Abstract: The present invention relates to the use of (5S)-{[2-(4-carboxyphenyl)ethyl][2-(2-{[3-chloro-4?-(trifluoromethyl)biphenyl-4-yl]methoxy}phenyl)ethyl]-amino}-5,6,7,8-tetrahydroquinoline-2-carboxylic acid of formula (I), prefer-ably in form of one of its salts or solvates or hydrates, preferably (5S)-{[2-(4-carboxyphenyl)ethyl][2-(2-{[3-chloro-4?-(triflu-oromethyl)biphenyl-4-yl]methoxy}phenyl)ethyl]-amino}-5,6,7,8-tetrahydroquinoline-2-carboxylic acid in form of monohydrate (I) of formula (I-M-I) or (5S)-{[2-(4-carboxyphenyl)ethyl] [2-(2-{[3-chloro-4?-(trifluoromethyl)biphenyl-4-yl]methoxy}phenyl)-ethyl]-amino}-5,6,7,8-tetrahydroquinoline-2-carboxylic acid inform of mono hydrate (II) of formula (I-M-II), in the inhalative treatment of car-diopulmonary and pulmonary disorders, such as pulmonary arterial hypertension (P AH), chronic tromboembolic pulmonary hyperten-sion (CTEPH) and pulmonary hypertension (PH) associated with chronic lung disease (PH group 3) such as pulmonary hypertension in chronic obstructive pu

Abstract: Systems and methods for processing bit-interleaved coded modulation (BICM) signals from a BICM transmitter to generate information bit estimates of information in the BICM signals, including a decoder to generate the information bit estimates of the information in the received BICM signals and a symbol a posteriori probability (APP) generator to generate first symbol a posteriori probabilities (APPs) by processing the BICM signals based on Euclidean distances derived from the BICM signals, and further based on symbol probability log-likelihood ratios (SPLLRs) provided to the symbol APP generator by an extrinsic-information-based symbol probability log-likelihood ratio (SPLLR) generator. The SPLLR generator generates the SPLLRs directly from extrinsic information based on updated symbol APPs output from the decoder, without converting the extrinsic information into log-likelihoods (LLs), and the decoder generates the information bit estimates based on the first symbol APPs output from the symbol APP generator.

Abstract: The present invention provides a cell culture for obtaining an epithelial organoid, the cell culture comprising i) epithelial stem cells, or tissue fragments comprising said epithelial stem cells, ii) a basal medium for animal or human cells, iii) a Bone Morphogenetic Protein (BMP) inhibitor, iv) a mitogenic growth factor selected from the group consisting of epidermal growth factor (EGF), transforming growth factor-alpha (TGF-alpha), basic fibroblast growth factor (bFGF), brain-derived neurotrophic factor (BDNF) and keratinocyte growth factor (KGF), v) at least one soluble culture enhancer, wherein said at least one culture enhancer induces correct polarization of the cells in said cell culture within the developing organoid such as a laminin/entactin complex or entactin, and vi) a Wnt agonist if said epithelial stem cells, or tissue fragments comprising said epithelial stem cells are healthy cells, wherein said at least one soluble culture enhancer in said cell culture is a laminin/entactin complex in a con

Abstract: A method for operating a sensor arrangement for detecting a person in an area of use of a sanitary device including: a) activation a first sensor when a second sensor, which differs from the first sensor, detects the presence of at least one person in the vicinity of the sanitary device, wherein the activation establishes a previously completely interrupted power supply to the first sensor and wherein the first sensor is a ToF sensor; b) detection a distance information about the spatial distance between the person and the sanitary device by means of the first sensor, wherein a run time measurement of a signal emitted by the first sensor is performed; c) deactivation of the first sensor when the presence of a person in the vicinity of the sanitary device is no longer detected, wherein the deactivation has a complete interruption of the power supply to the first sensor.

