Abstract: An asymmetrical cutting tool has a partially cord-wrapped handle with a first handle panel, a second handle panel, and an intercheangeable overlay. The cutting tool further includes a folding blade, pivotably attached to the cord-wrapped/overlaid handle, and having a partially concave edge and a punch tip. The folding blade is operable to transition between a locked state and an unlocked state. Lock wear is compensated by dual eccentric thumb studs which act as a camshaft lobe to alter the position of the blade with respect to the lock while in the locked state. The partially cord-wrapped handle is configured to receive the folding blade when the blade transitions from the locked state into the unlocked state.

Abstract: An asymmetrical cutting tool has a partially cord-wrapped handle with a first handle panel, a second handle panel, and an intercheangeable overlay. The cutting tool further includes a folding blade, pivotably attached to the cord-wrapped/overlaid handle, and having a partially concave edge and a punch tip. The folding blade is operable to transition between a locked state and an unlocked state. Lock wear is compensated by dual eccentric thumb studs which act as a camshaft lobe to alter the position of the blade with respect to the lock while in the locked state. The partially cord-wrapped handle is configured to receive the folding blade when the blade transitions from the locked state into the unlocked state.

Abstract: A walking cane retention clip that provides convenient temporary placement of the cane so that the user can perform a two-handed task. The retention clip provides a garment clasping region for attachment to a garment such as a waistband, a belt or both. A mobility aid receiving region is used for releasably retaining a mobility aid such as a cane or walking staff. The retention clip comprises a unitary construction that is configured for vertical or horizontal retention of a mobility aid. The retention clip is fabricated from high strength materials that are capable of delivering long-term function without significant risk of wear or mechanical failure. The retention clip is configured and fabricated from materials that facilitate cleaning and sanitization of the retention clip.

Abstract: The present invention provides methods and systems for organizing complex and disparate data. More specifically, the present invention provides methods and systems for organizing complex and disparate data into coherent data sets. Coherent data sets resulting from the methods and systems of the present invention serve as models for biological systems. Methods and systems for integrating data and creating coherent data sets are useful for numerous biological applications, such as, for example, determining gene function, identifying and validating drug and pesticide targets, identifying and validating drug and pesticide candidate compounds, profiling drug and pesticide compounds, producing a compilation of health or wellness profiles, determining compound site(s) of action, identifying unknown samples, and numerous other applications in the agricultural, pharmaceutical, forensic, and biotechnology industries.

Abstract: The present invention provides methods and systems for organizing complex and disparate data. More specifically, the present invention provides methods and systems for organizing complex and disparate data into coherent data sets. Coherent data sets resulting from the methods and systems of the present invention serve as models for biological systems. Methods and systems for integrating data and creating coherent data sets are useful for numerous biological applications, such as, for example, determining gene function, identifying and validating drug and pesticide targets, identifying and validating drug and pesticide candidate compounds, profiling drug and pesticide compounds, producing a compilation of health or wellness profiles, determining compound site(s) of action, identifying unknown samples, and numerous other applications in the agricultural, pharmaceutical, forensic, and biotechnology industries.

Abstract: The present invention provides methods and systems for organizing complex and disparate data. More specifically, the present invention provides methods and systems for organizing complex and disparate data into coherent data sets. Coherent data sets resulting from the methods and systems of the present invention serve as models for biological systems. Methods and systems for integrating data and creating coherent data sets are useful for numerous biological applications, such as, for example, determining gene function, identifying and validating drug and pesticide targets, identifying and validating drug and pesticide candidate compounds, profiling drug and pesticide compounds, producing a compilation of health or wellness profiles, determining compound site(s) of action, identifying unknown samples, and numerous other applications in the agricultural, pharmaceutical, forensic, and biotechnology industries.

Abstract: The cloning of a truncated Arabidopsis gene expressing squalene synthase, as well as the expression and purification of the squalene synthase, are described. Also described herein is a fluorescent assay using squalene synthase that is amenable to high-throughout use, particularly for studying the regulation of isoprenoid synthesis and identifying squalene synthase inhibitors and promoters. As the formation of squalene is stoichiometric with the depletion of NADPH, the activity of squalene synthase can be evaluated by following the NADPH concentration over time. Squalene synthase activity is determined by combining FPP, NADPH, squalene synthase and a magnesium ion cofactor to form a reaction mixture under conditions suitable for squalene formation, optionally in the presence of a compound being analyzed for its ability to inhibit or promote squalene synthase. The concentration of NADPH over time is determined by subjecting the reaction mixture to UV light and detecting fluorescent light emission.