Patents by Inventor David BEDNARSKI
David BEDNARSKI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11885562Abstract: In a method for separating argon by cryogenic distillation, in which a flow containing argon, oxygen and nitrogen and being more rich in argon than the air is sent to a distillation column, and an argon-rich gas flow is withdrawn at the top of the column, a portion of the argon-rich gas flow is mixed with beads to form a gas mixture containing beads, the beads being capable of adsorbing oxygen in the presence of argon at the column operating temperatures; the portion of the argon-rich gas flow mixed with the beads is condensed and then sent to the top of the column; and a bottom liquid containing beads is withdrawn from the column and treated to remove the beads, the beads removed being regenerated to remove the adsorbed oxygen and being again mixed with the argon-rich gas flow.Type: GrantFiled: March 3, 2021Date of Patent: January 30, 2024Assignee: L'Air Liquide, Société Anonyme pour l'Etude et l'Exploitation des Procédés Georges ClaudeInventors: Nicolas Kofman, David Bednarski, Bernard Saulnier, Guillaume Cardon, Mikael Wattiau
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Publication number: 20220170701Abstract: A direct heat exchange and material transfer apparatus having a plurality of columns, a single stack of at least two solid metal plates of rectangular section, the plates being substantially all of the same shape and dimensions and parallel to a determined direction, each plate being separated from the adjacent plate, at least in a first direct heat exchange and material transfer zone of the apparatus, by a group of hollow metal columns that are aligned and have a section which is polygonal and has at least two parallel surfaces, the channels being parallel to the determined direction and contiguous with one another, the columns of each group each being in contact with the two metal plates on either side of the group, at least some of the columns of a group containing a material and heat exchange means.Type: ApplicationFiled: February 25, 2020Publication date: June 2, 2022Inventors: Eric MASLIAH, Camille MARIE, Ludovic AMANT, Patrick LE BOT, David FRIMAT, David BEDNARSKI, Jean-Pierre TRANIER
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Publication number: 20210310730Abstract: A unit for producing argon by cryogenic distillation, suitable for connection to a double air separation column consisting of first and second columns interconnected thermally, comprises an argon separation column surmounted with a top condenser and a denitrogenation column, means for withdrawing an argon-rich and nitrogen-depleted product (LAR) at the bottom of the denitrogenation column, means for connecting the top of the argon separation column to the denitrogenation column, means for sending a top gas from the argon separation column to the atmosphere, means for withdrawing a nitrogen-rich fluid from the top of the denitrogenation column, an analyser for measuring the nitrogen content at the top of the argon separation column, and means for opening and closing the means for connecting the top of the argon separation column to the denitrogenation column depending on the nitrogen content detected by the analyser.Type: ApplicationFiled: March 24, 2021Publication date: October 7, 2021Applicant: L'Air Liquide, Societe Anonyme pour l'Etude et l?Exploitation des Procedes Georges ClaudeInventors: Antonio TRUEBA, David BEDNARSKI, Bernard SAULNIER
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Publication number: 20210278131Abstract: In a method for separating argon by cryogenic distillation, in which a flow containing argon, oxygen and nitrogen and being more rich in argon than the air is sent to a distillation column, and an argon-rich gas flow is withdrawn at the top of the column, a portion of the argon-rich gas flow is mixed with beads to form a gas mixture containing beads, the beads being capable of adsorbing oxygen in the presence of argon at the column operating temperatures; the portion of the argon-rich gas flow mixed with the beads is condensed and then sent to the top of the column; and a bottom liquid containing beads is withdrawn from the column and treated to remove the beads, the beads removed being regenerated to remove the adsorbed oxygen and being again mixed with the argon-rich gas flow.Type: ApplicationFiled: March 3, 2021Publication date: September 9, 2021Inventors: Nicolas KOFMAN, David BEDNARSKI, Bernard SAULNIER, Guillaume CARDON, Mikael WATTIAU