Abstract: A method for categorizing a substrate subject to a semiconductor manufacturing process including multiple operations, the method including: obtaining values of functional indicators derived from data generated during one or more of the multiple operations on the substrate, the functional indicators characterizing at least one operation; applying a decision model including one or more threshold values to the values of the functional indicators to obtain one or more categorical indicators; and assigning a category to the substrate based on the one or more categorical indicators.

Abstract: In particular embodiments, a treadmill may comprise one or more lifting mechanisms configured to lift and lower a treadmill belt (e.g., adjust an angle of the treadmill belt relative to a support surface) by adjusting a height of the front and rear of the treadmill about a pivot point. In particular embodiments, the pivot point may be positioned somewhat centered along a length of the belt. In particular embodiments, a seesaw arrangement may provide a central pivot point, providing a moment arm to the motor while decreasing a moment arm caused by the load (e.g., a runner). In this way, an apparent load on a motor providing incline and decline to the running surface may be reduced.

Abstract: Computed Tomography (CT) and Magnetic Resonance Imaging (MRI) are commonly used to assess patients with known or suspected pathologies of the lungs and liver. In particular, identification and quantification of possibly malignant regions identified in these high-resolution images is essential for accurate and timely diagnosis. However, careful quantitative assessment of lung and liver lesions is tedious and time consuming. This disclosure describes an automated end-to-end pipeline for accurate lesion detection and segmentation.

Abstract: An apparatus for synchronizing frequency to a symbol timing, the apparatus including: a master oscillator to generate a master clock signal; an interpolator to accumulate a frequency error estimate between a symbol timing frequency and the master clock signal; and a frequency controller to transfer a portion of the frequency error estimate to the master oscillator to obtain a lock between the symbol timing and the master clock signal of the master oscillator in a manner that zeros-out the frequency error estimate.

Abstract: A knotter assembly (40) is operable to produce two successive knots (70,68) in a pair of strands of binding material during one full operating cycle of the knotter assembly to secure a formed bale. The knotter assembly includes a billhook (82) configured to perform at least a first full rotation around its rotation axis during formation of a first (70) of the knots and a second full rotation around its rotation axis (228) during formation of a second (68) of the knots. The knotter assembly includes a twine holder (87) and a cutter (94) co-operating with the twine holder (87) for severing the strands during formation of the first one of the successive knots. The knotter assembly (40) includes twine discs having a plurality of notches (200) spaced around the outer circumference. the plurality of notches (200) including a first set of notches having a first shape and a second set of notches having a second shape different than the first shape.

Abstract: This disclosure relates to a medical image viewer for incorporating multi-user collaboration features, such as in-image commenting and workspace sharing. An example method includes receiving a comment location including image coordinates and comment information associated with the comment from a user device. The comment information includes a text body, identify identity information related to the user, and a comment creation date. The example method further includes determining world coordinates based on the image coordinates, and storing the world coordinates and the comment information as a subset of header attributes of the DICOM image file.

Abstract: An apparatus for synchronizing frequency to a symbol timing, the apparatus including: a master oscillator to generate a master clock signal; an interpolator to accumulate a frequency error estimate between a symbol timing frequency and the master clock signal; and a frequency controller to transfer a portion of the frequency error estimate to the master oscillator to obtain a lock between the symbol timing and the master clock signal of the master oscillator in a manner that zeros-out the frequency error estimate.

Abstract: A system for communication of data is provided. The system includes a medical device. A data consuming device is positioned at a first network layer. An edge communication device is positioned at a second network layer. The edge communication device is in communication with the medical device to receive data from the medical device. The edge communication device has a profile. The profile defines a data format for the data and a communication path for transmitting the data between the network layers. A gateway device is configured to route the data from the edge communication device to the data consuming device via the communication path. The edge communication device is also configured to modify the data format to correspond to the data consuming device and to format the data according to the data format.

