Patents by Inventor David C. Bomberger
David C. Bomberger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20090032468Abstract: This invention is directed to systems and methods for removing lipids from a fluid, such as plasma, or from lipid-containing organisms. These systems contact a fluid with an extraction solvent, which causes the lipids in the fluid to separate from the fluid or causes lipids in the lipid-containing organisms to separate from the lipid-containing organism, using at least one hollow fiber contactor. The separated lipids are removed from the fluid. The extraction solvent is removed from the fluid or at least reduced to a level below a particular threshold enabling the fluid to be administered to a patient without the patient experiencing undesirable consequences. Once the fluid has been processed, the fluid may be administered to a patient who donated the fluid, to a different patient, or be stored.Type: ApplicationFiled: October 8, 2007Publication date: February 5, 2009Applicant: Lipid Sciences, Inc.Inventors: David C. Bomberger, Pablo E. Garcia, Eric Hegwer, Thomas P. Low, Ripudaman Malhotra
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Publication number: 20080203022Abstract: This invention is directed to systems and methods for removing lipids from a fluid or from lipid-containing organisms from a fluid, such as plasma. These systems combine a fluid with at least one extraction solvent, which causes the lipids to separate from the fluid or from the lipid-containing organisms. The separated lipids are removed from the fluid. The at least one extraction solvent is removed from the fluid or at least reduced to a concentration enabling the fluid to be administered to a patient without undesirable consequences. Once the fluid has been processed, the fluid may be administered to a patient who donated the fluid or to a different patient for therapy.Type: ApplicationFiled: May 5, 2008Publication date: August 28, 2008Applicant: Lipid Sciences, Inc.Inventors: David C. Bomberger, Bryan Chavez, Pablo E. Garcia, Eric Hegwer, Thomas P. Low, Ripudaman Malhotra, Jeffrey J. Shimon
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Patent number: 7402246Abstract: This invention is directed to systems and methods for removing lipids from a fluid or from lipid-containing organisms from a fluid, such as plasma. These systems combine a fluid with at least one extraction solvent, which causes the lipids to separate from the fluid or from the lipid-containing organisms. The separated lipids are removed from the fluid. The at least one extraction solvent is removed from the fluid or at least reduced to a concentration enabling the fluid to be administered to a patient without undesirable consequences. Once the fluid has been processed, the fluid may be administered to a patient who donated the fluid or to a different patient for therapy.Type: GrantFiled: June 28, 2007Date of Patent: July 22, 2008Assignee: Lipid Sciences, Inc.Inventors: David C. Bomberger, Bryan Chavez, Pablo E. Garcia, Eric Hegwer, Thomas P. Low, Ripudaman Malhotra, Jeffrey J. Shimon
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Publication number: 20080149572Abstract: This invention is directed to systems and methods for removing lipids from a fluid or from lipid-containing organisms from a fluid, such as plasma. These systems combine a fluid with at least one extraction solvent, which causes the lipids to separate from the fluid or from the lipid-containing organisms. The separated lipids are removed from the fluid. The at least one extraction solvent is removed from the fluid or at least reduced to a concentration enabling the fluid to be administered to a patient without undesirable consequences. Once the fluid has been processed, the fluid may be administered to a patient who donated the fluid or to a different patient for therapy.Type: ApplicationFiled: February 29, 2008Publication date: June 26, 2008Applicant: Lipid Sciences, Inc.Inventors: David C. Bomberger, Bryan Chavez, Pablo E. Garcia, Eric Hegwer, Thomas P. Low, Ripudaman Malhotra, Jeffrey J. Shimon
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Patent number: 7364658Abstract: This invention is directed to systems and methods for removing lipids from a fluid or from lipid-containing organisms from a fluid, such as plasma. These systems combine a fluid with at least one extraction solvent, which causes the lipids to separate from the fluid or from the lipid-containing organisms. The separated lipids are removed from the fluid. The at least one extraction solvent is removed from the fluid or at least reduced to a concentration enabling the fluid to be administered to a patient without undesirable consequences. Once the fluid has been processed, the fluid may be administered to a patient who donated the fluid or to a different patient for therapy.Type: GrantFiled: April 20, 2007Date of Patent: April 29, 2008Assignee: Lipid Sciences, Inc.Inventors: David C. Bomberger, Bryan Chavez, Pablo E. Garcia, Eric Hegwer, Thomas P. Low, Ripudaman Malhotra, Jeffrey J. Shimon
