Patents by Inventor David Bol

David Bol has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polynucleotide encoding a novel TRP channel family member, TRP-PLIK2, and splice variants thereof
    Publication number: 20070172880
    Abstract: The present invention provides novel polynucleotides encoding TRP-PLIK2 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding variants and splice variants of TRP-PLIK2 polypeptides, TRP-PLIK2b, TRP-PLIK2c, and TRP-PLIK2d, respectively. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel TRP-PLIK2, TRP-PLIK2b, TRP-PLIK2c, and TRP-PLIK2d polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
    Type: Application
    Filed: March 21, 2007
    Publication date: July 26, 2007
    Inventors: Ning Lee, Jian Chen, John Feder, Shujian Wu, Han Chang, Liana Lee, Michael Blanar, David Bol
  • Polynucleotide encoding a TRP channel family member, TRP-PLIK2
    Patent number: 7223557
    Abstract: The present invention provides novel polynucleotides encoding TRP-PLIK2 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding variants and splice variants of TRP-PLIK2 polypeptides, TRP-PLIK2b, TRP-PLIK2c, and TRP-PLIK2d, respectively. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel TRP-PLIK2, TRP-PLIK2b, TRP-PLIK2c, and TRP-PLIK2d polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
    Type: Grant
    Filed: May 22, 2002
    Date of Patent: May 29, 2007
    Assignee: Bristol-Myers Squibb Company
    Inventors: Ning Lee, Jian Chen, John N. Feder, Shujian Wu, Han Chang, Liana M. Le, Michael A. Blanar, David Bol
  • Human G-protein coupled receptor, HGPRBMY11, and variants thereof
    Publication number: 20060229272
    Abstract: The present invention provides novel polynucleotides encoding HGPRBMY11 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding variants of the HGPRBMY11 polypeptide, HGPRBMY11v1 and HGPRBMY11v2. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing these polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY11, HGPRBMY11v1, and/or HGPRBMY11v2 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly gastrointestinal diseases and/or disorders, Crohn's disease, ovarian cancer, and diseases and disorders related to aberrant NFKB modulation. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
    Type: Application
    Filed: April 12, 2006
    Publication date: October 12, 2006
    Inventors: Lauren Barber, Angela Cacace, John Feder, Thomas Nelson, David Bol, Chandra Ramanathan
  • Polynucleotides encoding a novel human G-protein coupled receptor splice variant HGPRBMY29sv1
    Patent number: 7049096
    Abstract: The present invention provides novel polynucleotides encoding HGPRBMY28 and HGPRBMY29 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding splice variants of HGPRBMY29 polypeptides, HGPRBMY29v1 and HGPRBMY29v2. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY28, HGPRBMY29, HGPRBMY29v1, and HGPRBMY29v2 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
    Type: Grant
    Filed: April 11, 2002
    Date of Patent: May 23, 2006
    Assignee: Bristol-Meyers Squibb Company
    Inventors: John N. Feder, Chandra S. Ramanathan, Gabriel A. Mintier, David Bol, Donald R. Hawken
  • PRMTs as modifiers of the p53 pathway and methods of use
    Publication number: 20060024665
    Abstract: Human PRMT genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of PRMT are provided.
    Type: Application
    Filed: September 30, 2005
    Publication date: February 2, 2006
    Inventors: Lori Friedman, Gregory Plowman, Marcia Belvin, Helen Francis-Lang, Danxi Li, Roel Funke, Rolf Ryseck, Lata Jayaraman, David Bol, Matthew Lorenzi
  • Human phosphatase RET31, and variants thereof
    Publication number: 20060014180
    Abstract: The present invention provides novel polynucleotides encoding human phosphatase polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel human phosphatase polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly cardiovascular diseases and/or disorders. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
    Type: Application
    Filed: June 2, 2005
    Publication date: January 19, 2006
    Inventors: Donald Jackson, Chandra Ramanathan, John Feder, Gabe Mintier, Liana Lee, Thomas Nelson, Nathan Siemers, David Bol, Suzanne Suchard, Gary Schieven, Joshua Finger, C. Todderrud, Donna Bassolino, Stanley Krystek, Dana Banas, Patrick McAtee
  • Human leucine-rich repeat containing protein expressed predominately in bone marrow, HLRRBM1
    Publication number: 20050203048
    Abstract: The present invention provides novel polynucleotides encoding HLRRBM1 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HLRRBM1 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly immune diseases and/or disorders. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
    Type: Application
    Filed: April 15, 2005
    Publication date: September 15, 2005
    Inventors: John Feder, Chandra Ramanathan, Gabriel Mintier, David Bol, Donald Hawken
  • Human coactivator-associated arginine methyltransferase 1 (hCARM1)
    Publication number: 20050196753
    Abstract: Human coactivator-associated arginine methyltransferase 1 (hCARM1) polynucleotides and polypeptides. Also provided are expression vectors, recombinant host cells and processes for producing recombinant host cells, processes for producing said polypeptides, and methods for identifying substances that are capable of interacting with a coactivator-associated arginine methyltransferase 1 molecule.
    Type: Application
    Filed: May 30, 2003
    Publication date: September 8, 2005
    Inventors: Lata Jayaraman, Rolf Ryseck, Matthew Lorenzi, David Bol
  • PRMTs as modifiers of the p53 pathway and methods of use
    Publication number: 20050186566
    Abstract: Human PRMT genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of PRMT are provided.
