Abstract: The present invention relates to the use of (5S)-{[2-(4-carboxyphenyl)ethyl][2-(2-{[3-chloro-4?-(trifluoromethyl)biphenyl-4-yl]methoxy}phenyl)ethyl]-amino}-5,6,7,8-tetrahydroquinoline-2-carboxylic acid of formula (I), prefer-ably in form of one of its salts or solvates or hydrates, preferably (5S)-{[2-(4-carboxyphenyl)ethyl][2-(2-{[3-chloro-4?-(trifluoromethyl)biphenyl-4-yl]methoxy}phenyl)ethyl]-amino}-5,6,7,8-tetrahydroquinoline-2-carboxylic acid in form of monohydrate (I) of formula (I-M-I) or (5S)-{[2-(4-carboxyphenyl)ethyl][2-(2-{[3-chloro-4?-(trifluoromethyl)biphenyl-4-yl]methoxy}phenyl)-ethyl]-amino}-5,6,7,8-tetrahydroquinoline-2-carboxylic acid inform of mono hydrate (II) of formula (I-M-II), in the inhalative treatment of cardiopulmonary and pulmonary disorders, such as pulmonary arterial hypertension (P AH), chronic tromboembolic pulmonary hypertension (CTEPH) and pulmonary hypertension (PH) associated with chronic lung disease (PH group 3) such as pulmonary hypertension in chronic obstructive pulmon

Abstract: Semiconductor module having a first substrate, a second substrate and a spacer distancing the substrates from each other, wherein the spacer is formed by at least one elastic shaped metal body.

Abstract: An NMR method and apparatus uses a magic angle spinning (MAS) system with a MAS turbine having a MAS stator and a MAS rotor. At least two different gases or gas mixtures are fed to the stator through separate gas feeds, a first for the driving of the rotor and another, which is different from the first, for the bearing of the rotor. Respective pressures of the at least two different gases or gas mixtures are regulated separately, and the different gases or gas mixtures are prevented from mixing in the stator by means of a flushing seal through which they at least partially flow out of the stator. Conventional outflow nozzles do not need to be adapted, and the rotor can be operated at a high rotational frequency even at low pressures. The pressures remain stable so that no rotational oscillations occur during the NMR measurement.

Abstract: A water-based adhesive film-forming cover composition including: (i) at least one film forming polymer; (ii) at least one lower crystallinity first polynitroso compound; (iii) at least one higher crystallinity second polynitroso compound; (iv) at least one crosslinking agent; and (v) water as a carrier liquid; a bonding system including a combination of: (a) a water-based primer component; and (b) the above water-based cover component; a process for manufacturing the above bonding system; and a process of manufacturing a bonded article with the above bonding system. A bonded article, having a bonding line made from the above bonding system disposed between metal and rubber substrates, exhibits excellent stability against an aqueous urea-solution at temperatures of up to about 95° C.

Abstract: In particular embodiments, a treadmill may comprise one or more lifting mechanisms configured to lift and lower a treadmill belt (e.g., adjust an angle of the treadmill belt relative to a support surface) by adjusting a height of the front and rear of the treadmill about a pivot point. In particular embodiments, the pivot point may be positioned somewhat centered along a length of the belt. In particular embodiments, a seesaw arrangement may provide a central pivot point, providing a moment arm to the motor while decreasing a moment arm caused by the load (e.g., a runner). In this way, an apparent load on a motor providing incline and decline to the running surface may be reduced.

Abstract: An apparatus for synchronizing frequency to a symbol timing, the apparatus including: a master oscillator to generate a master clock signal; an interpolator to accumulate a frequency error estimate between a symbol timing frequency and the master clock signal; and a frequency controller to transfer a portion of the frequency error estimate to the master oscillator to obtain a lock between the symbol timing and the master clock signal of the master oscillator in a manner that zeros-out the frequency error estimate.

Abstract: A knotter assembly (40) is operable to produce two successive knots (70,68) in a pair of strands of binding material during one full operating cycle of the knotter assembly to secure a formed bale. The knotter assembly includes a billhook (82) configured to perform at least a first full rotation around its rotation axis during formation of a first (70) of the knots and a second full rotation around its rotation axis (228) during formation of a second (68) of the knots. The knotter assembly includes a twine holder (87) and a cutter (94) co-operating with the twine holder (87) for severing the strands during formation of the first one of the successive knots. The knotter assembly (40) includes twine discs having a plurality of notches (200) spaced around the outer circumference. the plurality of notches (200) including a first set of notches having a first shape and a second set of notches having a second shape different than the first shape.

Abstract: A Bernas ion source having a shield is disclosed. The shield is disposed between the distal portion of the filament and the first end of the chamber and serves to confine the plasma to the region between the shield and the second end of the chamber. The shield may be electrically connected to the negative leg of the filament so as to be the most negatively biased component in the chamber. In other embodiments, the shield may be electrically floating. In this embodiment, the shield may self-bias. The shield is typically made of a refractory metal. The use of the shield may reduce back heating of the filament by the plasma and reduce the possibility for thermal runaway. This may allow denser plasmas to be generated within the chamber.

