Patents by Inventor David Bonnaffe

David Bonnaffe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9907860
    Abstract: This invention relates to a conjugated molecule comprising a peptide derived from the CD4 receptor coupled to an organic molecule by means of a linker as well as a process for its preparation. Said organic molecule comprises a 5 to 21 amino acid anionic polypeptide. Such a conjugated molecule can be used in antiviral treatment, namely in the treatment of AIDS.
    Type: Grant
    Filed: October 23, 2015
    Date of Patent: March 6, 2018
    Assignees: INSTITUT PASTEUR, COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, UNIVERSITE PARIS-SUD, UNIVERSITE GRENOBLE ALPES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Francoise Baleux, Hugues Lortat-Jacob, David Bonnaffe, Yves-Marie Coic
  • Publication number: 20170326246
    Abstract: This invention relates to a conjugated molecule comprising a peptide derived from the CD4 receptor coupled to an organic molecule by means of a linker as well as a process for its preparation. Said organic molecule comprises a 5 to 21 amino acid anionic polypeptide. Such a conjugated molecule can be used in antiviral treatment, namely in the treatment of AIDS.
    Type: Application
    Filed: October 23, 2015
    Publication date: November 16, 2017
    Inventors: Francoise BALEUX, Hugues LORTAT-JACOB, David BONNAFFE, Yves-Marie COÏC
  • Patent number: 9295730
    Abstract: This invention relates to a conjugated molecule comprising a peptide derived from the CD4 receptor coupled to an organic molecule by means of a linker as well as a process for its preparation. Such a conjugated molecule can be used in antiviral treatment, namely in the treatment of AIDS.
    Type: Grant
    Filed: January 27, 2009
    Date of Patent: March 29, 2016
    Assignees: Institut Pasteur, Commissariat A L'Energie Atomique Et Aux Eneergies Alternatives, Centre National De La Recherche Scientifique (CNRS)
    Inventors: Françoise Baleux, David Bonnaffe, Hugues Lortat-Jacob, Latino Loureiro-Morais
  • Patent number: 9078928
    Abstract: This invention relates to a conjugated molecule comprising a peptide derived from the CD4 receptor coupled to an organic molecule by means of a linker as well as a process for its preparation. Said organic molecule comprises a 5 to 21 amino acid anionic polypeptide. Such a conjugated molecule can be used in antiviral treatment, namely in the treatment of AIDS.
    Type: Grant
    Filed: March 16, 2012
    Date of Patent: July 14, 2015
    Assignee: Institut Pasteur
    Inventors: Françoise Baleux, Hugues Lortat-Jacob, David Bonnaffe
  • Publication number: 20150037909
    Abstract: The present invention relates to a sensor for an electronic tongue or nose for analysing a sample or detecting a target. The sensor comprises a support, on one surface of which a plurality of sensitive areas are located, each sensitive area comprising at least one receptor and being capable of transmitting a measurable signal generated by the interaction of at least one constituent of the sample or one target with at least one receptor. The sensor is characterised in that it comprises at least three sensitive areas that differ from one another in terms of their respective receptor compositions, at least one of the sensitive areas comprising a mixture of at least two different receptors, while the two other sensitive areas each comprise at least one of the two receptors.
    Type: Application
    Filed: February 21, 2013
    Publication date: February 5, 2015
    Applicants: Centre National de la Recherche Scientifique, UNIVERSITE PARIS-SUD, Commissariat a l'Energie Atomique et aux Energies Alternatives
    Inventors: Thierry Livache, Arnaud Buhot, David Bonnaffe, Yanxia Hou-Broutin
  • Publication number: 20140107043
    Abstract: This invention relates to a conjugated molecule comprising a peptide derived from the CD4 receptor coupled to an organic molecule by means of a linker as well as a process for its preparation. Said organic molecule comprises a 5 to 21 amino acid anionic polypeptide. Such a conjugated molecule can be used in antiviral treatment, namely in the treatment of AIDS.
    Type: Application
    Filed: March 16, 2012
    Publication date: April 17, 2014
    Inventors: Françoise Baleux, Hugues Lortat-Jacob, David Bonnaffe
  • Patent number: 8541604
    Abstract: The present invention is targeted at a novel coupling method of 1,3-dipolar cycloaddition type which is of particular use for the functionalization of biological molecules, such as, for example, proteins, enzymes or nucleic acids, insofar as it can be carried out in an aqueous medium and at ambient temperature.
    Type: Grant
    Filed: October 15, 2010
    Date of Patent: September 24, 2013
    Assignee: Commissariat a l'Energie Atomique et aux Energies Alternatives
    Inventors: Aude Bernardin, David Bonnaffe, Isabelle Texier-Nogues
  • Publication number: 20110118484
    Abstract: The present invention is targeted at a novel coupling method of 1,3-dipolar cycloaddition type which is of particular use for the functionalization of biological molecules, such as, for example, proteins, enzymes or nucleic acids, insofar as it can be carried out in an aqueous medium and at ambient temperature.
