad Vankayalapati, Sridevi Bashyam, Ruben Munoz, Steven Warner, Kimiko Della Croce, Daniel Von Hoff, Cory Grand
  • Protein kinase inhibitors
    Publication number: 20050227992
    Abstract: Protein kinase inhibitors are disclosed having utility in the treatment of protein kinase-mediated diseases and conditions, such as cancer. The compounds of this invention have the following structure: including steroisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein A is a ring moiety selected from: and wherein R1, R2, R3, X, Z, L1, Cycl1, L2 and Cycl2 are as defined herein. Also disclosed are compositions containing a compound of this invention, as well as methods relating to the use thereof.
    Type: Application
    Filed: October 14, 2004
    Publication date: October 13, 2005
    Applicants: Arizona Board of Regents on behalf of The University of Arizona, Montigen Pharmaceuticals, Inc.
    Inventors: Laurence Hurley, Daruka Mahadevan, Haiyong Han, David Bearss, Hariprasad Vankayalapati, Sridevi Bashyam, Ruben Munoz, Steven Warner, Kimiko Della Croce, Daniel Von Hoff, Cory Grand