Abstract: A system and method are provided to improve physiological function in a patient having a spinal cord lesion or quantify the state of the spinal cord and thus the state of progression of the spinal cord lesion. The system and method use spinal electrophysiological data, such as ECAPs, to determine a patient's physiological state and direct delivery of spinal cord stimulation in response to the determination of the patient's physiological state to achieve a therapeutic effect.

Abstract: In accordance with some embodiments of the disclosed subject matter, mechanisms (which can, for example, include systems, methods, and media) for detecting an effortful mental state providing real-time deep brain stimulation to enhance performance of effortful mental tasks are provided.

Abstract: Methods and systems for improved removal of deep brain stimulation artifacts from electrical measurements of brain activity. In one embodiment, a method is provided that includes: receiving, by a computing device having a processor, waveform data caused by a deep brain stimulation of a patient-specific area of interest; determining, by the computing device, a stimulation period relative to a sampling rate; identifying, by the computing device and based on the waveform data and the stimulation period, a stimulation artifact; subtracting, by the computing device, the identified stimulation artifact from the received waveform data; and generating, in real-time, a filtered waveform data indicating an absence of the stimulation artifact.

Abstract: A system includes spatially isolated nodes proximal to a cortical surface or spinal cord, a telemetric antenna array located above the dura, the telemetric antenna array configured to provide power to and exchange data with the spatially isolated nodes, and a power and data distribution unit configured to power the spatially isolated nodes, aggregate recorded data, send the aggregated recorded data and commands through a wireless link.

Abstract: In accordance with some embodiments of the disclosed subject matter, mechanisms (which can, for example, include systems, methods, and media) for detecting an effortful mental state providing real-time deep brain stimulation to enhance performance of effortful mental tasks are provided.

Abstract: A system includes spatially isolated nodes proximal to a cortical surface or spinal cord, a telemetric antenna array located above the dura, the telemetric antenna array configured to provide power to and exchange data with the spatially isolated nodes, and a power and data distribution unit configured to power the spatially isolated nodes, aggregate recorded data, send the aggregated recorded data and commands through a wireless link.

Abstract: Systems and methods for providing an electrical interface to a body are provided. In one embodiment, an implantable module is disclosed, comprising: an implantable electrode array, implantable within a body and capable of providing a plurality of communication channels for communicating electrical signals detected in a body; an amplifier circuit for processing electrical signals received from the electrode array; a wireless transceiver for sending and receiving telemetry data between the amplifier circuit and a wireless receiver located outside of the body; and a sealed enclosure that houses the amplifier circuit and the wireless transmitter and is biocompatible with surrounding tissue, the enclosure having a window that is transparent to a wireless medium used by the wireless transceiver.

Abstract: A polymer film coating for medical devices and medical devices with coating are provided to controllably release one or more therapeutics or other agents locally at the tissue-device interface for a prolonged period of time. The coating can be prepared via layer by layer (LbL) assembly of polymers and/or polymers conjugated to or otherwise associated with one or more drugs, particularly recyclable antioxidants or antioxidant regulators. The resulting coating contains alternating layers that are assembled via electrostatic interactions, hydrogen bonding, or other secondary interactions. The coated device can provide for long term local delivery of antioxidants, preferably antioxidant upregulators and/or recyclable antioxidants, to modulate the oxidative stress associated with brain implants.

Abstract: Systems and methods for providing an electrical interface to a body are provided. In one embodiment, an implantable module is disclosed, comprising: an implantable electrode array, implantable within a body and capable of providing a plurality of communication channels for communicating electrical signals detected in a body; an amplifier circuit for processing electrical signals received from the electrode array; a wireless transceiver for sending and receiving telemetry data between the amplifier circuit and a wireless receiver located outside of the body; and a sealed enclosure that houses the amplifier circuit and the wireless transmitter and is biocompatible with surrounding tissue, the enclosure having a window that is transparent to a wireless medium used by the wireless transceiver.

Abstract: A solar energy concentrator system includes a supporting structure and a plurality of solar modules coupled to the supporting structure. Each module of the plurality of solar modules includes a plurality of Fresnel reflectors. The plurality of reflectors is arranged to focus solar radiation linearly onto a photovoltaic cell providing two axis concentration. The supporting structure is rotatably connected to a plurality of support members and aligned to allow the supporting structure to rotate about a polar axis. A plurality of optical trusses is connected to the plurality of solar modules and rotatably connected to the supporting structure to allow the plurality of solar modules to be rotated about a declination axis to track a motion of the sun through seasons of the year.

Abstract: A solar energy concentrator system includes a supporting structure and a plurality of solar modules coupled to the supporting structure. Each module of the plurality of solar modules includes a plurality of Fresnel reflectors. The plurality of reflectors is arranged to focus solar radiation linearly onto a photovoltaic cell providing two axis concentration. The supporting structure is rotatably connected to a plurality of support members and aligned to allow the supporting structure to rotate about a polar axis. A plurality of optical trusses is connected to the plurality of solar modules and rotatably connected to the supporting structure to allow the plurality of solar modules to be rotated about a declination axis to track a motion of the sun through seasons of the year.

Abstract: A Fresnel lens comprising a substantially polygonal focusing portion adapted to focus solar radiation to a area having the same geometry as the focusing portion of the lens. Also a solar module comprising the Fresnel collecting lens and a substantially polygonal photovoltaic cell. The photovoltaic cell is mounted at distance from the Fresnel collecting lens so that the size of the area substantially matches the size of the photovoltaic cell. Also a solar panel having multiple modules within a glazed building envelope system. The solar panel also includes an actuating mechanism within the glazed window envelope system. The actuating mechanism is operatively connected to the plurality of solar modules and is adapted to move the solar modules to track the sun.