    Type: Application
    Filed: October 15, 2010
    Publication date: May 19, 2011
    Applicant: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
    Inventors: Aude Bernardin, David Bonnaffe, Isabelle Texier-Nogues
  • Publication number: 20110105412
    Abstract: This invention relates to a conjugated molecule comprising a peptide derived from the CD4 receptor coupled to an organic molecule by means of a linker as well as a process for its preparation. Such a conjugated molecule can be used in antiviral treatment, namely in the treatment of AIDS.
    Type: Application
    Filed: January 27, 2009
    Publication date: May 5, 2011
    Inventors: Françoise Baleux, David Bonnaffe, Hugues Lortat-Jacob, Latino Loureiro-Morais
  • Publication number: 20110015368
    Abstract: The present invention relates to an activated peptide derived from the CD4 receptor, which is capable of coupling by covalent bonding to an organic molecule and thus makes it possible to generate multiple potentially antiviral derivatives. The present invention also relates to a conjugated molecule comprising the CD4-receptor-derived peptide and an organic molecule, preferably the GPR1 peptide or a polyanion. Such a conjugated molecule can in particular be used in antiviral treatments, in particular the treatment of AIDS. The invention also relates to the methods for preparing the activated peptide derived from the CD4 receptor and the conjugated molecule.
    Type: Application
    Filed: August 3, 2007
    Publication date: January 20, 2011
    Inventors: Françoise Baleux, David Bonnaffe, Hugues Lortat-Jacob
  • Publication number: 20080044838
    Abstract: The present invention relates to a molecular spacer arm, to a process for attachment of a molecular unit to a solid support, and also to the use of this spacer arm on analytical chips comprising molecules or biomolecules. The spacer arm has the formula (I): in which X0, X4?C, O, S, Se, N, P, As; X1-3?C, O, N, S, Se, P, As, or C1-6 aryl or heteroaryl; Z1-2?C—R, Si—R, N, P and As, where R?C1-6 alkyl; R1-3?H, or C1-6 alkyl, aryl or heteroaryl; [Gp]=protective group for >N; n, m and p=integers ?1; [Sup]=H or a silanized solid support; and [mo]=H or a molecular unit intended to be covalently attached to said silanized solid support by means of said spacer arm.
    Type: Application
    Filed: August 22, 2006
    Publication date: February 21, 2008
    Applicant: Commissariat A L'Energie Atomique
    Inventors: Ve´ronique PERETTI, Françoise VINET, David BONNAFFE
  • Publication number: 20070190570
    Abstract: The present invention relates to a molecular spacer arm, to a process for attachment of a molecular unit to a solid support, and also to the use of this spacer arm on analytical chips comprising molecules or biomolecules. The spacer arm has the formula (I): in which X0, X4=C, O, S, Se, N, P, As; X1-3=C, O, N, S, Se, P, As, or C1-6 aryl or heteroaryl; Z1-2=C—R, Si—R, N, P and As, where R=C1-6 alkyl; R1-3=H, or C1-6 alkyl, aryl or heteroaryl; [Gp]=protective group for >N; n, m and p=integers?1; [Sup]=H or a silanized solid support; and [mo]=H or a molecular unit intended to be covalently attached to said silanized solid support by means of said spacer arm.
    Type: Application
    Filed: February 22, 2005
    Publication date: August 16, 2007
    Applicant: COMMISSARIAT A L'ENERGIE ATOMIQUE
    Inventors: Veronique Peretti, Francoise Vinet, David Bonnaffe
  • Publication number: 20060166927
    Abstract: Compound capable of binding to gamma-interferon (?-IFN), chosen from the molecules corresponding to formula (I) below: in which X is a divalent spacer group that is sufficiently long to allow the two oligosaccharide fragments A and B to each bind to one of the peptide sequences 125 to 143 of the C-terminal ends of a ?-interferon (?-IFN) homodimer, n represents an integer from 0 to 10, and for example equal to 0, 1, 2, 3, 4 or 5, and each R independently represents a hydrogen atom, an SO3? group or a phosphate group, on the condition that no SO3? group is in the 3-position of the glucosamine units of compound (I). The invention also relates to the process for preparing these compounds, to the complexes formed by these compounds and gamma-interferon, and to the medicaments comprising these compounds or complexes.
    Type: Application
    Filed: June 18, 2003
    Publication date: July 27, 2006
    Inventors: David Bonnaffe, Andre Lubineau, Jocelyne Alais, Olivier Gavard, Anna Dilhas, Hugues Lortat-Jacob
  • Patent number: 5262525
    Abstract: Method for the chemical modification of proteins using a reagent of general formula ##STR1## obtained from the diene ##STR2## and maleic anhydride by Diels-Alder addition.
    Type: Grant
    Filed: March 19, 1992
    Date of Patent: November 16, 1993
    Assignee: Societe Nationale Elf Aquitaine
    Inventors: David Bonnaffe, Andre Lubineau, Jean-Louis Seris, Michel Therisod