Patents by Inventor David Bregman

David Bregman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20060052319
    Abstract: This invention relates to the fields of molecular biology and oncology. More particularly, this invention relates to the sensitization of cancerous cells to therapeutic agents. The invention provides methods, compositions, and formulations for potentiating or enhancing the toxicity of various cytotoxins and oxidizing agents, and of reducing the resistance and proliferation rate of cancer cells. It also provides various compositions and therapeutic formulations useful as anticancer agents.
    Type: Application
    Filed: April 3, 2001
    Publication date: March 9, 2006
    Inventors: Sudhir Agrawal, Ekambar Kandimalla, David Bregman, Sridhar Mani, Yi Lu
  • Patent number: 4111209
    Abstract: Apparatus and method for providing hypothermia or effecting hemostasis to prevent hemorrhaging in organs or regions of the human body and the like. In one application described herein, the apparatus provides hypothermia to the heart during, for example, cardio-pulmonary bypass. The apparatus comprises a unitary preferably disposable coolant fluid circuit, including a length of flexible tubing having a heat exchange portion and a flexible, inflatable bag through which a sterile coolant fluid passes. The inflatable bag is connected to the flexible tubing by a double lumen. The tubing is provided with appropriate fittings proximate to its juncture with the double lumen to allow introduction of coolant fluid. The heat exchanger portion of the coolant fluid circuit is located within a preferably disposable container which contains refrigeration means for reducing the temperature of the coolant fluid.
    Type: Grant
    Filed: April 18, 1977
    Date of Patent: September 5, 1978
    Assignee: Datascope Corporation
    Inventors: Sidney Wolvek, Bruce L. Hanson, David Bregman
  • Patent number: 4080958
    Abstract: Improved blood pumping apparatus is disclosed which includes a smooth avalvular deflatable section through which blood flows, said section mounted within a rigid avalvular airtight housing, gas being introduced and withdrawn from the housing by suitable control means, the action of the gas causing the blood chamber to inflate and deflate with consequent non-traumatic pulsatile ejection of blood from said chamber. The apparatus is simple, reliable, inexpensive and can aid the blood pumping function in many ways. For example, apparatus is disclosed to provide pulsatile flow to the blood being pumped by a heart-lung machine, or to provide pulsatile flow to the coronary arteries during coronary artery perfusion, or to be utilized as an arterio-venous fistula to decrease the afterload of the left ventricle and preserve the systemic diastolic pressure while increasing coronary perfusion.
    Type: Grant
    Filed: February 27, 1976
    Date of Patent: March 28, 1978
    Assignee: Datascope Corporation
    Inventors: David Bregman, Bruce L. Hanson, Sidney Wolvek