Patents by Inventor David Berd
David Berd has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230398206Abstract: The invention relates to a method of eliciting an immune response in a human subject showing no signs or symptoms of an active SARS-CoV-2 infection comprising administering intra-dermally to the human subject an immunogenic composition comprising the Spike protein (S protein) of SARS-CoV-2 or a fragment thereof.Type: ApplicationFiled: October 27, 2021Publication date: December 14, 2023Inventors: David Berd, James Passin
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Publication number: 20230149534Abstract: The disclosure provides an immunogenic composition comprising an haptenized Spike protein (S protein) or fragment thereof from a coronavirus and at least one pharmaceutically acceptable carrier, wherein the coronavirus comprising severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Further disclosed are methods of using the haptenized S proteins from coronavirus or immunizing a subject against coronavirus infection.Type: ApplicationFiled: March 19, 2021Publication date: May 18, 2023Inventors: David Berd, James Passin
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Publication number: 20220047703Abstract: In some embodiments, methods of treating cancer, including metastatic cancers, cancers that are resistant to immune checkpoint inhibitor therapy, and cancers that do not respond to immune checkpoint inhibitor therapy or have acquired resistance to immune checkpoint inhibitor therapy are disclosed.Type: ApplicationFiled: September 24, 2019Publication date: February 17, 2022Inventor: David Berd
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Publication number: 20140113371Abstract: A method of preserving haptenized tumor cells is described. The method employs a freezing medium containing an effective amount of sucrose and human serum albumin in an isotonic buffered saline solution. Cryogenically preserving haptenized cells in such a medium has been found to maintain the integrity of the tumor cells during storage. The haptenized tumor cells also retain cell-associated antigens and haptens, and are as immunogenic, i.e., capable of inducing immunotherapeutic response, as fresh vaccine in a mouse model of metastatic disease. In a specific embodiment, haptenized cells are exposed to a solution of 8% sucrose, 10% human serum albumin in Hank's buffered solution, and then frozen to ?80° C. overnight and then stored in a liquid nitrogen freezer. Methods of storing haptenized tumor cells and compositions are also provided.Type: ApplicationFiled: May 6, 2013Publication date: April 24, 2014Inventors: David Berd, Lorne F. Erdile, Margalit B. Mokyr
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Publication number: 20130309271Abstract: The present invention discloses a method for producing a haptenized vaccine from a tissue biopsy. The method includes obtaining a tissue biopsy, isolating the cells, irradiating the cells, haptenizing the cells, and cryopreserving the cells. The present invention also discloses a method for treating cancer using the vaccines produced by the methods described herein.Type: ApplicationFiled: July 26, 2013Publication date: November 21, 2013Applicant: AVAX TECHNOLOGIES, INC.Inventor: David BERD
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Patent number: 8435784Abstract: A method of preserving haptenized tumor cells is described. The method employs a freezing medium containing an effective amount of sucrose and human serum albumin in an isotonic buffered saline solution. Cryogenically preserving haptenized cells in such a medium has been found to maintain the integrity of the tumor cells during storage. The haptenized tumor cells also retain cell-associated antigens and haptens, and are as immunogenic, i.e., capable of inducing immunotherapeutic response, as fresh vaccine in a mouse model of metastatic disease. In a specific embodiment, haptenized cells are exposed to a solution of 8% sucrose, 10% human serum albumin in Hank's buffered solution, and then frozen to ?80° C. overnight and then stored in a liquid nitrogen freezer. Methods of storing haptenized tumor cells and compositions are also provided.Type: GrantFiled: June 13, 2007Date of Patent: May 7, 2013Inventors: David Berd, Lorne F. Erdile, Margalit B. Mokyr
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Publication number: 20100221290Abstract: This invention relates to compositions comprising multi-haptenized tumor cells and extracts thereof, methods for preparing the compositions, vaccines comprising such multi-haptenized tumor cells, and methods for treating cancer with such vaccines. In a specific embodiment, melanoma and ovarian adenocarcinoma cells are multi-haptenized, wherein the tumor cells are differentially haptenized either with a dinitrophenyl group coupled to s-amino groups, or with a sulfanilic acid group coupled to aromatic side chains of histidine and tyrosine. A method of SA-haptenization is also provided.Type: ApplicationFiled: May 6, 2010Publication date: September 2, 2010Applicant: THOMAS JEFFERSON UNIVERSITYInventor: David Berd
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Publication number: 20100099187Abstract: The present invention discloses a method for producing a haptenized vaccine from a tissue biopsy. The method includes obtaining a tissue biopsy, isolating the cells, irradiating the cells, haptenizing the cells, and cryopreserving the cells. The present invention also discloses a method for treating cancer using the vaccines produced by the methods described herein.Type: ApplicationFiled: December 20, 2009Publication date: April 22, 2010Applicant: AVAX TECHNOLOGIES, INC.Inventor: DAVID BERD
