Patents by Inventor David Brakes

David Brakes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Attenuated live neospora vaccine
    Publication number: 20040062772
    Abstract: The present invention provides attenuated live cultures of the pathogenic protozoan parasite, Neospora, and live vaccines against neosporosis prepared therefrom which are useful in the prevention of clinical disease and abortion in mammals.
    Type: Application
    Filed: September 24, 2003
    Publication date: April 1, 2004
    Applicant: PFIZER INC
    Inventors: David A. Brake, Byron L. Blagburn, David S. Lindsay
  • Attenuated live neospora vaccine
    Patent number: 6656479
    Abstract: The present invention provides attenuated live cultures of the pathogenic protozoan parasite, Neospora, and live vaccines against neosporosis prepared therefrom which are useful in the prevention of clinical disease and abortion in mammals.
    Type: Grant
    Filed: September 12, 2001
    Date of Patent: December 2, 2003
    Assignee: Pfizer Inc.
    Inventors: David A Brake, Byron L Blagburn, David S Lindsay
  • Polynucleotide molecules encoding Neospora proteins
    Publication number: 20030180785
    Abstract: The present invention provides isolated polynucleotide molecules comprising nucleotide sequences encoding GRA1, GRA2, SAG1, MIC1 and MAG1 proteins from Neospora caninum, as well as recombinant vectors, transformed host cells, and recombinantly-expressed proteins. The present invention further provides a polynucleotide molecule comprising the nucleotide sequence of the bidirectional GRA1/MAG1 promoter of N. caninum. The present invention further provides genetic constructs based on the polynucleotide molecules of the present invention that are useful in preparing modified strains of Neospora cells for use in vaccines against neosporosis.
    Type: Application
    Filed: April 21, 2003
    Publication date: September 25, 2003
    Applicants: Pfizer, Inc., Pfizer Products, Inc.
    Inventors: B. Rajendra Krishnan, Rebecca Madura, Christine Yoder, Becky Durtschi, David A. Brake
  • Polynucleotide molecules encoding neospora proteins
    Patent number: 6600027
    Abstract: The present invention provides isolated polynucleotide molecules comprising nucleotide sequences encoding GRA1, GRA2, SAG1, MIC1 and MAG1 proteins from Neospora caninum, as well as recombinant vectors, transformed host cells, and recombinantly-expressed proteins. The present invention further provides a polynucleotide molecule comprising the nucleotide sequence of the bidirectional GRA1IMAGI promoter of N. caninum. The present invention further provides genetic constructs based on the polynucleotide molecules of the present invention that are useful in preparing modified strains of Neospora cells for use in vaccines against neosporosis.
    Type: Grant
    Filed: March 25, 1999
    Date of Patent: July 29, 2003
    Assignees: Pfizer, Inc., Pfizer Products, Inc.
    Inventors: B. Rajendra Krishnan, Rebecca Madura, Christine Yoder, Becky Durtschi, David A. Brake
  • Neospora vaccine
    Publication number: 20020058046
    Abstract: The present invention provides an homogenate prepared from cells of Neospora, and vaccines against neosporosis prepared therefrom which are useful in the prevention of clinical disease and abortion in mammals.
    Type: Application
    Filed: November 9, 2001
    Publication date: May 16, 2002
    Applicant: Pfizer Inc.
    Inventors: David A. Brake, Manuel Campos
  • Attenuated live neospora vaccine
    Publication number: 20020044952
    Abstract: The present invention provides attenuated live cultures of the pathogenic protozoan parasite, Neospora, and live vaccines against neosporosis prepared therefrom which are useful in the prevention of clinical disease and abortion in mammals.
    Type: Application
    Filed: September 12, 2001
    Publication date: April 18, 2002
    Inventors: David A. Brake, Byron L. Blagburn, David S. Lindsay