Patents by Inventor David Brett LUDWIG

David Brett LUDWIG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ROOM TEMPERATURE STABLE LYOPHILIZED PROTEIN
    Publication number: 20220257763
    Abstract: Stable lyophilized therapeutic protein compositions and their methods of manufacture are provided. Specifically, the use of water as a solid cake plasticizer and protein stabilizer is described. Also, the inclusion of a multicomponent stabilizer comprising a larger molecular entity and a smaller molecular entity is described. Also, the inclusion of post-drying annealing under certain conditions improves protein stability. Proteins are predicted to remain stable over 24 months at 25° C.
    Type: Application
    Filed: May 6, 2022
    Publication date: August 18, 2022
    Inventors: Xiaolin Tang, David Brett Ludwig
  • Room temperature stable lyophilized protein
    Patent number: 11351256
    Abstract: Stable lyophilized therapeutic protein compositions and their methods of manufacture are provided. Specifically, the use of water as a solid cake plasticizer and protein stabilizer is described. Also, the inclusion of a multicomponent stabilizer comprising a larger molecular entity and a smaller molecular entity is described. Also, the inclusion of post-drying annealing under certain conditions improves protein stability. Proteins are predicted to remain stable over 24 months at 25° C.
    Type: Grant
    Filed: October 6, 2017
    Date of Patent: June 7, 2022
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventors: Xiaolin Tang, David Brett Ludwig
  • Room temperature stable lyophilized protein
    Patent number: 11241498
    Abstract: Stable lyophilized therapeutic protein compositions and their methods of manufacture are provided. Specifically, the use of water as a solid cake plasticizer and protein stabilizer is described. Also, the inclusion of a multicomponent stabilizer comprising a larger molecular entity and a smaller molecular entity is described. Also, the inclusion of post-drying annealing under certain conditions improves protein stability. Proteins are predicted to remain stable over 24 months at 25° C.
    Type: Grant
    Filed: October 17, 2019
    Date of Patent: February 8, 2022
    Assignee: Regeneran Pharmaceuticals, Inc.
    Inventors: Xiaolin Tang, David Brett Ludwig
  • ROOM TEMPERATURE STABLE LYOPHILIZED PROTEIN
    Publication number: 20200046834
    Abstract: Stable lyophilized therapeutic protein compositions and their methods of manufacture are provided. Specifically, the use of water as a solid cake plasticizer and protein stabilizer is described. Also, the inclusion of a multicomponent stabilizer comprising a larger molecular entity and a smaller molecular entity is described. Also, the inclusion of post-drying annealing under certain conditions improves protein stability. Proteins are predicted to remain stable over 24 months at 25° C.
    Type: Application
    Filed: October 17, 2019
    Publication date: February 13, 2020
    Inventors: Xiaolin Tang, David Brett Ludwig
  • Stabilized Antibody Compositions and Methods of Producing Same
    Publication number: 20190021952
    Abstract: The present invention provides drug products comprising sealed containers containing a stable liquid recombinant protein, such as an antigen-binding protein, composition and a headspace gas comprising less than 5% oxygen, and methods of producing same. As such, the present invention provides a method for controlling the oxygen levels in the headspace of a drug product in a sealed container comprising a stable liquid recombinant protein composition and a headspace gas comprising less than 21% oxygen.
    Type: Application
    Filed: July 23, 2018
    Publication date: January 24, 2019
    Inventors: Xiaolin TANG, David Brett LUDWIG
  • Room Temperature Stable Lyophilized Protein
    Publication number: 20180099049
    Abstract: Stable lyophilized therapeutic protein compositions and their methods of manufacture are provided. Specifically, the use of water as a solid cake plasticizer and protein stabilizer is described. Also, the inclusion of a multicomponent stabilizer comprising a larger molecular entity and a smaller molecular entity is described. Also, the inclusion of post-drying annealing under certain conditions improves protein stability. Proteins are predicted to remain stable over 24 months at 25° C.
    Type: Application
    Filed: October 6, 2017
    Publication date: April 12, 2018
    Inventors: Xiaolin TANG, David Brett LUDWIG