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Patent number: 7297261Abstract: Systems and methods for removing lipids from a fluid, such as plasma, or from lipid-containing organisms. A fluid is combined with at least one extraction solvent, which causes the lipids to separate from the fluid or from lipid-containing organisms. The separated lipids are removed from the fluid. The extraction solvent is removed from the fluid or at least reduced to an acceptable concentration enabling the delipidated fluid to be administered to a patient without the patient experiencing undesirable consequences. Once the fluid has been processed, the fluid may be administered to a patient who donated the fluid, to a different patient, or stored for later use.Type: GrantFiled: January 31, 2007Date of Patent: November 20, 2007Assignee: Lipid Sciences, Inc.Inventors: David C. Bomberger, Bryan Chavez, Pablo E. Garcia, Eric Hegwer, Thomas P. Low, Ripudaman Malhotra, Jeffrey J. Shimon
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Patent number: 7297262Abstract: This invention is directed to systems and methods for removing lipids from a fluid, such as plasma, or from lipid-containing organisms. These systems contact a fluid with an extraction solvent, which causes the lipids in the fluid to separate from the fluid or causes lipids in the lipid-containing organisms to separate from the lipid-containing organism, using at least one hollow fiber contactor. The separated lipids are removed from the fluid. The extraction solvent is removed from the fluid or at least reduced to a level below a particular threshold enabling the fluid to be administered to a patient without the patient experiencing undesirable consequences. Once the fluid has been processed, the fluid may be administered to a patient who donated the fluid, to a different patient, or be stored.Type: GrantFiled: October 30, 2006Date of Patent: November 20, 2007Assignee: Lipid Sciences, Inc.Inventors: David C. Bomberger, Pablo E. Garcia, Eric Hegwer, Thomas P. Low, Ripudaman Malhotra
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Patent number: 7195710Abstract: This invention is directed to systems and methods for removing lipids from a fluid or from lipid-containing organisms from a fluid, such as plasma. These systems combine a fluid with at least one extraction solvent, which causes the lipids to separate from the fluid or from the lipid-containing organisms. The separated lipids are removed from the fluid. The at least one extraction solvent is removed from the fluid or at least reduced to a concentration enabling the fluid to be administered to a patient without undesirable consequences. Once the fluid has been processed, the fluid may be administered to a patient who donated the fluid or to a different patient for therapy.Type: GrantFiled: May 28, 2004Date of Patent: March 27, 2007Assignee: Lipid Sciences, Inc.Inventors: David C. Bomberger, Bryan Chavez, Pablo E. Garcia, Eric Hegwer, Thomas P. Low, Ripudaman Malhotra, Jeffrey J. Shimon
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Patent number: 7166223Abstract: This invention is directed to systems and methods for removing lipids from a fluid, such as plasma, or from lipid-containing organisms. These systems contact a fluid with an extraction solvent, which causes the lipids in the fluid to separate from the fluid or causes lipids in the lipid-containing organisms to separate from the lipid-containing organism, using at least one hollow fiber contactor. The separated lipids are removed from the fluid. The extraction solvent is removed from the fluid or at least reduced to a level below a particular threshold enabling the fluid to be administered to a patient without the patient experiencing undesirable consequences. Once the fluid has been processed, the fluid may be administered to a patient who donated the fluid, to a different patient, or be stored.Type: GrantFiled: September 8, 2005Date of Patent: January 23, 2007Assignee: Lipid Sciences, Inc.Inventors: David C. Bomberger, Pablo E. Garcia, Eric Hegwer, Thomas P. Low, Ripudaman Malhotra
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Patent number: 7087245Abstract: Method and system of producing microparticles loaded with biologically active drugs, including proteins such as ICAM-1, for controlled release of the drugs in a nasal passageway. The method includes introducing a drug/polymer feed solution and an emulsifier into a first mixing chamber to create an emulsion, then mixing a cross-linking agent together with the emulsion under controlled conditions to create microparticles loaded with the drug. The system includes a first mixing chamber, in which the emulsion is created, having a first port for introducing the drug/polymer solution, and a second port angled substantially perpendicular to the first port for introducing the emulsifier. A second mixing chamber adjacent to the first mixing chamber receives the emulsion and either contains a cross-linking agent or receives a stream of a cross-linking agent to solidify the microparticles.Type: GrantFiled: April 22, 2002Date of Patent: August 8, 2006Inventors: David C. Bomberger, Paul G. Catz, Mark I. Smedley, Paul C. Stearns
