Abstract: Implantable subcutaneous drug delivery devices for treating chronic nerve pain, and methods of use thereof, are disclosed. The device includes a reservoir having a septum, and a flexible tube in fluid flow communication with the reservoir, with at least a portion of the tube having a plurality of sidewall apertures. The device is implanted such that the apertures are disposed proximal to the desired tissue for contacting the desired tissue with medicine, and the reservoir is disposed in an unobtrusive location distal from the desired tissue. Medicine is periodically and repeatedly percutaneously charged to the device via a cannula introduced from outside the body.