    Type: Application
    Filed: June 5, 2002
    Publication date: August 25, 2005
    Inventors: Lori Friedman, Gregory Plowman, Marcia Belvin, Helen Francis-Lang, Danxi Li, Roel Funke, Rolf Ryseck, Lata Jayaraman, David Bol, Matthew Lorenzi
  • Novel human G-protein coupled receptor, HGPRBMY29sv1 polypeptides
    Publication number: 20050148016
    Abstract: The present invention provides novel polynucleotides encoding HGPRBMY28 and HGPRBMY29 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding splice variants of HGPRBMY29 polypeptides, HGPRBMY29v1 and HGPRBMY29v2. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY28, HGPRBMY29, HGPRBMY29v1, and HGPRBMY29v2 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
    Type: Application
    Filed: March 2, 2005
    Publication date: July 7, 2005
    Inventors: John Feder, Chandra Ramanathan, Gabriel Mintier, David Bol, Donald Hawken
  • POLYNUCLEOTIDES ENCODING NOVEL HUMAN PHOSPHATASES
    Publication number: 20050130286
    Abstract: The present invention provides novel polynucleotides encoding human phosphatase polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel human phosphatase polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly cardiovascular diseases and/or disorders. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
    Type: Application
    Filed: December 20, 2001
    Publication date: June 16, 2005
    Inventors: Donald Jackson, Chandra Ramanathan, John Feder, Gabe Mintier, Liana Lee, Thomas Nelson, Nathan Siemers, David Bol, Suzanne Suchard, Gary Schieven, Joshua Finger, C. Todderrud, Donna Bassolino, Stanley Krystek, Dana Banas, Patrick McAtee
  • Polynucleotide encoding a novel TRP channel family member, LTRPC3, and splice variants thereof
    Publication number: 20030224450
    Abstract: The present invention provides novel polynucleotides encoding LTRPC3 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding variants and splice variants of LTRPC3 polypeptides, LTRPC3b, LTRPC3c, LTRPC3d, LTRPC3e, and LTRPC3f, respectively. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel LTRPC3, LTRPC3b, LTRPC3c, LTRPC3d, LTRPC3e, and LTRPC3f polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
    Type: Application
    Filed: March 28, 2003
    Publication date: December 4, 2003
    Inventors: Ning Lee, Jian Chen, John N. Feder, Shujian Wu, Liana M. Lee, Michael A. Blanar, David Bol, Paul C. Levesque, Lucy Sun
  • Polynucleotide encoding a novel TRP channel family member, LTRPC3, and splice variants thereof
    Publication number: 20030162189
    Abstract: The present invention provides novel polynucleotides encoding LTRPC3 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding variants and splice variants of LTRPC3 polypeptides, LTRPC3b, LTRPC3c, LTRPC3d, LTRPC3e, and LTRPC3f, respectively. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel LTRPC3, LTRPC3b, LTRPC3c, LTRPC3d, LTRPC3e, and LTRPC3f polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
    Type: Application
    Filed: August 1, 2002
    Publication date: August 28, 2003
    Inventors: Ning Lee, Jian Chen, John Feder, Shujian Wu, Liana Lee, Michael A. Blanar, David Bol, Paul C. Levesque, Lucy Sun
  • Polynucleotide encoding a novel TRP channel family member, TRP-PLIK2, and splice variants thereof
    Publication number: 20030144191
    Abstract: The present invention provides novel polynucleotides encoding TRP-PLIK2 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding variants and splice variants of TRP-PLIK2 polypeptides, TRP-PLIK2b, TRP-PLIK2c, and TRP-PLIK2d, respectively. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel TRP-PLIK2, TRP-PLIK2b, TRP-PLIK2c, and TRP-PLIK2d polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
    Type: Application
    Filed: May 22, 2002
    Publication date: July 31, 2003
    Inventors: Ning Lee, Jian Chen, John N. Feder, Shujian Wu, Han Chang, Liana Lee, Michael A. Blanar, David Bol
  • Polynucleotides encoding two novel human G-protein coupled receptors, HGPRBMY28 and HGPRBMY29, and splice variants thereof
    Publication number: 20030096347
    Abstract: The present invention provides novel polynucleotides encoding HGPRBMY28 and HGPRBMY29 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding splice variants of HGPRBMY29 polypeptides, HGPRBMY29v1 and HGPRBMY29v2. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY28, HGPRBMY29, HGPRBMY29v1, and HGPRBMY29v2 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
    Type: Application
    Filed: April 11, 2002
    Publication date: May 22, 2003
    Inventors: John N. Feder, Chandra S. Ramanathan, Gabriel A. Mintier, David Bol, Donald R. Hawken
  • G-protein coupled receptor nucleic acids, polypeptides, antibodies and uses thereof
    Publication number: 20030064438
    Abstract: The invention provides isolated HGPRBMY1 and HGPRBMY2 nucleic acid molecules and polypeptide molecules. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
    Type: Application
    Filed: February 22, 2002
    Publication date: April 3, 2003
    Inventors: John N. Feder, Chandra S. Ramanathan, Thomas C. Nelson, Gabriel A. Mintier, Angela Cacace, Lauren E. Barber, Michael Kornacker, David Bol