Abstract: An oral care composition is provided and includes a natural flavor extract, a sulfur source such as dimethyl disulfide, a stannous ion source, and a soluble metal ion source that prevents the formation of methyl mercaptan. The natural flavor extract may contain dimethyl disulfide as an impurity. The soluble metal ion source may include a metal salt, a metal oxide, or a combination thereof, and the soluble metal ion source may include a copper ion source, a silver ion source, a zinc ion source, or combinations thereof.

Abstract: An oral care composition is provided and includes hops acid, a tin ion source, a sulfur source, and a soluble metal salt that prevents the formation of methyl mercaptan. The soluble metal salt may include a copper salt, a silver salt, a zinc salt, or combinations thereof. The hops acid may be from a hops extract. The sulfur source may be an impurity, and the soluble metal salt may prevent the formation of unacceptable off-notes, which may be produced in the composition under reducing conditions.

Abstract: The disclosure provides compositions including ultrafine bubbles. The ultrafine bubbles may include water and gases released from solution in the water. The compositions may also include at least one non-gaseous solute. The ultrafine bubbles of the compositions may dissolve, surround, and/or stabilize one or more non-gaseous solutes. Methods of making and using the compositions for agricultural applications are also provided.

Abstract: The disclosure provides compositions comprising water and ultrafine bubbles, and optionally non-gaseous solutes. The disclosure also provides methods of making and using such compositions.

Abstract: The disclosure provides compositions including ultrafine bubbles having water and gases released from solution in the water that dissolve, surround, and/or stabilize one or more non-gaseous solutes and/or gaseous solutes, as well as methods of making and using the compositions for consumer products and applications, such as beverages, oral care solutions, food products, skin care products, and hair care products. The methods of making the compositions including ultrafine bubbles include processes for dissolving, surrounding, and/or stabilizing non-gaseous solutes and/or gaseous solutes with ultrafine bubbles.

Abstract: The disclosure provides compositions including ultrafine bubbles having water and gases released from solution in the water. The compositions may dissolve, surround, and/or stabilize one or more non-gaseous solutes. Methods of making and using the compositions for delivering an active pharmaceutical ingredient to cells are also provided. The methods of making the compositions including ultrafine bubbles include processes for dissolving, surrounding, and/or stabilizing non-gaseous solutes and/or active pharmaceutical ingredients with ultrafine bubbles. Methods of using the compositions to produce active pharmaceutical ingredients and/or increase yield thereof via fermentation are also provided.

Abstract: A method of imparting to, or modifying in, a comestible product, umami taste, including the addition to a comestible product base of at least one compound of formula (I) wherein one of X1, X2, or X3 is selected from the group consisting of S, N and O and the remaining two are CH2; and A is selected from in which R1, R2, R3, R4 R5, R6 are independently selected from the group consisting of H, methyl, ethyl, propyl, OH, OMe, OEt, COOH, COOR7, in which R7 is selected from linear or branched C1-C7 alkyl, and CONR8R9, in which R8 and R9 are independently selected from hydrogen and straight or branched C1-C4 alkyl; or any two adjacent substituents R2-R6 together form a ring of 5 or 6 members; and n is 1 or 0.

Abstract: A method of imparting to, or modifying in, a comestible product, umami taste, including the addition to a comestible product base of at least one compound of formula (I) wherein one of X1, X2, or X3 is selected from the group consisting of S, N and O and the remaining two are CH2; and A is selected from in which R1, R2, R3, R4 R5, R6 are independently selected from the group consisting of H, methyl, ethyl, propyl, OH, OMe, OEt, COOH, COOR7, in which R7 is selected from linear or branched C1-C7 alkyl, and CONR8R9, in which R8 and R9 are independently selected from hydrogen and straight or branched C1-C4 alkyl; or any two adjacent substituents R2-R6 together form a ring of 5 or 6 members; and n is 1 or 0.

Abstract: A method of modifying the taste of a consumable, comprising adding to a consumable base at least one compound of the formula I in which (a) A is selected from the moieties (b) n is from 0-7, such that X is absent or a linear alkylene group in which n is from 1-7; and (c) Z is absent and Y is a moiety selected from the groups —CHO, or —CH2OH; or (d) Z is present and is a C1-7 linear alkane, and Y is selected from —CHOH, —CO, or —COC(CH3)O. The result is a consumable with enhanced mouthfeel and/or creaminess.

