Patents by Inventor David C. Billington

David C. Billington has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Barbituric acid analogs as therapeutic agents
    Publication number: 20030229108
    Abstract: This invention pertains to active barbituric acid analogs which inhibit HIF-1 activity (e.g., the interaction between HIF-1&agr; and p300) and thereby inhibit angiogenesis, tumorigensis, and proliferative conditions, such as cancer. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit HIF-1 activity, and to inhibit angiogensis, tumorigensis, and proliferative conditions, such as cancer.
    Type: Application
    Filed: May 21, 2003
    Publication date: December 11, 2003
    Inventors: Jackie Y De Belin, Maria-Rosario Romero-Martin, Paul W Finn, Lee G Sayers, Norman M Law, David C Billington, Stephen Ryley, Shoumo Bhattacharya
  • Spirocyclic antipsychotic agents
    Patent number: 5324733
    Abstract: A class of spirocyclic piperidine derivatives are selective ligands at sigma recognition sites and are therefore useful in the treatment and/or prevention of psychiatric disorders. The claimed compounds are of the formula ##STR1## wherein, A and B are hydrogen, Q is a bond, R.sup.11, R.sup.12, and R.sup.13 are as defined in the specification.
    Type: Grant
    Filed: April 22, 1993
    Date of Patent: June 28, 1994
    Assignee: Merck Sharpe & Dohme Ltd.
    Inventors: David C. Billington, Mark S. Chambers
  • Octahydrobenzisoquinoline derivatives as antipsychotic agents
    Patent number: 5294618
    Abstract: A class of 1,2,3,4,4a,5,6,10b-octahydrobenz[f]isoquinoline compounds and pharmaceutically acceptable salts of formula I: ##STR1## wherein, R.sup.1 represents hydrocarbon;R.sup.2 and R.sup.3 independently represent hydrogen, hydrocarbon, halogen, cyano, trifluoromethyl, nitro, --OR.sup.x, --SR.sup.x, --NR.sup.x R.sup.y, --CO.sub.2 R.sup.x or together represent methylenedioxy; andR.sup.x and R.sup.y independently represent hydrogen or hydrocarbon.The compounds disclosed herein are selective ligands at sigma recognition sites and are therefore useful in the treatment of psychiatric disorders.
    Type: Grant
    Filed: February 11, 1993
    Date of Patent: March 15, 1994
    Assignee: Merck Sharp & Dohme Limited
    Inventors: David C. Billington, Michael G. N. Russell
  • Tricyclic antipsychotic agents
    Patent number: 5254561
    Abstract: A class of 2,3,4,4a,9,9a-hexahydro-1H-indeno[2,1-c]pyridine and 2,3,4,4a,5,6,7,11b-octahydro-1H-benzo[3,4]cyclohepta[1,2-c]pyridine derivatives are selective ligands at sigma recognition sites and are therefore useful in the treatment and/or prevention of psychiatric and/or gastrointestinal disorders.
    Type: Grant
    Filed: June 18, 1991
    Date of Patent: October 19, 1993
    Assignee: Merck Sharp & Dohme Limited
    Inventors: David C. Billington, Michael G. N. Russell
  • Spirocyclic antipsychotic agents
    Patent number: 5219860
    Abstract: A class of spirocyclic piperidine derivatives are selective ligands at sigma recognition sites and are therefore useful in the treatment and/or prevention of psychiatric disorders.
    Type: Grant
    Filed: March 1, 1991
    Date of Patent: June 15, 1993
    Assignee: Merck Sharp & Dohme Limited
    Inventors: Mark S. Chambers, David C. Billington
  • Synthesis of inositol phosphates
    Patent number: 5055597
    Abstract: This invention provides the 4-mono-anion of myo-inositol orthoformate, and describes a process for preparing this anion as well as the use of this anion in the preparation of a variety of mono- and poly-phosphate derivatives of myo-inositol.
    Type: Grant
    Filed: January 8, 1990
    Date of Patent: October 8, 1991
    Assignee: Merck Sharp & Dohme Ltd.
    Inventor: David C. Billington
  • Myo-inositol orthoformates
    Patent number: 4906761
    Abstract: This invention provides the 4-mono-anion of myo-inositol orthoformate, and describes a process for preparing this anion as well as the use of this anion in the preparation of a variety of mono- and poly-phosphate derivatives of myo-inositol.
    Type: Grant
    Filed: June 28, 1988
    Date of Patent: March 6, 1990
    Assignee: Merck Sharpe & Dohme Ltd.
    Inventor: David C. Billington