Abstract: The various examples of the present disclosure are directed towards systems and methods for diagnosing brain health. An exemplary system includes a microscope, a processor, and a memory. The microscope outputs image data of a cornea of a patient. The memory has a plurality of stored code sections, which, when executed by the processor, include instructions for analyzing cornea image data to determine brain health. The instructions begin with receiving cornea image data from the microscope. The instructions then provide for determining at least one marker from the received cornea image data. The instructions then provide for outputting a brain health diagnosis based on the at least one marker.

Abstract: An ongoing pain detection system and method are provided. The method includes obtaining imaging data from patient using functional near-infrared spectroscopy from at least one cortical region of the brain of a non-responsive patient and observing power spectral density variations in the signal. The measured imaging data is compared with patient pain based on control data to recognize ongoing pain in the non-responsive patient.

Abstract: The various examples of the present disclosure are directed towards systems and methods for diagnosing brain health. An exemplary system includes a microscope, a processor, and a memory. The microscope outputs image data of a cornea of a patient. The memory has a plurality of stored code sections, which, when executed by the processor, include instructions for analyzing cornea image data to determine brain health. The instructions begin with receiving cornea image data from the microscope. The instructions then provide for determining at least one marker from the received cornea image data. The instructions then provide for outputting a brain health diagnosis based on the at least one marker.

Abstract: Disclosed is a pain detection system and method. Preferred methods include capturing imaging data from patient using functional near-infrared spectroscopy. In methods of the invention, pain may be assessed from a non-responsive patient. Preferred methods may further include measuring hemodynamic parameters using the optical imaging data and averaging the measured hemodynamic parameters to reduce background noise. Additionally, a pattern in the averaged hemodynamic parameters is identified and the pattern is compared to a predetermined associated with patient pain. The method further includes detecting, by the processor, a similarity between the pattern and the predetermined pattern and outputting a signal indicating patient pain.

Abstract: A method includes: identifying, by a processing circuit, diffusion tensor imaging (DTI) data of a peripheral nerve in a subject that is associated with an area of pain experienced by the subject; determining, by the processing circuit, one or more DTI-derived measurements from the DTI data for each of one or more nerve branches of the peripheral nerve; and detecting, by the processing circuit, potential nerve damage in a particular nerve branch of the one or more nerve branches based on the one or more DTI-derived measurements associated with the particular nerve branch.

Abstract: Disclosed is a pain detection system and method. Preferred methods include capturing imaging data from patient using functional near-infrared spectroscopy. In methods of the invention, pain may be assessed from a non-responsive patient. Preferred methods may further include measuring hemodynamic parameters using the optical imaging data and averaging the measured hemodynamic parameters to reduce background noise. Additionally, a pattern in the averaged hemodynamic parameters is identified and the pattern is compared to a predetermined associated with patient pain. The method further includes detecting, by the processor, a similarity between the pattern and the predetermined pattern and outputting a signal indicating patient pain.

Abstract: A method for recognizing awareness in a subject includes performing optical imaging on at least one cortical region of the brain of the subject. Optical imaging data are obtained over time measuring one or more hemodynamic parameters in the at least one cortical region of the subject's brain. An observed variation pattern is determined in the measured hemodynamic parameters, and the observed variation pattern is compared to one or more known variation patterns characteristic of awareness. Substantial similarity between the observed and known variation patterns signals awareness in the subject.

Abstract: In general, the invention provides methods and compositions for treating sequela of weight gain or pain insensitivity, e.g., in a subject suffering from a psychiatric disorder, such as schizophrenia. The combinations employed in the invention include a second generation antipsychotic agent and an opioid receptor antagonist.

Abstract: Evaluating hemodynamic parameters in the cortex can be used as an objective test for CNS activity, e.g., pain.

Abstract: In general, the invention features methods for identifying therapeutic interventions for functional illnesses, e.g., neuropathic pain or depression, and methods for identifying markers for functional illnesses by employing an acute painful stimulus or other stimulus for a functional illness and measuring levels of CNS activity.

Abstract: A method for recognizing awareness in a subject includes performing optical imaging on at least one cortical region of the brain of the subject. Optical imaging data are obtained over time measuring one or more hemodynamic parameters in the at least one cortical region of the subject's brain. An observed variation pattern is determined in the measured hemodynamic parameters, and the observed variation pattern is compared to one or more known variation patterns characteristic of awareness. Substantial similarity between the observed and known variation patterns signals awareness in the subject.

Abstract: Methods of providing pain relief by administering a water-soluble derivative of spicamycin. Methods of using pain mediation agents are also provided.

Abstract: In general, the invention provides methods and compositions for treating sequela of weight gain or pain insensitivity, e.g., in a subject suffering from a psychiatric disorder, such as schizophrenia. The combinations employed in the invention include a second generation antipsychotic agent and an opioid receptor antagonist.

Abstract: Methods of providing pain relief by administering a water-soluble derivative of spicamycin. Methods of using pain mediation agents are also provided.

Abstract: Methods of providing pain relief by administering a water-soluble derivative of spicamycin. Methods of using pain mediation agents are also provided.

Abstract: A method and apparatus for evaluating motivational and emotional circuitry in the brain during paradigms focused on specific motivational functions, to directly determine which components and how much the motivational and emotional brain circuitry responds. This circuitry response answers questions focused on normal and abnormal behavior, along with questions regarding the normal and abnormal function of the circuitry. The results of interrogating the motivational and emotional circuitry can be used for objectively measuring, in individual humans or animals, their preferences or responses to motivationally salient stimuli including but not limited to stimuli which are internal or external, conscious or non-conscious, pharmacological or non-pharmacological therapies, diseased based processes or not, financial or non-financial, etc.

Abstract: Methods of providing pain relief by administering a water-soluble derivative of spicamycin. Methods of using pain mediation agents are also provided.

Abstract: Methods of providing pain relief by administering a water-soluble derivative of spicamycin. Methods of using pain mediation agents are also provided.

Abstract: This invention features methods for identifying targets for analgesic therapy by comparing the results of functional magnetic resonance imaging in non-human test subjects having genetically-based differences in their neural responses to painful stimuli.

Abstract: In general, the invention features methods for identifying therapeutic interventions for functional illnesses, e.g., neuropathic pain or depression, and methods for identifying markers for functional illnesses by employing an acute painful stimulus or other stimulus for a functional illness and measuring levels of CNS activity.