Abstract: The present invention relates to methods of profiling tumours and characterisation of the tissue types associated with the tumours. A gene expression profile is obtained from the tissue sample, the genes ranked in order of their relative expression levels and the tissue type identified by comparing the gene ranking obtained with a database of relative gene expression level rankings of different tissue types. This gives a means to identify primary tumours and to determine the identity of a tumour of unknown primary. The invention also provides a method of treatment of a tumour by diagnosis of primary tumours identified by the methods described.

Abstract: Nucleic acid molecules encoding vertebrate telomerase are provided. Gene products, expression vectors and host cells suitable for expressing telomerase are also provided. Methods for identifying inhibitors of telomerase activity and inhibitor compositions are disclosed.

Abstract: Nucleic acid molecules encoding vertebrate telomerase are provided. Gene products, expression vectors and host cells suitable for expressing telomerase are also provided. Methods for identifying inhibitors of telomerase activity and inhibitor compositions are disclosed.

Abstract: The present invention provides a binding domain of the protein Siah, which is known to be an important protein in the ubiquination pathway. The domain is capable of binding substances, co-factors and interactors of the Siah protein. The invention also provides a zinc-binding and a dimerisation domain of Siah. Also provided are methods of screening compounds that are capable of interacting with the binding domain, as well as methods of treating diseases including cancer, infertility, and inflammation.

Abstract: Nucleic acid molecules encoding vertebrate telomerase are provided. Gene products, expression vectors and host cells suitable for expressing telomerase are also provided. Methods for identifying inhibitors of telomerase activity and inhibitor compositions are disclosed.