Patents by Inventor David Brzozowski

David Brzozowski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ENZYMATIC AMMONOLYSIS PROCESS FOR THE PREPARATION OF INTERMEDIATES FOR DPP IV INHIBITORS
    Publication number: 20070207527
    Abstract: An enzymatic ammonolysis process is provided for the preparation of intermediates used in preparing dipeptidyl peptidase IV inhibitors wherein the enzyme Candida antarctica lipase-B is used to catalyze the ammonolysis process.
    Type: Application
    Filed: April 18, 2007
    Publication date: September 6, 2007
    Inventors: Ramesh Patel, Ronald Hanson, Iqbal Gill, David Brzozowski, Paul Skonezny, Michael Politino, Jason Chen, Francisco Moris-Varas, Brenda White
  • Enzymatic ammonolysis process for the preparation of intermediates for DPP IV inhibitors
    Publication number: 20050256019
    Abstract: An enzymatic ammonolysis process is provided for the preparation of intermediates used in preparing dipeptidyl peptidase IV inhibitors wherein the enzyme Candida antarctica lipase-B is used to catalyze the ammonolysis process.
    Type: Application
    Filed: May 2, 2005
    Publication date: November 17, 2005
    Inventors: Ramesh Patel, Ronald Hanson, Iqbal Gill, David Brzozowski, Paul Skonezny, Michael Politino, Jason Chen, Francisco Moris-Varas, Brenda White
  • Method for the preparation of fused heterocyclic succinimide compounds and analogs thereof
    Patent number: 6953679
    Abstract: Fused cyclic compounds, methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds.
    Type: Grant
    Filed: December 19, 2001
    Date of Patent: October 11, 2005
    Assignee: Bristol-Myers Squibb Company
    Inventors: Mark E. Salvati, Toomas Mitt, Ramesh N. Patel, Ronald L. Hanson, David Brzozowski, Animesh Goswami, Linda Nga Hoong Chu, Wen-sen Li, James H. Simpson, Michael J. Totleben, Weixuan He
  • METHOD FOR THE PREPARATION OF FUSED HETEROCYCLIC SUCCINIMIDE COMPOUNDS AND ANALOGS THEREOF
    Publication number: 20050119228
    Abstract: Fused cyclic compounds, methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds.
    Type: Application
    Filed: December 19, 2001
    Publication date: June 2, 2005
    Inventors: Mark Salvati, Toomas Mitt, Ramesh Patel, Ronald Hanson, David Brzozowski, Animesh Goswami, Linda Chu, Wen-sen Li, James Simpson, Michael Totleben, Weixuan He
  • Methods and compounds for producing dipeptidyl peptidase IV inhibitors and intermediates thereof
    Publication number: 20050090539
    Abstract: Methods and compounds for production of cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV are provided.
    Type: Application
    Filed: November 18, 2003
    Publication date: April 28, 2005
    Inventors: Truc Vu, David Brzozowski, Rita Fox, Jollie Godfrey, Ronald Hanson, Sergei Kolotuchin, John Mazzullo, Ramesh Patel, Jianji Wang, Kwok Wong, Jurong Yu, Jason Zhu, David Magnin, David Augeri, Lawrence Hamann
  • Enzymatic deprotection of amines and hydroxides
    Patent number: 6828119
    Abstract: Provided is a method of deprotecting a hydroxide or amine protected with a group of formula ArC*(R)H—(CH2)n—O—C(═O)— where the substituents are as described below, the method comprising: contacting the protected hydroxide or amine with an enzyme effective to remove the protecting group; and recovering the amine. Also provided is a method of isolating a bacteria producing an enzyme effective to remove a protecting group comprising: growing prospective bacteria on a medium having a growth selective amount of an amine compound that is protected as above; and isolating bacteria that grow on said medium.
    Type: Grant
    Filed: December 14, 2001
    Date of Patent: December 7, 2004
    Assignee: Bristol Myers Squibb Company
    Inventors: Ramesh Patel, David Brzozowski, Venkata Nanduri
  • Enzymatic deprotection of amines and hydroxides
    Publication number: 20020123110
    Abstract: Provided is a method of deprotecting a hydroxide or amine protected with a group of formula
    Type: Application
    Filed: December 14, 2001
    Publication date: September 5, 2002
    Inventors: Ramesh Patel, David Brzozowski, Venkata Nanduri
  • Method of chiral epoxidation of benzopyran or pyranopyridine derivatives using microorganisms
    Patent number: 5478734
    Abstract: An enzymatic process for the preparation of chiral epoxides, monohydroxy or dihydroxy compounds of formula ##STR1## by the stereoselective epoxidation or hydroxylation of benzopyrans of formula ##STR2## or resolution of compounds of formula ##STR3## The compounds of formula I and II are intermediates useful in the preparation of pyranyl cyanoguanidine derivatives.
    Type: Grant
    Filed: February 7, 1994
    Date of Patent: December 26, 1995
    Assignee: Bristol-Myers Squibb Company
    Inventors: Ramesh N. Patel, Amit Banerjee, Clyde McNamee, David Brzozowski, Laszlo J. Szarka