Patents by Inventor David Bleich

David Bleich has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Sepsis Prevention Through Adenosine Receptor Modulation
    Publication number: 20090041751
    Abstract: Methods for treating sepsis or septic shock in a patient comprising administering to said patient a therapeutically effective amount of a composition containing an adenosine A2a receptor antagonist.
    Type: Application
    Filed: February 1, 2006
    Publication date: February 12, 2009
    Applicant: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY
    Inventors: Gyorgy Hasko, Zoltan Nemeth, David Bleich, Edwin Deitch
  • Use of adeno-associated virus (AAV) to deliver genes
    Patent number: 6485976
    Abstract: This invention pertains to a method of protecting pancreatic &bgr;-cells from immune system-mediated cell damage through transduction of the cells with an adeno-associated viral vector encoding cytoprotective genes. These protected cells are suitable for transplantation into mammals and will be protected from rejection by the host. The method also may be used to protect pancreatic islet &bgr;-cells in situ for the primary prevention of immune-mediated destruction which leads to Type 1 diabetes. Pancreatic &bgr;-cells may be transduced with AAV vectors according to the invention for in vivo or ex vivo gene therapy.
    Type: Grant
    Filed: April 28, 2000
    Date of Patent: November 26, 2002
    Assignee: City of Hope
    Inventors: Jerry L. Nadler, David Bleich, Konkal-Matt R. Prasad
  • Inhibition of inflammation via inhibition of COX-2 gene transcription
    Patent number: 6469063
    Abstract: The present invention is directed to a method of treating inflammation comprising administering to a subject in need thereof an amount of a caffeic acid derivative sufficient to inhibit the transcription of COX-2. In a preferred embodiment the caffeic acid derivative is a cyanocinnamate, most preferably cinnamamyl-3,4-dihydroxy-&agr;-cyanocinnamate.
    Type: Grant
    Filed: November 17, 2000
    Date of Patent: October 22, 2002
    Assignee: City of Hope
    Inventors: David Bleich, Songyuan Chen, Xiao Han