Abstract: A knotter assembly is used with a baler and configured to form knots in strands of a binding material used to secure a formed bale. The knotter assembly has a rotatably driven knotter disc, a rotary billhook driven by the knotter disc, and a twine disc assembly positioned adjacent the billhook for holding strands of binding material in position for engagement by the billhook. The billhook includes a billhook casting forming a platform, and a billhook tongue connected at a pivot point with the billhook casting. The platform has a first raised lip and a second raised lip forming a channel therebetween configured to receive the billhook tongue so as to firmly grasp the binding material. An upper surface of the first raised lip extends above an upper surface of the second raised lip.

Abstract: A system for communication of data is provided. The system includes a medical device. A data consuming device is positioned at a first network layer. An edge communication device is positioned at a second network layer. The edge communication device is in communication with the medical device to receive data from the medical device. The edge communication device has a profile. The profile defines a data format for the data and a communication path for transmitting the data between the network layers. A gateway device is configured to route the data from the edge communication device to the data consuming device via the communication path. The edge communication device is also configured to modify the data format to correspond to the data consuming device and to format the data according to the data format.

Abstract: The invention relates generally to the field of wound healing. In one embodiment is a method for generating a delayed wound model in an animal, the method comprising contacting a wound with a composition comprising an electrospun scaffold, wherein the scaffold is made from 80% PCL and 20% rat tail collagen and has been soaked in a biofilm conditioned media from Staphylococcus aureus or a small molecular drug FK866.

Abstract: A system and method for beamforming beams including: matching weights T to a distribution of resources for each of the beams based on a traffic variation for each of the beams; calculating, with a signal processor for each of the beams based on the weights T, a power scalar ? and a weighted minimum mean squared error (WMMSE) matrix WWMSE; and transmitting/receiving the beams based on the power scalar ? and the WMMSE matrix WWMSE, where the power scalar ? satisfies a total power constraint of an antenna subsystem.

Abstract: A system and method for beamforming includes providing an antenna including feeds, a coverage area including service areas and data streams for each of the service areas; selecting a cluster of M feeds from the feeds; computing, with a GBBF processor (ground based beam former), M×N weights; generating M feed excitations by distributing the N data streams per the M×N weights; switching an array to transfer a respective one of the M feed excitations to a respective one of the M feeds; and beamforming, with the M feeds of the antenna, N beams. In the method, the N beams are each focused on a respective service area of each of the N data streams, the M×N weights improve the transmitting into the respective service area of each of the N data streams, and at least one of the N beams includes a portion of a plurality of the M feed excitations.

Abstract: A bale binding mechanism is configured to secure a strand of binding material around a bale of severed crop material. The bale binding mechanism includes a chassis, a knotter head assembly, and a captive lock. The knotter head assembly is operable to form at least one knot in the strand of binding material. The knotter head assembly includes a knotter head frame swingably mounted relative to the chassis and rotatable into and out of an operating position where the knotter head assembly can form the at least one knot. The captive lock is shiftably supported by one of the chassis and the knotter head frame. The captive lock is removably engaged with the other one of the chassis and the knotter head frame to secure the knotter head assembly in the operating position, with the captive lock being releasable to permit rotation of the knotter head assembly out of the operating position.

Abstract: A system and method for scheduling a variable stayout distance when beam hopping, the method including providing an illumination area of a satellite and candidate beam centers disposed in the illumination area; measuring a respective scan angle from an antenna boresight to a respective beam center of the candidate beam centers; and determining a reuse factor k for each of the candidate beam centers, based on a proportion of the respective scan angle to a maximum scan angle. Each candidate beam center may be processed sequentially. Prior to adding each candidate beam center to a current beam center set, checking whether a candidate beam center meets the stayout distance criteria from all beam centers already in the beam center set.

Abstract: Computed Tomography (CT) and Magnetic Resonance Imaging (MRI) are commonly used to assess patients with known or suspected pathologies of the lungs and liver. In particular, identification and quantification of possibly malignant regions identified in these high-resolution images is essential for accurate and timely diagnosis. However, careful quantitative assessment of lung and liver lesions is tedious and time consuming. This disclosure describes an automated end-to-end pipeline for accurate lesion detection and segmentation.