Abstract: Disclosed herein are subcutaneously administered, immunogenic compositions (e.g., vaccines) and methods of using and preparing the same. In some embodiments, the immunogenic compositions generate IgG antibodies to the spike proteins of the Wuhan-Hu-1, Delta B.1.617.2, and Omicron BA.1 variants of SARS-CoV-2 and may be suitable for use in preventing an infectious disease, such as SARS-CoV-2.

Abstract: Delivery apparatus and methods for delivering a medical device into a patient's vasculature are disclosed. In some examples, a method includes inserting, into a patient, a distal end portion of a delivery apparatus including a radially compressed prosthetic valve mounted around a balloon, advancing the distal end through the patient's vasculature, and inflating the balloon to radially expand the prosthetic valve at a native heart valve. The delivery apparatus includes a handle, a first shaft and a second shaft extending from the handle, and a locking mechanism to prevent axial movement of the second shaft relative to first shaft. The second shaft extends coaxially through the first shaft and includes the balloon, the radially compressed prosthetic valve, and one or more radiopaque markers at a distal end portion. The first shaft includes an end piece covering a proximal portion of the balloon during the advancing of the delivery apparatus.

Abstract: Disclosed herein are adjuvanted protein vaccines comprising: a SARS-CoV-2 variant C.1.2 modified S1 Spike protein sequence and a non-phospholipid liposome, wherein the protein is encapsulated within the non-phospholipid liposome. The adjuvanted protein vaccines are suitable for subcutaneous administration. Also disclosed herein are modified spike protein sequences containing SARS-CoV-2 variant C.1.2 modified S1 Spike proteins and methods of use of the vaccines and sequences.

Abstract: The present disclosure relates to methods for reducing host cell protein content in antibody preparation recombinantly produced in a host cell in the manufacturing process of antibodies intended for administration to a patient. The disclosed methods may be performed in order to prepare therapeutic antibody preparations having reduced host cell protein.

Abstract: The present disclosure relates to methods for reducing host cell protein content in a protein preparation recombinantly produced in a host cell in the manufacturing process of proteins intended for administration to a patient.

Abstract: A superhard construction comprises a substrate comprising a peripheral surface, an interface surface and a longitudinal axis and a super hard material layer formed over the substrate and having an exposed outer surface forming a working surface, a peripheral surface extending therefrom and an interface surface. One of the interface surface of the substrate or the interface surface of the super hard material layer comprises one or more projections arranged to project from the interface surface, the height of the one or more projections being between around 0.2 mm to around 1.0 mm measured from the lowest point on the interface surface from which the one or more projections extend.

Abstract: A superhard construction comprises a substrate comprising a peripheral surface, an interface surface and a longitudinal axis and a super hard material layer formed over the substrate and having an exposed outer surface forming a working surface, a peripheral surface extending therefrom and an interface surface. One of the interface surface of the substrate or the interface surface of the super hard material layer comprises one or more projections arranged to project from the interface surface, the height of the one or more projections being between around 0.2 mm to around 1.0 mm measured from the lowest point on the interface surface from which the one or more projections extend.

Abstract: Embodiments of the invention provide methods, systems, and program products for managing information, including the incremental release of information from a restricted database of information, such that the incremental release is consistent with relationships between and among a plurality of pieces of information within the restricted database.

Abstract: A superhard construction comprises a substrate (10) comprising a peripheral surface, an interface surface (18) and a longitudinal axis and a super hard material layer (12) formed over the substrate and having an exposed outer surface forming a working surface (14), a peripheral surface extending therefrom and an interface surface. One of the interface surface of the substrate or the interface surface of the super hard material layer comprises one or more projections (24, 26) arranged to project from the interface surface, the height of the one or more projections being between around 0.2 mm to around 1.0 mm measured from the lowest point on the interface surface from which the one or more projections extend.

Abstract: A polycrystalline superhard construction comprises a body of polycrystalline superhard material having two or more layers. A first layer differs from a second layer in one or more characteristics. The body has a thickness of greater than around 1.8 mm. A substrate is bonded to at least one of said layers, and one of the interface surface of the substrate or the body comprises one or more projections arranged to project from the interface surface, the height of the projection(s) being between around 0.2 mm to around 2.0 mm measured from the lowest point on the interface surface from which the one or more projections extend. At least a portion of the body of superhard material is substantially free of a catalyst material for the superhard material, and forms a thermally stable region extending a depth of at least around 300 microns from the working surface of the body of superhard material.

Abstract: Embodiments of the invention provide methods, systems, and program products for managing information, including the incremental release of information from a restricted database of information, such that the incremental release is consistent with relationships between and among a plurality of pieces of information within the restricted database.

Abstract: A magnetic drive comprises a plurality of identically shaped and sized permanent magnets for transmitting torque to a shaft through a nonmagnetic cylindrical barrier wherein the magnets have inner and outer cylindrical surfaces with the outer cylindrical surfaces having a radius substantially the same as the inner cylindrical surfaces.

Abstract: A sealess sump pump comprises an impeller chamber mounted at the bottom of a pump column, an impeller journaled in the impeller chamber, a rare earth driven magnet assembly fixed to rotate with the impeller, a rare earth driving magnet assembly mounted at the lower end of an elongate pump shaft and a nonmagnetic barrier between the driving and the driven magnet assemblies.

Abstract: A method for distillation of a multiple-component liquid/solid system, for example, used engine coolant at two different vaporizing pressures. One component, for example, water, is separated into one distillate stream at a first pressure and the other component, for example, ethylene glycol, is separated into another distillate stream at a second pressure. Each distillate stream is directed toward an individual storage tank.

Abstract: An axial flow liquid pump comprises an outer tube, an inner tube positioned within the outer tube, and a driven shaft journaled within the inner tube. An impeller is secured near to the lower end of the shaft. A conduit delivers liquid to be pumped from the exterior of the outer tube to the lower end of the inner tube. The conduit is sized for permitting liquid to be drawn into said impeller such that the pressure in the vicinity of the lower end of the inner tube is equal or less than the pressure at the exterior of the outer tube near the conduit intake but sufficient not to draw air down through the inner tube.

Abstract: An axial flow liquid pump comprises an outer tube, a smaller diameter inner tube, and a driven shaft journaled near the top of the inner tube. An upwardly opening cup-shaped rotor is secured in the lower end of the shaft such that a cylindrical sidewall is at least partially spaced between the inner tube and the outer tube. A helical flange is secured to the outer surface of the cylindrical sidewall. Radial passages are provided in said rotor below the helical flange. The passages are arranged to be above the lower end of the inner tube. A baffle plate having passages therein is secured just above the rotor.

Abstract: Disclosed herein is a process and apparatus for safely distilling relatively small batches of organic compounds such as paint solvents by directly and safely heating the compounds in a vessel having a relatively thick bottom with electrical heating units cast in it and a relatively thick side wall integrally attached to the bottom. The side wall may be integrally attached to the bottom by a weld that penetrates the joint between the side wall and bottom preferably by 100% in order to provide a complete heat transfer from the bottom to the side wall. The vessel is so designed so as to provide a relatively uniform temperature throughout the inner periphery of the vessel thereby avoiding hot spots and insuring that the hottest spot of the inner periphery of the vessel does not exceed the auto ignition temperature of the compound being processed.