Abstract: The present disclosure provides methods for treating, preventing, ameliorates, inhibits, or delaying the onset of Leigh syndrome as well as methods for ameliorating, inhibiting, ameliorates, inhibits, or delaying the onset of its associated signs and/or symptoms, such as exercise-induced acid acidosis, and increases in plasma levels of growth factor 15 (GDF-15) and/or fibroblast growth factor (FGF-21) in a subject in need thereof comprising administering to the subject various compounds, mixtures of compounds or compositions, formulations or medicaments derived therefrom.

Abstract: Rechargeable electrochemical battery cells are disclosed. In particular, are disclosed discharge state assembled rechargeable electrochemical cells, which, when in discharged state, comprises an electrically conductive anodic current collector and a cathode that comprises metallic material as an active material.

Abstract: An electrode pad for electro-stimulation includes a first non-conductive flexible substrate, a primer, and a layer of conductive silicone. The first non-conductive flexible substrate includes at least one conductive track disposed on a first side of the first non-conductive flexible substrate. The primer is disposed on the first side of the first non-conductive flexible substrate in areas not covered by the at least one conductive track. The layer of conductive silicone is disposed over the at least one conductive track and the primer. The primer is bonding the first non-conductive flexible substrate to the layer of conductive silicone providing mechanical contact between the at least one conductive track and a first side of the layer of conductive silicone.

Abstract: Provided herein is a ribonucleic acid (RNA) encoding a spike (S) protein or an immunogenic fragment thereof of a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) comprising at least one non-naturally occurring amino acid mutation. In some embodiments, the S protein is derived from a delta variant. Additionally provided are relevant polynucleotides, vectors, cells, compositions, kits, production methods and methods of use.

Abstract: Provided herein is a ribonucleic acid (RNA) encoding a spike (S) protein or an immunogenic fragment thereof of a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) comprising at least one non-naturally occurring amino acid mutation. In some embodiments, the S protein is derived from an Omicron variant. Additionally provided are relevant polynucleotides, vectors, cells, compositions, kits, production methods and methods of use.

Abstract: A device may receive a downlink signal from a base station and may construct a frozen decode matrix for decoding frozen bits from data of the downlink signal. The device may construct a linear feedback shift register (LFSR) generator matrix for a component of scrambling sequence seed bits and may multiply the frozen decode matrix and the LFSR generator matrix to generate a mapping matrix for mapping a value of a scrambling sequence initialization vector that initializes a scrambler to the frozen bits. The device may determine an inverse matrix of the mapping matrix and may multiply the inverse matrix and the frozen decode matrix to obtain a final matrix. The device may utilize the final matrix to recover, from the data of the downlink signal, the scrambling sequence seed bits used to initialize the component and may perform actions based on the scrambling sequence seed bits.

Abstract: The present disclosure provides methods for treating, preventing, ameliorates, inhibits, or delaying the onset of Leigh syndrome as well as methods for ameliorating, inhibiting, ameliorates, inhibits, or delaying the onset of its associated signs and/or symptoms in a subject in need thereof comprising administering to the subject various compounds, mixtures of compounds or compositions, formulations or medicaments derived therefrom. The present disclosure further provides compositions, formulations or medicaments and related uses for the treatment, prevention ameliorating, inhibiting, or delaying the onset of Leigh syndrome in a subject and addressing its associated signs and/or symptoms.

Abstract: The disclosure provides methods for treating muscular dystrophy (MD), such as Duchenne muscular dystrophy (DMD) or Becker muscular dystrophy (BMD) in a mammalian subject. The methods comprise administering to the subject an effective amount of a peptide such as H-D-Arg-2,6-Dmt-Lys-PHe-NH2 (SEQ ID NO: 2) (a.k.a. MTP-131 or elamipretide), or a pharmaceutically acceptable salt, hydrate, solvate and/or tautomer thereof, in combination with at least one phosphorodiamidate morpholino oligomer (PMO) or peptide-conjugated PMO (PPMO). The methods are particularly useful for increasing dystrophin expression levels in subjects diagnosed with, and/or being treated for, MD in an amount greater than what would be possible by treatment with the PMO or PPMO alone.

Abstract: A faulty meter socket detection system configured to detect faulty sockets as evidenced by series arcs in an input current waveform or an increased temperature of the meter is disclosed. The system includes a metering circuit configured to receive an input current waveform, and a controller including a power monitoring module. The meter may also include a temperature sensor. The power monitoring module is configured detect series arc currents input current waveform data by filtering the input current waveform data to produce filtered data, performing feature recognition on the filtered data, classifying the features of the filtered data, performing temporal processing on the filtered data, (optionally) scaling the temporal processing of the filtered data, and, scoring the input current waveform based on the temporal processing of the filtered data. The temperature sensor may detect an increased temperature of the meter, which may indicate a faulty socket.

