Abstract: The trial planning system of various embodiments herein may include a data warehouse configured to receive data from one or more data sources and interconnected with a modelling system and a forecasting system. Such a modelling system may include a pre-award module and a post-award module, each of which may comprise at least one model configured to generate a predictive trial output pertaining to the bid and planning phase and post-award phase of a clinical trial, respectively, including, without limitation, various metrics related to trial start-up, site activation, and patient recruitment. Such a forecasting system may include a variety of modules configured to enable a user to input various parameters relating to a trial, view and select sites for trial assessment, display various graphics details generated forecasts, and override the predictive trial outputs generated by the modelling system to develop more accurate, detailed, and granular forecasts for a given trial.

Abstract: Nutritive Polypeptides are provided herein. Also provided are various other embodiments including nucleic acids encoding the polypeptides, recombinant microorganisms that make the polypeptides, vectors for expressing the polypeptides, methods of making the polypeptides using recombinant microorganisms, compositions and formulations that comprise the polypeptides, and methods of using the polypeptides, compositions and formulations.

Abstract: Methods for providing one or more guided workflow features with regard to a fluid injector system, may include receiving data associated with the fluid injector system, displaying a first graphical user interface (GUI) screen associated with a guided workflow for operation of the fluid injector system on one or more display devices based on the data associated with one or more components of the fluid injector system, receiving a first user input, displaying a second GUI screen associated with the guided workflow on the one or more display devices based on receiving the first user input, executing a first operation of the fluid injector system, and receiving a second user input, where the second GUI screen provides information that is sequential to the first GUI screen with regard to the guided workflow for operation of the fluid injector system. Systems and computer program products are also disclosed.

Abstract: A fluid path connector assembly for a medical fluid delivery system includes a connector element having a body, a lumen extending through the body, and a pair of flexible legs connected to the body, each of the flexible legs having a flange. The connector assembly further includes a dust cap removably connected to the connector element. The dust cap includes a dust cap body positioned between the flexible legs to enclose the lumen, and an engagement element at a distal end of the dust cap body. The engagement element is in contact with the flanges of the flexible legs to prevent disengagement of the dust cap from the connector element while allowing ready removal of the dust cap by medical personnel. A removable/disconnectable tamper resistant and/or tamper-evident and/or tamper resistant feature connecting the dust cap to the connector element is also disclosed.

Abstract: A state evaluator for use in a media library includes a housing and a first camera that is coupled to the housing. In some embodiments, the state evaluator can also include one or more of a light assembly, an indicator assembly to indicate different conditions associated with the state evaluator, an input assembly, an internal power source, and a power module. The power source can be rechargeable and/or removable. The first camera can capture visible light, infrared light, and/or ultraviolet light images. The light assembly can emit visible light, infrared light, and/or ultraviolet light. The state evaluator can have a high intensity light source and can communicate with a host system. The state evaluator can also include a second camera that can be coupled to the housing.

Abstract: An injector system for delivering a medical fluid, the injector system including an injector configured to receive at least one syringe, the injector comprising at least one piston for releasably engaging and reciprocally driving a plunger or an end wall of the at least one syringe; and a syringe retaining interface comprising one or more retaining elements configured to engage at least a portion of a distal end portion of the at least one syringe to limit movement of the at least one syringe in a distal direction relative to the injector as the medical fluid is delivered from the reservoir via distal movement of the at least one piston.

Abstract: A fluid container having a proximal end having an end wall, a distal end having an open-ended neck, and a sidewall extending between the proximal end and the distal end along a longitudinal axis is described. A localized crystallinity of a polymeric material of the fluid container of at least a first region of the fluid container is greater than a crystallinity of a polymeric material of the fluid container of at least a second region. Examples of fluid containers include medical fluid containers, such as medical bottles and syringes, including rolling diaphragm-type syringes, and commercial beverage containers Articles of manufacturer formed form a polymeric material and having regions with increased localized polymeric crystallinity are also described.

Abstract: A fluid control valve for use in a fluid delivery system for delivering fluid to a patient includes a valve body defining an internal chamber, a first inlet port for receiving a first inlet tube, a second inlet port for receiving a second inlet tube, an outlet port, and a sliding valve member slidably disposed in the internal chamber. The first inlet tube defines a first inlet lumen axially aligned with the internal chamber. The second inlet tube defines a second inlet lumen axially aligned with the internal chamber. The sliding valve member includes a first sealing end and second sealing end. The sliding valve member is positionable in a first operating state, a second operating state, and a third operating state based on a flow differential between the first inlet lumen and the second inlet lumen.

Abstract: Systems and methods for determining accurate addresses for assets are described herein. According to some aspects, a plurality of addresses associated with an asset are compiled from sources such as database systems. For the plurality of address records, scores that correspond to attributes of the address records can be determined. Attributes associated with the address records may include a recency, a source, a date, license plate data, or address type, to name several non-limiting examples. Additionally, a zone of interest for the asset can be determined based on the plurality of address records. The plurality of address records is prioritized based on their distance from the zone of interest and the scores associated with them and, based on the priority, a subset of the plurality of address records is sent to, for example, a service provider.

