Patents by Inventor David Benjamin Buckley

David Benjamin Buckley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • In vitro test system to evaluate xenobiotics as immune-modulators of drug transport and metabolism in human hepatocytes
    Patent number: 10648968
    Abstract: A method for evaluating in vitro the effect of a xenobiotic (e.g., a drug) on drug metabolism in hepatocytes. The kit comprises a first culture of hepatocytes, a portion of in vitro xenobiotic-stimulated biological sample, and instructions for incubating the first culture of hepatocytes with the portion of in vitro xenobiotic-stimulated biological sample, and analyzing the activity, expression, or a combination thereof of a biomarker in the hepatocytes to evaluate the effect of the xenobiotic on drug metabolism in the hepatocytes.
    Type: Grant
    Filed: May 18, 2018
    Date of Patent: May 12, 2020
    Assignee: XenoTech, L.L.C.
    Inventors: Maciej Czerwinski, David Benjamin Buckley, Faraz Kazmi
  • IN VITRO TEST SYSTEM TO EVALUATE XENOBIOTICS AS IMMUNE-MODULATORS OF DRUG TRANSPORT AND METABOLISM IN HUMAN HEPATOCYTES
    Publication number: 20180267023
    Abstract: A method for evaluating in vitro the effect of a xenobiotic (e.g., a drug) on drug metabolism in hepatocytes. The kit comprises a first culture of hepatocytes, a portion of in vitro xenobiotic-stimulated biological sample, and instructions for incubating the first culture of hepatocytes with the portion of in vitro xenobiotic-stimulated biological sample, and analyzing the activity, expression, or a combination thereof of a biomarker in the hepatocytes to evaluate the effect of the xenobiotic on drug metabolism in the hepatocytes.
    Type: Application
    Filed: May 18, 2018
    Publication date: September 20, 2018
    Inventors: Maciej Czerwinski, David Benjamin Buckley, Faraz Kazmi
  • In vitro test system to evaluate xenobiotics as immune-modulators of drug transport and metabolism in human hepatocytes
    Patent number: 10001471
    Abstract: A kit and method for evaluating in vitro the effect of a xenobiotic (e.g., a biologic drug) on drug metabolism in hepatocytes. The kit comprises a first culture of hepatocytes, a portion of in vitro xenobiotic-stimulated biological sample, and instructions for incubating the first culture of hepatocytes with the portion of in vitro xenobiotic-stimulated biological sample, and analyzing the activity, expression, or a combination thereof of a biomarker in the hepatocytes to evaluate the effect of the xenobiotic on drug metabolism in the hepatocytes.
    Type: Grant
    Filed: July 31, 2014
    Date of Patent: June 19, 2018
    Assignee: XENOTECH LLC
    Inventors: Maciej Czerwinski, David Benjamin Buckley, Faraz Kazmi
  • IN VITRO TEST SYSTEM TO EVALUATE XENOBIOTICS AS IMMUNE-MODULATORS OF DRUG TRANSPORT AND METABOLISM IN HUMAN HEPATOCYTES
    Publication number: 20140342944
    Abstract: A kit and method for evaluating in vitro the effect of a xenobiotic (e.g., a biologic drug) on drug metabolism in hepatocytes. The kit comprises a first culture of hepatocytes, a portion of in vitro xenobiotic-stimulated biological sample, and instructions for incubating the first culture of hepatocytes with the portion of in vitro xenobiotic-stimulated biological sample, and analyzing the activity, expression, or a combination thereof of a biomarker in the hepatocytes to evaluate the effect of the xenobiotic on drug metabolism in the hepatocytes.
    Type: Application
    Filed: July 31, 2014
    Publication date: November 20, 2014
    Inventors: Maciej Czerwinski, David Benjamin Buckley, Faraz Kazmi
  • In vitro test system to evaluate xenobiotics as immune-modulators of drug transport and metabolism in human hepatocytes
    Patent number: 8846576
    Abstract: A method of evaluating the effect of a xenobiotic on biomarkers, such as drug transporters and drug-metabolizing enzymes in hepatocytes is provided. The method comprises the formation of a xenobiotic-stimulated biological sample, such as whole blood, which contains a plurality of cytokines. A portion of xenobiotic-stimulated biological sample is cultured with hepatocytes. The hepatocytes are then analyzed to evaluate the activity of drug transporters and/or drug-metabolizing enzymes, or other biomarkers to determine the effect of the xenobiotic on drug metabolism in the hepatocytes.
    Type: Grant
    Filed: May 25, 2012
    Date of Patent: September 30, 2014
    Assignee: Xenotech LLC
    Inventors: Maciej Czerwinski, David Benjamin Buckley, Faraz Kazmi
  • IN VITRO TEST SYSTEM TO EVALUATE XENOBIOTICS AS IMMUNE-MODULATORS OF DRUG TRANSPORT AND METABOLISM IN HUMAN HEPATOCYTES
    Publication number: 20120301892
    Abstract: A method of evaluating the effect of a xenobiotic on biomarkers, such as drug transporters and drug-metabolizing enzymes in hepatocytes is provided. The method comprises the formation of a xenobiotic-stimulated biological sample, such as whole blood, which contains a plurality of cytokines. A portion of xenobiotic-stimulated biological sample is cultured with hepatocytes. The hepatocytes are then analyzed to evaluate the activity of drug transporters and/or drug-metabolizing enzymes, or other biomarkers to determine the effect of the xenobiotic on drug metabolism in the hepatocytes.
    Type: Application
    Filed: May 25, 2012
    Publication date: November 29, 2012
    Applicant: XENOTECH LLC
    Inventors: Maciej Czerwinski, David Benjamin Buckley, Faraz Kazmi