Abstract: A device may receive a downlink signal from a base station and may determine an input-output relation of polar encoding based on a vector of the downlink signal. The device may perform an interleaving operation with a matrix and the input-output relation to obtain an interleaved vector and may utilize rate matching with the interleaved vector to determine a scrambling sequence of the downlink signal. The device may utilize a reverse sequence generator with the scrambling sequence to determine a scrambling sequence initialization vector for the scrambling sequence and may perform one or more actions based on the scrambling sequence initialization vector.

Abstract: Implementations described herein relate to methods, systems, and computer-readable media to display a virtual character within a virtual environment on a display device. In some implementations, a method can include obtaining an input pose of the virtual character, wherein the virtual character is based on a rig that comprises a plurality of joints, receiving an indication of one or more of a position and an orientation of a target end effector located on the rig, determining an output pose for the rig wherein the determining comprises calculating a respective orientation and position of one or more joints of the plurality of joints of the rig based on the position of the target end effector and rotation constraints of a plurality of joints of a reference rig, and displaying the virtual character in the output pose on the display device.

Abstract: Exemplary embodiments of the disclosure may be drawn to a device having an inlet and a chamber. Immobilized lipase, immobilized protease, and immobilized amylase may be contained within the chamber. The device may also include an outlet, wherein a flow path extends from the inlet, through the chamber, and to the outlet.

Abstract: The present disclosure provides a combination therapy for treating, preventing, inhibiting, ameliorating, or delaying the onset of Friedreich's ataxia in a subject in need thereof comprising administering to the subject both elamipretide and omaveloxolone or pharmaceutically acceptable salts, stereoisomers, mixtures of stereoisomers, tautomers, hydrates, and/or solvates thereof. The present disclosure further provides an embodiment of a combination product suitable for administration to said subject.

Abstract: An embodiment of the invention describes a method for detecting tampering with copy restrictions on a media playback device that includes identifying locations within playback application executable files on a playback device that contain instructions for application programming interface (API) calls, modifying the API call locations to insert pieces of tamper detection code, where the pieces of tamper detection code when executed collects monitoring data about characteristics of the playback device and content being played, collecting monitoring data when API calls are performed by the API call locations, generating a confidence level of tampering from the collected monitoring data, and performing a remediation action in response to the confidence level exceeding a predetermined threshold, where the predetermined threshold is set based on types of monitoring data that was collected.

Abstract: A device may receive a downlink signal from a base station and may construct a frozen decode matrix for decoding frozen bits from data of the downlink signal. The device may construct a linear feedback shift register (LFSR) generator matrix for a component of scrambling sequence seed bits and may multiply the frozen decode matrix and the LFSR generator matrix to generate a mapping matrix for mapping a value of a scrambling sequence initialization vector that initializes a scrambler to the frozen bits. The device may determine an inverse matrix of the mapping matrix and may multiply the inverse matrix and the frozen decode matrix to obtain a final matrix. The device may utilize the final matrix to recover, from the data of the downlink signal, the scrambling sequence seed bits used to initialize the component and may perform actions based on the scrambling sequence seed bits.

Abstract: A device may receive a downlink signal from a base station and may determine an input-output relation of polar encoding based on a vector of the downlink signal. The device may perform an interleaving operation with a matrix and the input-output relation to obtain an interleaved vector and may utilize rate matching with the interleaved vector to determine a scrambling sequence of the downlink signal. The device may utilize a reverse sequence generator with the scrambling sequence to determine a scrambling sequence initialization vector for the scrambling sequence and may perform one or more actions based on the scrambling sequence initialization vector.

Abstract: The present invention relates to a composition comprising nitroxoline, or a pharmaceutically acceptable salt thereof, for use in the treatment or prevention of a plexiform neurofibroma.

Abstract: A surface cleaning head includes dual rotating agitators (e.g., a leading roller and a brush roll) and a removable cover for covering a top of the agitators and allowing access to the agitators from a top of the surface cleaning head. The dual agitators may be used to facilitate capturing of debris in the air flow into a suction conduit on the underside of the surface cleaning head. The brush roll may be located in a brush roll chamber and at least partially in an opening to the suction conduit. The leading roller may be positioned adjacent to and in advance of the suction conduit opening such that the leading roller engages debris and moves the debris toward the brush roll and the opening. The leading roller may be removable from the housing and held in place by the removable cover. The cover may be coupled using isolated latching mechanisms.

Abstract: Compositions and methods are provided for potent mRNA vaccines for treatment of cancer with mutations in ras gene family multiplexed with TP53. The compositions include a pharmaceutical composition containing mRNA molecules encoding multiple peptides of a group of somatic mutations together with a pharmaceutically acceptable carrier. Methods for stimulating system immune responses and treatment are provided, including intratumoral, intravenous, intramuscular, intradermal, and subcutaneous injection.