Patents by Inventor David Bickers

David Bickers has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • AKT and SHH Pathway Inhibitor Combination Therapy for Treating Basal Cell Carcinomas
    Publication number: 20170290849
    Abstract: A mechanism whereby aberrant Shh signaling converges on the Akt1-mTOR pathway, conferring selective growth advantage and enhanced survival of tumor cells has been identified. Utilizing a mouse model of BCNS, a pivotal role has been discovered for Akt1 signaling in BCC tumorigenesis. Based on the results described here certain embodiments are directed to methods and pharmaceutical formulations for treating BCC/BCNS, other cancers that are Shh+ and Akt+, cancers that are Shh+ and mTOR plus and cancers that are Shh+ by administering therapeutically effective amounts of various combinations of Akt inhibitors, Shh pathway inhibitors such as SMO inhibitors, and mTOR inhibitors.
    Type: Application
    Filed: September 8, 2015
    Publication date: October 12, 2017
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Arianna L. Kim, David Bickers, Mohammad Athar