Abstract: This disclosure relates to a medical image viewer for incorporating multi-user collaboration features, such as in-image commenting and workspace sharing. An example method includes receiving a comment location including image coordinates and comment information associated with the comment from a user device. The comment information includes a text body, identify identity information related to the user, and a comment creation date. The example method further includes determining world coordinates based on the image coordinates, and storing the world coordinates and the comment information as a subset of header attributes of the DICOM image file.

Abstract: An apparatus for synchronizing frequency to a symbol timing, the apparatus including: a master oscillator to generate a master clock signal; an interpolator to accumulate a frequency error estimate between a symbol timing frequency and the master clock signal; and a frequency controller to transfer a portion of the frequency error estimate to the master oscillator to obtain a lock between the symbol timing and the master clock signal of the master oscillator in a manner that zeros-out the frequency error estimate.

Abstract: A system for communication of data is provided. The system includes a medical device. A data consuming device is positioned at a first network layer. An edge communication device is positioned at a second network layer. The edge communication device is in communication with the medical device to receive data from the medical device. The edge communication device has a profile. The profile defines a data format for the data and a communication path for transmitting the data between the network layers. A gateway device is configured to route the data from the edge communication device to the data consuming device via the communication path. The edge communication device is also configured to modify the data format to correspond to the data consuming device and to format the data according to the data format.

Abstract: A knotter assembly is used with a baler and configured to form knots in strands of a binding material used to secure a formed bale. The knotter assembly has a rotatably driven knotter disc, a rotary billhook driven by the knotter disc, and a twine disc assembly positioned adjacent the billhook for holding strands of binding material in position for engagement by the billhook. The billhook includes a billhook casting forming a platform, and a billhook tongue connected at a pivot point with the billhook casting. The platform has a first raised lip and a second raised lip forming a channel therebetween configured to receive the billhook tongue so as to firmly grasp the binding material. An upper surface of the first raised lip extends above an upper surface of the second raised lip.

Abstract: A system for communication of data is provided. The system includes a medical device. A data consuming device is positioned at a first network layer. An edge communication device is positioned at a second network layer. The edge communication device is in communication with the medical device to receive data from the medical device. The edge communication device has a profile. The profile defines a data format for the data and a communication path for transmitting the data between the network layers. A gateway device is configured to route the data from the edge communication device to the data consuming device via the communication path. The edge communication device is also configured to modify the data format to correspond to the data consuming device and to format the data according to the data format.

Abstract: The invention relates generally to the field of wound healing. In one embodiment is a method for generating a delayed wound model in an animal, the method comprising contacting a wound with a composition comprising an electrospun scaffold, wherein the scaffold is made from 80% PCL and 20% rat tail collagen and has been soaked in a biofilm conditioned media from Staphylococcus aureus or a small molecular drug FK866.

Abstract: A system and method for beamforming beams including: matching weights T to a distribution of resources for each of the beams based on a traffic variation for each of the beams; calculating, with a signal processor for each of the beams based on the weights T, a power scalar ? and a weighted minimum mean squared error (WMMSE) matrix WWMSE; and transmitting/receiving the beams based on the power scalar ? and the WMMSE matrix WWMSE, where the power scalar ? satisfies a total power constraint of an antenna subsystem.

Abstract: A system and method for beamforming includes providing an antenna including feeds, a coverage area including service areas and data streams for each of the service areas; selecting a cluster of M feeds from the feeds; computing, with a GBBF processor (ground based beam former), M×N weights; generating M feed excitations by distributing the N data streams per the M×N weights; switching an array to transfer a respective one of the M feed excitations to a respective one of the M feeds; and beamforming, with the M feeds of the antenna, N beams. In the method, the N beams are each focused on a respective service area of each of the N data streams, the M×N weights improve the transmitting into the respective service area of each of the N data streams, and at least one of the N beams includes a portion of a plurality of the M feed excitations.

Abstract: A bale binding mechanism is configured to secure a strand of binding material around a bale of severed crop material. The bale binding mechanism includes a chassis, a knotter head assembly, and a captive lock. The knotter head assembly is operable to form at least one knot in the strand of binding material. The knotter head assembly includes a knotter head frame swingably mounted relative to the chassis and rotatable into and out of an operating position where the knotter head assembly can form the at least one knot. The captive lock is shiftably supported by one of the chassis and the knotter head frame. The captive lock is removably engaged with the other one of the chassis and the knotter head frame to secure the knotter head assembly in the operating position, with the captive lock being releasable to permit rotation of the knotter head assembly out of the operating position.

Abstract: A system and method for scheduling a variable stayout distance when beam hopping, the method including providing an illumination area of a satellite and candidate beam centers disposed in the illumination area; measuring a respective scan angle from an antenna boresight to a respective beam center of the candidate beam centers; and determining a reuse factor k for each of the candidate beam centers, based on a proportion of the respective scan angle to a maximum scan angle. Each candidate beam center may be processed sequentially. Prior to adding each candidate beam center to a current beam center set, checking whether a candidate beam center meets the stayout distance criteria from all beam centers already in the beam center set.

Abstract: Computed Tomography (CT) and Magnetic Resonance Imaging (MRI) are commonly used to assess patients with known or suspected pathologies of the lungs and liver. In particular, identification and quantification of possibly malignant regions identified in these high-resolution images is essential for accurate and timely diagnosis. However, careful quantitative assessment of lung and liver lesions is tedious and time consuming. This disclosure describes an automated end-to-end pipeline for accurate lesion detection and segmentation.