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Patent number: 7033500Abstract: This invention is directed to systems and methods for removing lipids from a fluid or from lipid-containing organisms from a fluid, such as plasma. These systems combine a fluid with at least one extraction solvent, which causes the lipids to separate from the fluid or from the lipid-containing organisms. The separated lipids are removed from the fluid. The at least one extraction solvent is removed from the fluid or at least reduced to a concentration enabling the fluid to be administered to a patient without undesirable consequences. Once the fluid has been processed, the fluid may be administered to a patient who donated the fluid or to a different patient for therapy.Type: GrantFiled: June 21, 2002Date of Patent: April 25, 2006Assignee: Lipid Sciences, Inc.Inventors: David C. Bomberger, Bryan Chavez, Pablo E. Garcia, Eric Hegwer, Thomas P. Low, Ripudaman Malhotra, Jeffrey J. Shimon
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Patent number: 6991727Abstract: This invention is directed to systems and methods for removing lipids from a fluid, such as plasma, or from lipid-containing organisms. These systems contact a fluid with an extraction solvent, which causes the lipids in the fluid to separate from the fluid or causes lipids in the lipid-containing organisms to separate from the lipid-containing organism, using at least one hollow fiber contactor. The separated lipids are removed from the fluid. The extraction solvent is removed from the fluid or at least reduced to a level below a particular threshold enabling the fluid to be administered to a patient without the patient experiencing undesirable consequences. Once the fluid has been processed, the fluid may be administered to a patient who donated the fluid, to a different patient, or be stored.Type: GrantFiled: February 16, 2005Date of Patent: January 31, 2006Assignee: Lipid Sciences, Inc.Inventors: David C. Bomberger, Pablo E. Garcia, Eric Hegwer, Thomas P. Low, Ripudaman Malhotra
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Publication number: 20040256307Abstract: This invention is directed to systems and methods for removing lipids from a fluid or from lipid-containing organisms from a fluid, such as plasma. These systems combine a fluid with at least one extraction solvent, which causes the lipids to separate from the fluid or from the lipid-containing organisms. The separated lipids are removed from the fluid. The at least one extraction solvent is removed from the fluid or at least reduced to a concentration enabling the fluid to be administered to a patient without undesirable consequences. Once the fluid has been processed, the fluid may be administered to a patient who donated the fluid or to a different patient for therapy.Type: ApplicationFiled: May 28, 2004Publication date: December 23, 2004Inventors: David C. Bomberger, Bryan Chavez, Pablo E. Garcia, Eric Hegwer, Thomas P. Low, Ripudaman Malhotra, Jeffrey J. Shimon
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Patent number: 6833478Abstract: A method is provided for enhancing the solubility of an ionizable compound in a lipophilic medium by admixing the compound with an effective solubility-enhancing amount of an N,N-dinitramide salt. The ionizable compound, upon ionization, gives rise to a biologically active cationic species that ionically associates with the N,N-dinitramide anion N(NO2)2− following admixture with the N,N-dinitramide salt. The biologically active cationic species may be a pharmacologically active cation, in which case the method is useful for enhancing the penetration of the blood-brain barrier by the pharmacologically active cation. In other embodiments, the ionizable compounds are medical imaging or diagnostic agents, or agricultural agents such as pesticides. Salts of biologically active cations and N,N-dinitramide ion are also provided as novel compositions of matter.Type: GrantFiled: July 13, 2001Date of Patent: December 21, 2004Assignee: SRI InternationalInventors: Jeffrey C. Bottaro, Mark A. Petrie, Paul E. Penwell, David C. Bomberger
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Publication number: 20040217047Abstract: This invention is directed to systems and methods for removing lipids from a fluid or from lipid-containing organisms from a fluid, such as plasma. These systems combine a fluid with at least one extraction solvent, which causes the lipids to separate from the fluid or from the lipid-containing organisms. The separated lipids are removed from the fluid. The at least one extraction solvent is removed from the fluid or at least reduced to a concentration enabling the fluid to be administered to a patient without undesirable consequences. Once the fluid has been processed, the fluid may be administered to a patient who donated the fluid or to a different patient for therapy.Type: ApplicationFiled: May 28, 2004Publication date: November 4, 2004Inventors: David C. Bomberger, Bryan Chavez, Pablo E. Garcia, Eric Hegwer, Thomas P. Low, Ripudaman Malhotra, Jeffrey J. Shimon
