Abstract: The perivascular leak repair system, and method of using the same, of the present invention provides a sealant reservoir with a repair catheter operably attached; a flow control device disposed between the sealant reservoir and the repair catheter, and the flow control device responsive to a flow control signal; a heart phase detector generating a diastole phase signal; an injection switch generating a injection signal; and a flow controller responsive to the diastole phase signal and the injection signal, and generating the flow control signal. A method of sealing a perivascular leak comprises identifying the perivascular leak; inserting a repair catheter to the perivascular leak; injecting sealant at the perivascular leak; and removing the repair catheter. The sealant can be injected when the heart is in diastole to sweep the sealant into the perivascular leak.

Abstract: A method to assemble a nozzle-fastener assembly including: inserting a hollow stem through a wash liquid direction device; inserting the hollow stem through a mounting block; positioning an inside surface of the mounting block against a curved surface of a wash liquid distribution pipe and an outside surface of the block against the wash liquid direction device; attaching the nozzle-fastener to an aperture in the pipe such that an inlet to the hollow stem is in fluid communication with a wash liquid passage in the pipe, wherein the stem extends through the mounting block and the wash liquid direction device, and the stem includes a outlet for the wash liquid passing through the hollow stem and to the wash liquid direction device, and wherein the wash liquid direction device and mounting block are held together by the attachment of the nozzle-fastener to the aperture in the wash liquid pipe.

Abstract: The perivascular leak repair system, and method of using the same, of the present invention provides a sealant reservoir 102 with a repair catheter 104 operably attached; a flow control device 106 disposed between the sealant reservoir 102 and the repair catheter 104, and the flow control device 106 responsive to a flow control signal 108; a heart phase detector 114 generating a diastole phase signal 112; an injection switch 122 generating a injection signal 120; and a flow controller 110 responsive to the diastole phase signal 112 and the injection signal 120, and generating the flow control signal 108. A method of sealing a perivascular leak comprises identifying the perivascular leak 140; inserting a repair catheter to the perivascular leak 142; injecting sealant at the perivascular leak 144; and removing the repair catheter 146. The sealant can be injected when the heart is in diastole to sweep the sealant into the perivascular leak.

Abstract: A method to assemble a nozzle-fastener assembly including: inserting a hollow stem through a wash liquid direction device; inserting the hollow stem through a mounting block; positioning an inside surface of the mounting block against a curved surface of a wash liquid distribution pipe and an outside surface of the block against the wash liquid direction device; attaching the nozzle-fastener to an aperture in the pipe such that an inlet to the hollow stem is in fluid communication with a wash liquid passage in the pipe, wherein the stem extends through the mounting block and the wash liquid direction device, and the stem includes a outlet for the wash liquid passing through the hollow stem and to the wash liquid direction device, and wherein the wash liquid direction device and mounting block are held together by the attachment of the nozzle-fastener to the aperture in the wash liquid pipe.

Abstract: A nozzle assembly for spraying a wash liquid towards a pulp mat, the assembly including an integral fastener-nozzle having a conduit for the wash liquid, an outlet to the conduit for discharging the wash liquid and an attachment to secure the fastener-nozzle to an aperture in a wash liquid pipe, and a wash liquid direction device extending outwardly from the pipe and adapted to direct the wash liquid from the outlet towards the pulp mat.

Abstract: Embodiments of the invention relate to electrophysiology catheters and methods of using the same. According to one embodiment, a method of treating a cardiac arrhythmia comprises forming a first lesion about a source of an electrical signal in the heart, the first lesion having an open first perimeter, and forming a second lesion about the source of the electrical signal in the heart. The second lesion has an open second perimeter and is located closer to the source of the electrical signal than the first lesion. The first lesion is discontinuous from the second lesion, and at least the first and second lesions together form a closed, at least substantially complete conduction block. According to other embodiments, catheters are provided for performing this and other methods.

Abstract: Methods of treating an aneurysm in a patient in need thereof are provided. The methods comprise delivering to a treatment site an effective amount of a fatty acid inhibitor of a matrix metalloproteinase (MMP) such that the fatty acid inhibitor of the MMP causes the regression of a pre-existing aneurysm. Additionally, an implantable medical device is provided for implanting in a vessel wall of a patient comprising a structural support and a fatty acid inhibitor of an MMP.

Abstract: A nozzle assembly for spraying a wash liquid towards a pulp mat, the assembly including an integral fastener-nozzle having a conduit for the wash liquid, an outlet to the conduit for discharging the wash liquid and an attachment to secure the fastener-nozzle to an aperture in a wash liquid pipe, and a wash liquid direction device extending outwardly from the pipe and adapted to direct the wash liquid from the outlet towards the pulp mat.

Abstract: A system, method, and computer program for interactive communication among a plurality of users. The invention, called Holocene Conversation Mode (“HCM”), takes advantage of the observation that human beings have developed or utilize a number of real-world characteristics to participate in, perceive, control, and glean subtleties from conversations. These characteristics include proximity and orientation of a listener to other speakers, memory ageing, emphasis by a speaker, relative importance of a speaker to a listener, reputation of a speaker, and the unique human ability to “filter” words of special interest to a listener from overheard conversations. HCM includes a suite of techniques, including spatial and content compression as a function of some of such characteristics, that can be implemented in various combinations in computer software.

Abstract: The present invention encompasses methods and apparatus for aiding aneurysm repair.

Abstract: Methods and apparatus for minimizing the risks inherent in endovascular grafting for aneurysm repair are provided, including the implantation and time-controlled release of at least one bioactive agent at the aneurysmal site.

Abstract: The present invention is a temporary intraluminal filter guidewire for use during interventional procedures, such as angioplasty or stent deployment. A braided filter is mounted near the distal end of a steerable guidewire, which guides a therapeutic catheter. An actuator rod slides over the guidewire and is removably connected to the filter. The rod controls relative displacement of the filter ends, causing transformation of the filter between a deployed configuration and a collapsed configuration. Wire having enhanced radiopacity is included in the filter to provide visualization under fluoroscopy.

Abstract: Methods and apparatus for aiding aneurysm repair are provided. Such apparatus is constructed to support or bolster the aneurysmal site initially, while contracting if the aneurysmal site shrinks or contracts. The apparatus also supplies a pharmaceutical agent to aid in healing the surrounding aneurysmal tissue. The apparatus may comprise a drug eluting polymer or may have a passive coating which can be selectively deployed by adding an activation agent after deployment. The device can be used alone or in conjunction with a AAA stent graft that isolates the aneurysmal sac from the vascular system.

Abstract: A novel system, method, and computer program for interactive communication among a plurality of users. The invention, called Holocene Conversation Mode (“HCM”), takes advantage of the observation that human beings have developed or utilize a number of real-world characteristics to participate in, perceive, control, and glean subtleties from conversations. These characteristics include proximity and orientation of a listener to other speakers, memory ageing, emphasis by a speaker, relative importance of a speaker to a listener, reputation of a speaker, and the unique human ability to “filter” words of special interest to a listener from overheard conversations. HCM includes a suite of techniques, including spatial and content compression as a function of some of such characteristics, that can be implemented in various combinations in computer software.