Abstract: The present invention is related to compounds of structure (F) as mitogen-activated protein kinase (MEK) inhibitors. (I) The variables are described herein.

Abstract: The present invention is related to compounds of structure (I) as mitogen-activated protein kinase (MEK) inhibitors. The variables are described herein.

Abstract: The present invention is related to compounds of structure (I) as mitogen-activated protein kinase (MEK) and/or ERK inhibitors. (Formula (I)). The variables are described herein.

Abstract: Disclosed are p53 modulators represented by the following structural formula I: The variables in structural formula I are described herein. Also disclosed are method of treating cancer in a subject with the disclosed p53 modulators, particularly cancers with dysfunctional p53.

Abstract: The techniques disclosed herein provide an enhanced single sign-on flow for secure computing resources, such as a virtual machine or hosted applications. In some configurations, the techniques process different types of security data, e.g., credentials, tokens, certificates, and reference objects at specific computing entities of a system to provide a single sign-on flow for providing access to secure computing resources from a client computing device. In one illustrative example, a select type of security data, such as a certificate, is generated from a token and a claim at a particular computing resource, such as an agent operating on a virtual machine. In another example, a signed version of the certificate can be stored and verified at the virtual machine. By generating certificates at such particular computing resources, the computing resource can verify a person's credentials using a secure single sign-on flow without requiring the person to provide credentials multiple times.

Abstract: The techniques disclosed herein provide an enhanced single sign-on flow for secure computing resources, such as a virtual machine or hosted applications. In some configurations, the techniques process different types of security data, e.g., credentials, tokens, certificates, and reference objects at specific computing entities of a system to provide a single sign-on flow for providing access to secure computing resources from a client computing device. In one illustrative example, a select type of security data, such as a certificate, is generated from a token and a claim at a particular computing resource, such as an agent operating on a virtual machine. In another example, a signed version of the certificate can be stored and verified at the virtual machine. By generating certificates at such particular computing resources, the computing resource can verify a person's credentials using a secure single sign-on flow without requiring the person to provide credentials multiple times.

Abstract: A system for controlling energy usage in a server having a processor, where the system includes a memory for storing energy cost information, and a controller for determining a transaction rate for the processor. The controller is also for determining a cumulative of energy expended by the server based on the determined transaction rate for each of a number of available power level states (P-states) for operation of the processor, and for selecting one of the available P-states for operation of the processor based on the determined cumulative energy expended and the stored energy cost information.

Abstract: A system for controlling energy usage in a server having a processor, where the system includes a memory for storing energy cost information, and a controller for determining a transaction rate for the processor. The controller is also for determining a cumulative of energy expended by the server based on the determined transaction rate for each of a number of available power level states (P-states) for operation of the processor, and for selecting one of the available P-states for operation of the processor based on the determined cumulative energy expended and the stored energy cost information.

Abstract: A system for controlling energy usage in a server having a processor, where the system includes a memory for storing energy cost information, and a controller for determining a transaction rate for the processor. The controller is also for determining a cumulative of energy expended by the server based on the determined transaction rate for each of a number of available power level states (P-states) for operation of the processor, and for selecting one of the available P-states for operation of the processor based on the determined cumulative energy expended and the stored energy cost information.

Abstract: An integrated combat resource management device is in the form of a smartphone with a display screen and user input device. The smartphone has a set of integrated applications stored therein which when executed provide an interactive display offering dynamic real-time situational awareness information to the user. Configuration files contain user-specific profiles. A launcher application offers access control and the management of several user profiles on the same smartphone such that upon successful login the appropriate user-specific profile is applied.

Abstract: The disclosed embodiments provide a system that analyzes telemetry data from a computer system. During operation, the system obtains the telemetry data as a set of telemetric signals using a set of sensors in the computer system. Next, the system analyzes the telemetry data to estimate a value of a parameter associated with the computer system, wherein the parameter is at least one of a power utilization and a temperature. Finally, the system controls a subsequent value of the parameter by modulating a virtual duty cycle of a processor in the computer system based on the estimated value.