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Publication number: 20100111840Abstract: Stabilized lipid construct comprising a liposome or polymerized vesicle, a targeting entity, a therapeutic entity, and a stabilizing entity are provided, as well as methods for their preparation and use.Type: ApplicationFiled: June 4, 2009Publication date: May 6, 2010Inventors: Mark David BEDNARSKI, Neal Edward DeChene, John S. Pease, Charles Aaron Wartchow, Karen J. Brunke
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Publication number: 20040253184Abstract: Polymerized liposome particles which are linked to a targeting agent and may also be linked to a contrast enhancement agent and/or linked to or encapsulating a treatment agent. The targeting imaging enhancement polymerized liposome particles interact with biological targets holding the image enhancement agent to specific sites providing in vitro and in vivo study by magnetic resonance, radioactive, x-ray or optical imaging of the expression of molecules in cells and tissues during disease and pathology. Targeting polymerized liposomes may be linked to or encapsulate a treatment agent, such as, proteins, drugs or hormones for directed delivery to specific biological sites for treatment.Type: ApplicationFiled: May 27, 2003Publication date: December 16, 2004Applicant: Targesome, Inc.Inventors: King Chuen Li, Mark David Bednarski, Richard Wood Storrs, Henry Y. Li, Francois Daniel Tropper, Curtis Kang Hoon Song, Dorothy Anna Sipkins, Jeremy Kenji Kuniyoshi
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Publication number: 20040223911Abstract: Stabilized lipid construct comprising a liposome or polymerized vesicle, a targeting entity, a therapeutic entity, and a stabilizing entity are provided, as well as methods for their preparation and use.Type: ApplicationFiled: June 8, 2004Publication date: November 11, 2004Inventors: Mark David Bednarski, Neal Edward DeChene, John S. Pease, Charles Aaron Wartchow, Karen J. Brunke
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Publication number: 20030133972Abstract: Targeted macromolecules comprising a linking carrier and more than one targeting entity are provided, as well as methods for their preparation and use.Type: ApplicationFiled: May 30, 2002Publication date: July 17, 2003Applicant: TARGESOME, INC.Inventors: S. Narasimhan Danthi, Mark David Bednarski, Charles Aaron Wartchow, Hoyul Steven Choi
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Publication number: 20030129223Abstract: Targeted therapeutic agents, comprising a linking carrier, a therapeutic entity associated with the linking carrier, and at least one targeting entity are provided, as well as methods for their preparation and use.Type: ApplicationFiled: May 30, 2002Publication date: July 10, 2003Applicant: TARGESOME, INC.Inventors: Charles Aaron Wartchow, Neal Edward DeChene, John S. Pease, Zhimin Shen, Julie Trulson, Mark David Bednarski, S. Narasimhan Danthi, Michael Zhang, Hoyul Steven Choi
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Patent number: 6569451Abstract: Polymerized liposome particles which are linked to a targeting agent and may also be linked to a contrast enhancement agent and/or linked to or encapsulating a treatment agent. The targeting imaging enhancement polymerized liposome particles interact with biological targets holding the image enhancement agent to specific sites providing in vitro and in vivo study by magnetic resonance, radioactive, x-ray or optical imaging of the expression of molecules in cells and tissues during disease and pathology. Targeting polymerized liposomes may be linked to or encapsulate a treatment agent, such as, proteins, drugs or hormones for directed delivery to specific biological sites for treatment.Type: GrantFiled: February 26, 2002Date of Patent: May 27, 2003Assignee: Targesome, Inc.Inventors: King Chuen Li, Mark David Bednarski, Richard Wood Storrs, Henry Y. Li, Francois Daniel Tropper, Curtis Kang Hoon Song, Dorothy Anna Sipkins, Jeremy Kenji Kuniyoshi
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Publication number: 20020197210Abstract: Stabilized lipid construct comprising a liposome or polymerized vesicle, a targeting entity, a therapeutic entity, and a stabilizing entity are provided, as well as methods for their preparation and use.Type: ApplicationFiled: March 8, 2002Publication date: December 26, 2002Inventors: Mark David Bednarski, Neal Edward DeChene, John S. Pease, Charles Aaron Wartchow, Karen J. Brunke