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Patent number: 7585512Abstract: The present invention is directed to a treatment for cancer. Compositions and methods of treating cancer are included in the scope of the present invention. The compositions of the present invention include a composition prepared from tumor cells or tumor cell extracts. The methods of the present invention are directed to treating cancer comprising administering a therapeutically effective amount of a composition comprising tumor cells and/or tumor cell extracts.Type: GrantFiled: February 28, 1994Date of Patent: September 8, 2009Assignee: Thomas Jefferson UniversityInventor: David Berd
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Patent number: 7560103Abstract: The present invention is directed to compositions and methods of treating cancer. The compositions of the present invention include a composition prepared from a tumor cell which is hapten modified and syngeneic to the type of tumor to be treated. The composition has the properties, when administered with an adjuvant to a human suffering from a malignant tumor of the same type as said tumor cell, of eliciting T lymphocytes that infiltrate the tumor of said human, of eliciting an inflammatory immune response against the tumor of said human, and of eliciting a delayed-type hypersensitivity response to the tumor of said human. The methods of the present invention are directed to treating cancer comprising administering a therapeutically effective amount of a composition comprising a tumor cell.Type: GrantFiled: December 19, 2001Date of Patent: July 14, 2009Assignee: Thomas Jefferson UniversityInventor: David Berd
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Publication number: 20080044441Abstract: This invention relates to compositions comprising multi-haptenized tumor cells and extracts thereof, methods for preparing the compositions, vaccines comprising such multi-haptenized tumor cells, and methods for treating cancer with such vaccines. In a specific embodiment, melanoma and ovarian adenocarcinoma cells are multi-haptenized, wherein the tumor cells are differentially haptenized either with a dinitrophenyl group coupled to ?-amino groups, or with a sulfanilic acid group coupled to aromatic side chains of histidine and tyrosine. A method of SA-haptenization is also provided.Type: ApplicationFiled: December 20, 2006Publication date: February 21, 2008Inventor: David Berd
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Patent number: 7297330Abstract: This invention relates to compositions comprising haptenized tumor cells and extracts thereof, methods for preparing the compositions, vaccines comprising such haptenized tumor cells, and methods for treating cancer with such vaccines. In a specific embodiment, melanoma cells are haptenized with a dinitrophenyl group, and used for treatment of melanoma patients having metastatic disease. Preferably, patients are given a first vaccine dose containing haptenized cells to “prime” the immune system. Subsequently, patients are injected with an immunomodulatory compound such as cyclophosphamide. In a preferred embodiment, an appropriate time period after the “priming” vaccine dose, additional vaccine doses containing a mixture of haptenized cells and an adjuvant are administered. The described treatment plan is more effective for eliciting favorable anti-tumor immune responses.Type: GrantFiled: February 1, 2001Date of Patent: November 20, 2007Assignee: Thomas Jefferson UniversityInventor: David Berd
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Publication number: 20070237795Abstract: A method of preserving haptenized tumor cells is described. The method employs a freezing medium containing an effective amount of sucrose and human serum albumin in an isotonic buffered saline solution. Cryogenically preserving haptenized cells in such a medium has been found to maintain the integrity of the tumor cells during storage. The haptenized tumor cells also retain cell-associated antigens and haptens, and are as immunogenic, i.e., capable of inducing immunotherapeutic response, as fresh vaccine in a mouse model of metastatic disease. In a specific embodiment, haptenized cells are exposed to a solution of 8% sucrose, 10% human serum albumin in Hank's buffered solution, and then frozen to ?80° C. overnight and then stored in a liquid nitrogen freezer. Methods of storing haptenized tumor cells and compositions are also provided.Type: ApplicationFiled: June 13, 2007Publication date: October 11, 2007Inventors: David Berd, Lorne Erdile, Margalit Mokyr
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Publication number: 20060240047Abstract: The present invention discloses a method for producing a haptenized vaccine from a tissue biopsy. The method includes obtaining a tissue biopsy, isolating the cells, irradiating the cells, haptenizing the cells, and cryopreserving the cells. The present invention also discloses a method for treating cancer using the vaccines produced by the methods described herein.Type: ApplicationFiled: January 13, 2006Publication date: October 26, 2006Inventor: David Berd
