Abstract: The invention generally relates to VHH domains that specifically bind a severe acute respiratory syndrome coronavirus spike protein receptor binding domain, corresponding expression vectors and host cells, and methods of treatment using such VHH domains.

Abstract: Devices and methods of altering protein concentrations in cerebrospinal fluid and/or brain interstitial fluid are disclosed. Devices include a support having at least one protease attached to the support. The device may further include a housing. Devices may be implantable for use in an in vivo active flow system or for use in an in vivo passive system. Devices may also be used in an ex vivo active flow system. Devices may also be used in a passive system to treat cerebrospinal fluid and/or brain interstitial fluid that is withdrawn, or in a passive system that is implanted surgically. Methods include contacting cerebrospinal fluid and/or brain interstitial fluid with a support including at least one protease attached to the support. Proteins contained in the cerebrospinal fluid and/or brain interstitial fluid are cleaved by the protease resulting in the reduction of protein in cerebrospinal fluid and/or brain interstitial fluid.

Abstract: A retention treatment basin system and method 10 that handles an influent of combined wastewater and sewer overflows. The influent includes floatable 12 and settlable solids 14. The basin includes a ceiling 16. The retention treatment basin has one or more influent channels 20 that duct the influent into the basin. A weir assembly 22 extends upwardly from the floor, over which the influent flows. A cell 24 receives the influent passing over the weir. At least some of the settlable solids are retained in the cell. A baffle 26 traps at least some of the floatable solids in the cell. Part of the influent passes under the baffle. One or more up-flow screen systems 28 with bars having a triangular cross-section extend from the baffle that are pervious to fluids for receiving the influent and arresting movement of floatable solids therethrough. The screen system creates a floatable-solids depleted effluent.

Abstract: A retention treatment basin system and method 10 that handles an influent of combined wastewater and sewer overflows. The influent includes floatable 12 and settlable solids 14. The basin includes a ceiling 16. The retention treatment basin has one or more influent channels 20 that duct the influent into the basin. A weir assembly 22 extends upwardly from the floor, over which the influent flows. A cell 24 receives the influent passing over the weir. At least some of the settlable solids are retained in the cell. A baffle 26 traps at least some of the floatable solids in the cell. Part of the influent passes under the baffle. One or more up-flow screen systems 28 with bars having a triangular cross-section extend from the baffle that are pervious to fluids for receiving the influent and arresting movement of floatable solids therethrough. The screen system creates a floatable-solids depleted effluent.

Abstract: A dispenser for elongate thin flexible articles that are stacked within a cartridge package is comprised of a cartridge holder to be vertically positioned and having a front access door and interior projections whereby a cartridge may be placed in the holder with the door open and maintained in a predetermined vertical position within the holder after the door is closed. The cartridge is provided with an opening at its lower end and the holder is provided with an opening at its lower end shaped to prevent the removal of an article unless it is gripped and flexed to conform to the opening.