Abstract: The disclosure provides a method and corresponding system for personalizing and disbursing content material in an automated fashion based on differing characteristics or profiles of the recipients. The system includes a database of potential recipients with key characteristics such as location data, revenue, product ownership, customer status, tenure with the company/organization, payment status, credit rating, whether they have recently responded to other material, and the like. Dissemination media include email communications, collaterals, brochures, textual materials, image and video information, and any similar media, where the contents of the communication material is customized based on the key characteristics profiles of the recipients and driven by a set of business rules that can be adapted to fit various scenarios.

Abstract: A rule-based method and apparatus for evaluating the cost of operating a network infrastructure are disclosed. For example, the method receives a request to evaluate the cost of operating a network infrastructure in a form of one or more rules, e.g., in a natural language format. The one or more rules are translated into at least one cost model. The method then applies the at least one cost model to determine the cost of operating the network infrastructure.

Abstract: The disclosed embodiments provide a system that analyzes telemetry data from a computer system. During operation, the system obtains the telemetry data as a set of telemetric signals using a set of sensors in the computer system. Next, the system analyzes the telemetry data to estimate a value of a parameter associated with the computer system, wherein the parameter is at least one of a power utilization and a temperature. Finally, the system controls a subsequent value of the parameter by modulating a virtual duty cycle of a processor in the computer system based on the estimated value.

Abstract: A system and method for generating a map includes a database for storing a list of recipients and characteristics associated with each recipient in the list of recipients. The method and system also includes a control module for receiving a characteristic associated with at least one recipient in the list of recipients. The method and system also includes a rule engine for generating a map based at least in part on the characteristic associated with the at least one recipient using programmable rules.

Abstract: A system for controlling energy usage in a server having a processor, where the system includes a memory for storing energy cost information, and a controller for determining a transaction rate for the processor. The controller is also for determining a cumulative of energy expended by the server based on the determined transaction rate for each of a number of available power level states (P-states) for operation of the processor, and for selecting one of the available P-states for operation of the processor based on the determined cumulative energy expended and the stored energy cost information.

Abstract: A method and apparatus for determining a bandwidth requirement for a network are disclosed. For example, the method gathers data for one or more types of traffic, and determines an optimal traffic model for each of the one or more types of traffic in accordance with the data and one or more traffic model adaptation rules for each of the one or more types of traffic. The method then determines a demand forecast for each of the one or more types of traffic by applying the optimal traffic model for each of the one or more types of traffic, and determines a bandwidth requirement for the one or more types of traffic in accordance with the demand forecast.

Abstract: A method for providing network access privacy by classifying filter parameters of a group of users who are accessing one or more network destinations. The system includes a means for collecting information from both users, and about network destinations, generating suggestions for a user regarding filter parameters, and filtering network communications of users going to network destinations. In operation, users who are accessing network destinations are prompted to choose from a selection of filter parameters. The information provided by these users is then analyzed and used to generate suggested filter parameters for other users. As users provide more information to the system about various network destinations the system is able to provide more information to users about more network destinations and thus generate more accurate filter parameter suggestions. After a user selects their filter parameters the system filters a range of information coming from the user and going out to the network destination.

Abstract: A method and an apparatus to automate the process and procedure for long haul service providers to choose the best quote from a pool of quotes or RFP responses as the best supplier in a country or region. The disclosed method and apparatus includes a mathematical framework which determines the characteristics of each supplier option and a method to determine the cost effectiveness of each option. This method and apparatus reduces overhead and improves the evaluation process for choosing optimal access providers for long-haul communication providers.

Abstract: A lighted exit sign equipped with laser guidance capability is provided. The laser lighted guidance indicator includes at least one printed circuit (PC) board and associated circuitry for controlling the beam pattern of at least one Light Emitting Diode (LED) laser via at least one reflection device associated with the at least one LED laser. The evacuee is directed towards the exit by following the converging LED laser lights. The lighted exit sign may also include includes a display area and display microprocessor for controlling the display area. The display area may display alternate emergency messages such as “EXIT” and “SALIDA” or other language equivalents. The PC board, laser LEDs and reflectors are enclosed within a waterproof, shockproof, vibration tolerant, and theft deterrent enclosure.