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Publication number: 20020146371Abstract: In vivo imaging of disease associated tissues, including tumors and other malignant growths, infection and inflammation, is used in the discovery, screening and development of therapeutic and/or diagnostic molecular targets for intervention in the treatment of the diseases involved. In vivo imaging is used to detect spatial and temporal variations in the imaging features of disease associated tissues. The physical regions of the tissue that correlate with imaging features are then assessed for patterns of gene expression. The corresponding genes or gene products that are upregulated in the regions of interest are useful as therapeutic and imaging targets, with enhanced spatial and/or temporal specificity.Type: ApplicationFiled: October 18, 2001Publication date: October 10, 2002Inventors: King Chuen Li, Mark David Bednarski
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Publication number: 20020071843Abstract: Therapeutic and imaging agents which are comprised of a targeting entity, a therapeutic or treatment entity and a linking carrier are provided. The linking carrier imparts additional advantages to the therapeutic agents, which are not provided by conventional linking methods. Preferred agents of the present invention comprise a lipid construct, vesicle, liposome, or polymerized liposome. In some cases, the therapeutic or treatment entity is a radioisotope, chemotherapeutic agent, prodrug, toxin, or gene encoding a protein that exhibits cell toxicity. Preferably, the agent is further comprised of a stabilizing entity that imparts additional advantages to the therapeutic or imaging agent.Type: ApplicationFiled: October 11, 2001Publication date: June 13, 2002Inventors: King Chuen Li, Mark David Bednarski, Charles A. Wartchow, John S. Pease, Neal E. DeChene, Julie Trulson, Zhi Min Shen
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Patent number: 6350466Abstract: Polymerized liposome particles which are linked to a targeting agent and may also be linked to a contrast enhancement agent and/or linked to or encapsulating a treatment agent. The targeting imaging enhancement polymerized liposome particles interact with biological targets holding the image enhancement agent to specific sites providing in vitro and in vivo study by magnetic resonance, radioactive, x-ray or optical imaging of the expression of molecules in cells and tissues during disease and pathology. Targeting polymerized liposomes may be linked to or encapsulate a treatment agent, such as, proteins, drugs or hormones for directed delivery to specific biological sites for treatment.Type: GrantFiled: August 29, 2000Date of Patent: February 26, 2002Assignee: Targesome, Inc.Inventors: King Chuen Li, Mark David Bednarski, Richard Wood Storrs, Henry Y. Li, Francois Daniel Tropper, Curtis Kang Hoon Song, Dorothy Anna Sipkins, Jeremy Kenji Kuniyoshi
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Patent number: 6132764Abstract: Polymerized liposome particles which are linked to a targeting agent and may also be linked to a contrast enhancement agent and/or linked to or encapsulating a treatment agent. The targeting imaging enhancement polymerized liposome particles interact with biological targets holding the image enhancement agent to specific sites providing in vitro and in vivo study by magnetic resonance, radioactive, x-ray or optical imaging of the expression of molecules in cells and tissues during disease and pathology. Targeting polymerized liposomes may be linked to or encapsulate a treatment agent, such as, proteins, drugs or hormones for directed delivery to specific biological sites for treatment.Type: GrantFiled: April 8, 1996Date of Patent: October 17, 2000Assignee: Targesome, Inc.Inventors: King Chuen Li, Mark David Bednarski, Richard Wood Storrs, Henry Y. Li, Francois Daniel Tropper, Curtis Kang Hoon Song, Dorothy Anna Sipkins, Jeremy Kenji Kuniyoshi
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Patent number: 6090408Abstract: Polymerized liposome particles which are linked to a targeting agent and may also be linked to a contrast enhancement agent and/or linked to or encapsulating a treatment agent. The targeting imaging enhancement polymerized liposome particles interact with biological targets holding the image enhancement agent to specific sites providing in vitro and in vivo study by magnetic resonance, radioactive, x-ray or optical imaging of the expression of molecules in cells and tissues during disease and pathology. Targeting polymerized liposomes may be linked to or encapsulate a treatment agent, such as, proteins, drugs or hormones for directed delivery to specific biological sites for treatment.Type: GrantFiled: July 27, 1998Date of Patent: July 18, 2000Assignee: Targesome, Inc.Inventors: King Chuen Li, Mark David Bednarski, Richard Wood Storrs, Henry Y. Li, Francois Daniel Tropper, Curtis Kang Hoon Song, Dorothy Anna Sipkins, Jeremy Kenji Kuniyoshi