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Patent number: 6617064Abstract: The present invention features methods for preparing stabilized &agr;-AlH3 and &agr;′-AlH3, compositions containing these alane polymorphs, e.g., energetic compositions such as rocket propellants, and methods for using the novel polymorphs as chemical reducing agents, polymerization catalysts, and as a hydrogen source in fuel cells and batteries. The method produces stabilized alane by treating &agr;-AlH3 with an acidic solution that optionally contains a stabilizing agent such as an electron donor, an electron acceptor, or a compound which coordinates the Al3+ ion.Type: GrantFiled: March 29, 2001Date of Patent: September 9, 2003Assignee: SRI InternationalInventors: Mark A. Petrie, Jeffrey C. Bottaro, Robert J. Schmitt, Paul E. Penwell, David C. Bomberger
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Publication number: 20030150809Abstract: This invention is directed to systems and methods for removing lipids from a fluid or from lipid-containing organisms from a fluid, such as plasma. These systems combine a fluid with at least one extraction solvent, which causes the lipids to separate from the fluid or from the lipid-containing organisms. The separated lipids are removed from the fluid. The at least one extraction solvent is removed from the fluid or at least reduced to a concentration enabling the fluid to be administered to a patient without undesirable consequences. Once the fluid has been processed, the fluid may be administered to a patient who donated the fluid or to a different patient for therapy.Type: ApplicationFiled: June 21, 2002Publication date: August 14, 2003Inventors: David C. Bomberger, Bryan Chavez, Pablo E. Garcia, Eric Hegwer, Thomas P. Low, Ripudaman Malhotra, Jeffrey J. Shimon
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Publication number: 20030127386Abstract: This invention is directed to systems and methods for removing lipids from a fluid, such as plasma, or from lipid-containing organisms. These systems contact a fluid with an extraction solvent, which causes the lipids in the fluid to separate from the fluid or causes lipids in the lipid-containing organisms to separate from the lipid-containing organism, using at least one hollow fiber contactor. The separated lipids are removed from the fluid. The extraction solvent is removed from the fluid or at least reduced to a level below a particular threshold enabling the fluid to be administered to a patient without the patient experiencing undesirable consequences. Once the fluid has been processed, the fluid may be administered to a patient who donated the fluid, to a different patient, or be stored.Type: ApplicationFiled: June 21, 2002Publication date: July 10, 2003Inventors: David C. Bomberger, Pablo E. Garcia, Eric Hegwer, Thomas P. Low, Ripudaman Malhotra
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Publication number: 20030104350Abstract: Systems and methods for removing lipids from a fluid, such as plasma, or from lipid-containing organisms. A fluid is combined with at least one extraction solvent, which causes the lipids to separate from the fluid or from lipid-containing organisms. The separated lipids are removed from the fluid. The extraction solvent is removed from the fluid or at least reduced to an acceptable concentration enabling the delipidated fluid to be administered to a patient without the patient experiencing undesirable consequences. Once the fluid has been processed, the fluid may be administered to a patient who donated the fluid, to a different patient, or stored for later use.Type: ApplicationFiled: June 21, 2002Publication date: June 5, 2003Inventors: David C. Bomberger, Bryan Chavez, Pablo E. Garcia, Eric Hegwer, Thomas P. Low, Ripudaman Malholtra, Jeffrey J. Shimon
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Publication number: 20030091649Abstract: Method and system of producing microparticles loaded with biologically active drugs, including proteins such as ICAM-1, for controlled release of the drugs in a nasal passageway. The method includes introducing a drug/polymer feed solution and an emulsifier into a first mixing chamber to create an emulsion, then mixing a cross-linking agent together with the emulsion under controlled conditions to create microparticles loaded with the drug. The system includes a first mixing chamber, in which the emulsion is created, having a first port for introducing the drug/polymer solution, and a second port angled substantially perpendicular to the first port for introducing the emulsifier. A second mixing chamber adjacent to the first mixing chamber receives the emulsion and either contains a cross-linking agent or receives a stream of a cross-linking agent to solidify the microparticles.Type: ApplicationFiled: April 22, 2002Publication date: May 15, 2003Inventors: David C. Bomberger, Paul G. Catz, Mark I. Smedley, Paul C. Stearns