Abstract: An ischemia detection system in two or more somatic measures, collected simultaneously or near-simultaneously, are provided for direct or computational comparison, in which light from light source A (103A) and source B (103B) is detected by a sensor (155), and a difference-weighted value is determined (167), thereby enhancing the value of the spectroscopic measurements over values taken individually and singly.

Abstract: A device and a method for the screening of in-vivo tumors in a target tissue are provided. The device and method provide a local measure of a risk of tumor presence in the target tissue with high specificity. The local measure may be based upon a non-linear combination of local hemoglobin and tissue oxygen saturation and other tissue characteristics.

Abstract: An implantable ischemia detection system in which a white LED (105) produces a continuous, visible, broadband light illuminating a target site (125). Light backscattered by the target is collected by a sensor (155), allowing for an index of ischemia to be determined, and subsequently transmitted by a sending unit (167). Power is provided by an internal power source (179). The entire implantable device is encapsulated by a biocompatible shell (102) to add long-term safety with regard to implantation.

Abstract: An implantable ischemia detection device in which a broadband light source produces a continuous, visible, broadband light illuminating capillary sites within a well localized target tissue is provided. Light backscattered by the target tissue is collected by a sensor, allowing for an index of ischemia to be determined, and subsequently transmitted by a sending unit. Optionally, the device may be provided with an internal power source, the entire device encapsulated by a biocompatible shell to add long-term safety while implanted at a target tissue site.

Abstract: An improved hybrid connector for rapidly, reliably, and reversibly making mixed optical and electrical connections has a plug (103) with one or more centrally located fiber-containing optical ferrules (108) and one or more peripheral electrical contacts (109), and second, a socket (105) with interior electrical contacts (115) and a fiber-bearing central floating optical connector (225). Insertion and rotation of a shaft (107) of the plug into a bore (201) of the socket connects the respective electrical contacts of the shaft and socket, and nearly-simultaneously couples the respective optical fibers of the plug ferrule and socket connector, thus creating a rapid, reversible, and low-cost hybrid connection optimized for both the electrical and optical requirements of a mixed optical and electrical connection.

Abstract: Methods and compositions for detecting and localizing light originating from a mammal are disclosed. Also disclosed are methods for targeting light emission to selected regions, as well as for tracking entities within the mammal. In addition, animal models for disease states are disclosed, as are methods for localizing and tracking the progression of disease or a pathogen within the animal, and for screening putative therapeutic compounds effective to inhibit the disease or pathogen.

Abstract: Methods and compositions for detecting and localizing light originating from a mammal are disclosed. Also disclosed are methods for targeting light emission to selected regions, as well as for tracking entities within the mammal. In addition, animal models for disease states are disclosed, as are methods for localizing and tracking the progression of disease or a pathogen within the animal, and for screening putative therapeutic compounds effective to inhibit the disease or pathogen.