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Publication number: 20050232951Abstract: This invention relates to compositions comprising haptenized tumor cells and extracts thereof, methods for preparing the compositions, vaccines comprising such haptenized tumor cells, and methods for treating cancer with such vaccines. In a specific embodiment, melanoma cells are haptenized with a dinitrophenyl group, and used for treatment of melanoma patients having metastatic disease. Preferably, patients are given a first vaccine dose containing haptenized cells to “prime” the immune system. Subsequently, patients are injected with an immunomodulatory compound such as cyclophosphamide. In a preferred embodiment, an appropriate time period after the “priming” vaccine dose, additional vaccine doses containing a mixture of haptenized cells and an adjuvant are administered. The described treatment plan is more effective for eliciting favorable anti-tumor immune responses.Type: ApplicationFiled: December 17, 2004Publication date: October 20, 2005Inventor: David Berd
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Publication number: 20050233301Abstract: A method of preserving haptenized tumor cells is described. The method employs a freezing medium containing an effective amount of sucrose and human serum albumin in an isotonic buffered saline solution. Cryogenically preserving haptenized cells in such a medium has been found to maintain the integrity of the tumor cells during storage. The haptenized tumor cells also retain cell-associated antigens and haptens, and are as immunogenic, i.e., capable of inducing immunotherapeutic response, as fresh vaccine in a mouse model of metastatic disease. In a specific embodiment, haptenized cells are exposed to a solution of 8% sucrose, 10% human serum albumin in Hank's buffered solution, and then frozen to ?80° C. overnight and then stored in a liquid nitrogen freezer. Methods of storing haptenized tumor cells and compositions are also provided.Type: ApplicationFiled: December 9, 2004Publication date: October 20, 2005Inventors: David Berd, Lorne Erdile, Margalit Mokyr
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Publication number: 20030170756Abstract: A method comprising exposing tumor cells to ethanol has been found to preserve the tumor cells during storage. As compared to control cells, tumor cells are preserved for a longer time, and retain display of antigen. In a specific embodiment, modified or unmodified cells are exposed to a concentration of about 37.5% (v/v) ethanol for a period of about 10 minutes at about 40° C. Methods of storing haptenized tumor cells and vaccine preparations are also provided. It has also been found that tumor cell vaccines which comprise mainly dead or non-Trypan Blue-excluding cells can have retained or even improved antigenicity as compared to live cells. Methods of preparing and using such vaccines are also described.Type: ApplicationFiled: February 3, 2003Publication date: September 11, 2003Applicant: Thomas Jefferson UniversityInventor: David Berd
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Publication number: 20030165518Abstract: This invention relates to compositions comprising multi-haptenized tumor cells and extracts thereof, methods for preparing the compositions, vaccines comprising such multi-haptenized tumor cells, and methods for treating cancer with such vaccines. In a specific embodiment, melanoma and ovarian adenocarcinoma cells are multi-haptenized, wherein the tumor cells are differentially haptenized either with a dinitrophenyl group coupled to &egr;-amino groups, or with a sulfanilic acid group coupled to aromatic side chains of histidine and tyrosine. A method of SA-haptenization is also provided.Type: ApplicationFiled: February 3, 2003Publication date: September 4, 2003Applicant: Thomas Jefferson UniversityInventor: David Berd
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Publication number: 20030086906Abstract: A method of inducing expression of immune active cytokines in tumors in situ is provided wherein a vaccinia virus vector capable of inducing expression of a selected cytokine is generated and injected into a tumor so that cells of the tumor express the selected cytokine. A method of enhancing immunity in a host by administration of a vaccinia virus vector is also provided. Methods of treating cancer by administration of these vaccinia virus vectors are also provided.Type: ApplicationFiled: November 4, 2002Publication date: May 8, 2003Inventors: Michael J. Mastrangelo, Edmund C. Lattime, David Berd, Laurence C. Eisenlohr
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Publication number: 20030068337Abstract: The present invention is directed to compositions containing hapten-modified tumor cells and extracts and methods of treating cancer by administering a therapeutically effective amount of a composition containing a tumor cell or tumor cell extract to a subject in need of such treatment. The tumor cells and extracts of the invention and compositions thereof are capable of eliciting T lymphocytes that have a property of infiltrating a mammalian tumor, eliciting an inflammatory immune response to a mammalian tumor, eliciting a delayed-type hypersensitivity response to a mammalian tumor and/or stimulating T lymphocytes in vitro. The invention also relates to an effective vaccination schedule useful for inducing an antitumor response in a mammalian patient suffering from cancer by inducing at least one of the following: tumor necrosis, tumor regression, tumor inflammation, tumor infiltration by activated T lymphocytes, delayed-type hypersensitivity response, and prolongation of patient survival.Type: ApplicationFiled: September 27, 2002Publication date: April 10, 2003Applicant: Thomas Jefferson UniversityInventor: David Berd