Abstract: The present invention generally relates to a series of compounds, to pharmaceutical compositions containing the compounds, and to use of the compounds and compositions as therapeutic agents. More specifically, compounds of the present invention are thiophenyl and pyrrolyl azepine compounds. These compounds are serotonin receptor (5-HT2c) ligands and are useful for treating diseases, disorders, and conditions wherein modulation of the activity of serotonin receptors (5-HT2c) is desired (e.g. addiction, anxiety, depression, obesity, and others).

Abstract: The present invention generally relates to a series of compounds, to pharmaceutical compositions containing the compounds, and to use of the compounds and compositions as therapeutic agents. More specifically, compounds of the present invention are thiophenyl and pyrrolyl azepine compounds. These compounds are serotonin receptor (5-HT2c) ligands and are useful for treating diseases, disorders, and conditions wherein modulation of the activity of serotonin receptors (5-HT2c) is desired (e.g. addiction, anxiety, depression, obesity, and others).

Abstract: A method of modifying the taste of a consumable, comprising adding to a consumable base at least one compound of the formula I in which (a) A is selected from the moieties (b) n is from 0-7, such that X is absent or a linear alkylene group in which n is from 1-7; and (c) Z is absent and Y is a moiety selected from the groups —CHO, or —CH2OH; or (d) Z is present and is a C1-7 linear alkane, and Y is selected from —CHOH, —CO, or —COC(CH3)O. The result is a consumable with enhanced mouthfeel and/or creaminess.

Abstract: A method of providing a cooling sensation to the skin or the mucous membranes of the body, comprising the application thereto of at least one compound of the Formula I in which X is selected from S and O, R1 is selected from H and OMe, R2 is selected from OH, OMe and OEt, and R3 is selected from H and OH. Some of the compounds provide simultaneously cooling and sweetening effects.

Abstract: Organic compounds of formula (I), wherein: X is C, R1 to R6 may be independently selected from the group consisting of, H, C1-C3 alkyl, Br, F, Cl, R7 is O R8 is NH R9 is a group having 5 to 12 carbons selected from the group consisting of cycloalkyl or substituted alkyl, wherein the substituent is selected from the group consisting of aryl or cycloalkyl. The compounds create/modify flavour, in particular sweet flavour and may be used in compositions and consumable products.

Abstract: A method of masking a bitter aftertaste experienced in the consumption of a consumable composition, including the addition to the composition of a masking quantity of choline chloride. The proportion required is considerably less than the proportion of choline chloride used as a dietary supplement.

Abstract: Use of 2-methoxy-5-(phenoxymethyl)phenol to create or modify the sweetness of consumable products. This compound may be used in methods to create or modify the sweetness of consumable products.

Abstract: Organic compounds of formula (I) wherein: X is N, or C, R1-R6 may be independently selected from the group consisting of, H, substituted, unsubstituted, branched or unbranched C1-C4 alkyl, methoxy, ethoxy, Br, F, Cl, provided that when X is nitrogen there is no substituent at R6 Y is an alkylene group of the formula (CR7R8)m wherein R7 and R8 may be independently selected from the group consisting of hydrogen, substituted, unsubstituted, branched or unbranched C1-C4 alkylene, and m is an integer selected from 1 to 6. The compounds create or modify flavour, in particular sweet flavour and may be used in compositions and consumable products.

Abstract: The present invention generally relates to a series of compounds, to pharmaceutical compositions containing the compounds, and to use of the compounds and compositions as therapeutic agents. More specifically, compounds of the present invention are hexahydroazepinoindole and octahydroazepinoindole compounds. These compounds are serotonin receptor (5-HT) ligands and are useful for treating diseases, disorders, and conditions wherein modulation of the activity of serotonin receptors (5-HT) is desired (e.g. anxiety, depression and obesity).

Abstract: Acrylic n-hydroxy imides and their use in pharmaceutical compositions and in the inhibition of flap endonuclease are disclosed.

Abstract: The present invention generally relates to a series of compounds, to pharmaceutical compositions containing the compounds, and to use of the compounds and compositions as therapeutic agents. More specifically, compounds of the present invention are thiophenyl and pyrrolyl azepine compounds. These compounds are serotonin receptor (5-HT2c) ligands and are useful for treating diseases, disorders, and conditions wherein modulation of the activity of serotonin receptors (5-HT2c) is desired (e.g. addiction, anxiety, depression, obesity, and others).