Abstract: A scroll pump includes an inlet and an outlet, a fixed scroll and an orbiting scroll intermeshed with each other, wherein the fixed scroll and orbiting scroll define a space therebetween. The scroll pump further includes a biasing apparatus configured to bias the orbiting scroll against the fixed scroll, a fluid recirculation channel which extends from the space to the inlet through either the fixed scroll or the orbiting scroll, and a fluid recirculation valve disposed in the fluid recirculation channel. The fluid recirculation valve is configured to permit flow of fluid from the space to the inlet through the fluid recirculation channel or to block flow of fluid through the fluid recirculation channel. The fluid recirculation valve is configured to switch from a closed state to an open state when a pressure differential across the fluid recirculation valve is equal to or exceeds a certain threshold value.

Abstract: The present disclosure is concerned with substituted uracil compounds, pharmaceutical compositions comprising the compounds, and methods of treating disorders associated with the presence of a premature termination codon such as, for example, cystic fibrosis, Duchenne muscular dystrophy, aniridia, Becker muscular dystrophy, spinal muscular atrophy, Hurler syndrome, hemophilia, epidermolysis bullosa (e.g., dystrophic (DEB) form, junctional (JEB) form), Usher syndrome, and cancer, using the compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: A heat exchanger for changing a temperature of a pumped gas flow and a pump comprising the heat exchanger is disclosed. The heat exchanger comprises: at least one tube configured to contain a flow of fluid; said at least one tube being at least partially embedded within a block of material; wherein said heat exchanger comprises mounting means configured to mount said heat exchanger adjacent to a gas port of a pump such that a least a portion of said heat exchanger extends into a path for gas flow flowing through said gas port; wherein the mounting means comprises a flange, the flange being configured to connect with the gas port of the pump, the block being mounted to the flange such that the block extends towards the rotor of the pump when the flange is connected with the gas port of the pump.

Abstract: A multi-stage vacuum pump comprising a stator defining multiple pumping chambers is discussed. The stator comprises a plurality of transfer channels for providing a fluid passage from an outlet port of one of the plurality of pumping chambers to an inlet port of a subsequent pumping chamber. Some of the transfer channels comprise two side channel sections on opposing sides of the stator. One of the transfer channels comprises a single side channel section on one side of the stator. The vacuum pump further comprises a gas ballast inlet channel arranged on an other side of the stator to the one side of the stator.

Abstract: A multi-stage vacuum pump comprising a stator defining multiple pumping chambers is discussed. The stator comprises a plurality of transfer channels for providing a fluid passage from an outlet port of one of the plurality of pumping chambers to an inlet port of a subsequent pumping chamber. Some of the transfer channels comprise two side channel sections on opposing sides of the stator. One of the transfer channels comprises a single side channel section on one side of the stator. The vacuum pump further comprises a gas ballast inlet channel arranged on an other side of the stator to the one side of the stator.

Abstract: The invention provides a scroll pump comprising an orbiting scroll and a fixed scroll, wherein the orbital axis of the orbiting scroll is movable in a radial direction relative to the fixed scroll while the orbiting scroll is orbiting about its orbital axis, or wherein the fixed scroll is movable relative to the orbiting scroll in a radial direction while the orbiting scroll is orbiting about its orbital axis.

Abstract: The invention provides a crank sleeve for a scroll pump. The crank sleeve has a longitudinal axis and is configured to provide a radially extending crank offset for imparting an orbital path on an orbital scroll of the scroll pump. The crank sleeve further comprises an integrally formed counterbalance for reducing pump vibration extending radially in a direction substantially opposite to the crank offset.

Abstract: A pump includes a first housing part defining a first portion of a bore extending within the first housing part and shaped to receive a rotor; and a second housing part defining a second portion of the bore extending within the second housing part and shaped to receive the rotor. The first housing part has a first face abutable against an opposing second face of the second housing part to position the first portion of the bore with the second portion of the bore to receive the rotor. The first portion of the bore has a first circular cross-section portion centered along the first face and the second portion of the bore having a second circular cross-section portion centered, within the second housing part, at a distance from the second face.

Abstract: A heat exchanger for changing a temperature of a pumped gas flow and a pump comprising the heat exchanger is disclosed. The heat exchanger comprises: at least one tube configured to contain a flow of fluid; said at least one tube being at least partially embedded within a block of material; wherein said heat exchanger comprises mounting means configured to mount said heat exchanger adjacent to a gas port of a pump such that a least a portion of said heat exchanger extends into a path for gas flow flowing through said gas port; wherein the mounting means comprises a flange, the flange being configured to connect with the gas port of the pump, the block being mounted to the flange such that the block extends towards the rotor of the pump when the flange is connected with the gas port of the pump.

Abstract: A pump includes a first housing part defining a first portion of a bore extending within the first housing part and shaped to receive a rotor; and a second housing part defining a second portion of the bore extending within the second housing part and shaped to receive the rotor. The first housing part has a first face abutable against an opposing second face of the second housing part to position the first portion of the bore with the second portion of the bore to receive the rotor. The first portion of the bore has a first circular cross-section portion centered along the first face and the second portion of the bore having a second circular cross-section portion centered, within the second housing part, at a distance from the second face.

Abstract: The present invention relates to a pump (10) comprising a shaft (15) supported for rotation by a bearing (38) carried by a bearing carrier (48), said bearing carrier having a generally outer radial portion (52) which is fixed relative to a pump housing (12) and a generally inner radial portion (54) which is fixed relative to the bearing, wherein the carrier is stiff in a radial direction between said inner and outer portions and flexible in an axial direction for restraining radial movement of the bearing and allowing axial movement.

Abstract: The present invention relates to a pump (10) comprising a shaft (15) supported for rotation by a bearing (38) carried by a bearing carrier (48), said bearing carrier having a generally outer radial portion (52) which is fixed relative to a pump housing (12) and a generally inner radial portion (54) which is fixed relative to the bearing, wherein the carrier is stiff in a radial direction between said inner and outer portions and flexible in an axial direction for restraining radial movement of the bearing and allowing axial movement.

Abstract: The present invention provides a method of treating lysosomal storage diseases such as Hurler syndrome and Batten disease in individuals in need of such treatment, comprising the step of administering to said individuals a therapeutically effective dose of an aminoglycoside. In addition, this method may further comprise treating the individual with enzyme replacement therapy. Furthermore, the present invention provides method of pharmacologically suppressing premature stop mutations in an individual with these lysosomal storage diseases, comprising the step of administering to said individual a pharmacologically effective dose of an aminoglycoside.

Abstract: The present invention provides a method of treating lysosomal storage diseases such as Hurler syndrome and Batten disease in individuals in need of such treatment, comprising the step of administering to said individuals a therapeutically effective dose of an aminoglycoside. In addition, this method may further comprise treating the individual with enzyme replacement therapy. Furthermore, the present invention provides method of pharmacologically suppressing premature stop mutations in an individual with these lysosomal storage diseases, comprising the step of administering to said individual a pharmacologically effective dose of an aminoglycoside.