Patents by Inventor David Bruce Lackey

David Bruce Lackey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Enzymatic synthesis of oligonucleotides using digestible templates
    Patent number: 5932450
    Abstract: The present invention describes methods of synthesizing oligonucleotides. In particular, it relates to methods of enzymatically synthesizing chirally pure oligonucleotides using templates which can be digested after synthesis. By using digestible templates, separation and purification of the synthesized oligonucleotides are greatly facilitated.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: August 3, 1999
    Assignee: Gen-Probe Incorporated
    Inventors: Nanibhushan Dattagupta, Daniel L. Kacian, David Bruce Lackey
  • Enzymatic synthesis of oligonucleotides using 3'-ribonucleotide primers
    Patent number: 5916777
    Abstract: The present invention relates to methods of enzymatically synthesizing oligonucleotides. In particular, it relates to the use of 3'-ribonucleotide primers which effectively serve to initiate oligonucleotide synthesis, and can also be easily cleaved from synthesis products and reused in subsequent synthesis reactions.
    Type: Grant
    Filed: October 10, 1997
    Date of Patent: June 29, 1999
    Assignee: Gen-Probe Incorporated
    Inventors: Daniel Louis Kacian, Nanibhushan Dattagupta, David Bruce Lackey
  • Enzymatic synthesis of phosphorothioate oligonucleotides using restriction endonucleases
    Patent number: 5739311
    Abstract: The present invention relates to methods of synthesizing phosphorothioate oligonucleotides. In particular, it relates to the use of certain restriction endonucleases to cleave phosphorothioate oligonucleotides which contain restriction endonuclease recognition sequences. These restriction sequences facilitate the cleavage of relatively cleavage resistant phosphorothioate oligonucleotides thus facilitating their separation and purification after synthesis.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: April 14, 1998
    Assignee: Gen-Probe Incorporated
    Inventors: David Bruce Lackey, Nanibhushan Dattagupta, Daniel Louis Kacian
  • Use of restriction endonuclease sequences for cleaving phosphorothioate oligonucleotides
    Patent number: 5652126
    Abstract: The present invention relates to methods of cleaving phosphorothioate oligonucleotides. In particular, it relates to the use of certain restriction endonucleases to cleave phosphorothioate oligonucleotides which contain restriction endonuclease recognition sequences. These restriction sequences can be used to facilitate the cleavage of relatively cleavage resistant phosphorothioate oligonucleotides thus facilitating their separation and purification after synthesis.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: July 29, 1997
    Assignee: Gen-Probe Incorporated
    Inventors: David Bruce Lackey, Nanibhushan Dattagupta, Daniel Louis Kacian