Abstract: A state evaluator for use in a media library includes a housing and a first camera that is coupled to the housing. In some embodiments, the state evaluator can also include one or more of a light assembly, an indicator assembly to indicate different conditions associated with the state evaluator, an input assembly, an internal power source, and a power module. The power source can be rechargeable and/or removable. The first camera can capture visible light, infrared light, and/or ultraviolet light images. The light assembly can emit visible light, infrared light, and/or ultraviolet light. The state evaluator can have a high intensity light source and can communicate with a host system. The state evaluator can also include a second camera that can be coupled to the housing.

Abstract: A state evaluator for use in a media library includes a housing and a first camera that is coupled to the housing. In some embodiments, the state evaluator can also include one or more of a light assembly, an indicator assembly to indicate different conditions associated with the state evaluator, an input assembly, an internal power source, and a power module. The power source can be rechargeable and/or removable. The first camera can capture visible light, infrared light, and/or ultraviolet light images. The light assembly can emit visible light, infrared light, and/or ultraviolet light. The state evaluator can have a high intensity light source and can communicate with a host system. The state evaluator can also include a second camera that can be coupled to the housing.

Abstract: Probiotic compositions containing non-pathogenic microbial entities, e.g., bacterial entities, are described herein. The probiotic compositions may optionally contain or be used in conjunction with one or more prebiotics. Uses of the probiotic compositions to treat or prevent disorders of the local or systemic microbiome in a subject are also provided.

Abstract: An engagement mechanism associated with a reciprocally movable piston of a fluid injector is configured for releasably engaging an engagement portion at a proximal end of a rolling diaphragm syringe having a flexible sidewall configured for rolling upon itself when acted upon by the piston. The engagement mechanism has a plurality of engagement elements reversibly and pivotally movable about a pivot pin relative to the engagement portion of the syringe between a first position, where the plurality of engagement elements are disengaged from the engagement portion of the syringe, and a second position, where the plurality of engagement elements are pivotally movable about the pivot pin in a radially inward direction to engage with the engagement portion of the syringe. The engagement mechanism further has a drive mechanism for moving the plurality of engagement elements between the first position and the second position.

Abstract: Pharmaceutical compositions containing microbial entities are described herein. The pharmaceutical compositions may optionally contain or be used in conjunction with one or more prebiotics. Uses of the pharmaceutical compositions to treat or prevent disorders of the local or systemic microbiome in a subject are also provided.

Abstract: Pharmaceutical compositions containing microbial entities are described herein. The pharmaceutical compositions may optionally contain or be used in conjunction with one or more prebiotics. Uses of the pharmaceutical compositions to treat or prevent disorders of the local or systemic microbiome in a subject are also provided.

Abstract: An engagement mechanism associated with a reciprocally movable piston of a fluid injector is configured for releasably engaging an engagement portion at a proximal end of a rolling diaphragm syringe having a flexible sidewall configured for rolling upon itself when acted upon by the piston. The engagement mechanism has a plurality of engagement elements reversibly and pivotally movable about a pivot pin relative to the engagement portion of the syringe between a first position, where the plurality of engagement elements are disengaged from the engagement portion of the syringe, and a second position, where the plurality of engagement elements are pivotally movable about the pivot pin in a radially inward direction to engage with the engagement portion of the syringe. The engagement mechanism further has a drive mechanism for moving the plurality of engagement elements between the first position and the second position.

Abstract: Systems and methods for determining accurate addresses for assets are described herein. According to some aspects, a plurality of addresses associated with an asset are compiled from sources such as database systems. For the plurality of address records, scores that correspond to attributes of the address records can be determined. Attributes associated with the address records may include a recency, a source, a date, license plate data, or address type, to name several non-limiting examples. Additionally, a zone of interest for the asset can be determined based on the plurality of address records. The plurality of address records is prioritized based on their distance from the zone of interest and the scores associated with them and, based on the priority, a subset of the plurality of address records is sent to, for example, a service provider.

Abstract: Probiotic compositions containing non-pathogenic microbial entities, e.g., bacterial entities, are described herein. The probiotic compositions may optionally contain or be used in conjunction with one or more prebiotics. Uses of the probiotic compositions to treat or prevent disorders of the local or systemic microbiome in a subject are also provided.

Abstract: A method of encoding image data, including: frequency-transforming input image data to generate an array of frequency-transformed input image coefficients by a matrix-multiplication process, according to a maximum dynamic range of the transformed data and using transform matrices having a data precision; and selecting the maximum dynamic range and/or the data precision of the transform matrices according to the bit depth of the input image data.

Abstract: A fluid container having a proximal end having an end wall, a distal end having an open-ended neck, and a sidewall extending between the proximal end and the distal end along a longitudinal axis is described. A localized crystallinity of a polymeric material of the fluid container of at least a first region of the fluid container is greater than a crystallinity of a polymeric material of the fluid container of at least a second region. Examples of fluid containers include medical fluid containers, such as medical bottles and syringes, including rolling diaphragm-type syringes, and commercial beverage containers Articles of manufacturer formed form a polymeric material and having regions with increased localized polymeric crystallinity are also described.