Patents by Inventor David C. Dale

David C. Dale has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • USE OF CXCR4 ANTAGONISTS
    Publication number: 20210161859
    Abstract: Presently disclosed are methods and compositions for treating or preventing WHIM syndrome and certain other disorders or conditions with a certain CXCR4 antagonist.
    Type: Application
    Filed: July 13, 2020
    Publication date: June 3, 2021
    Inventors: David C. DALE, Gary J. BRIDGER, Frank J. HSU
  • METHODS TO MOBILIZE PROGENITOR/STEM CELLS
    Publication number: 20190216773
    Abstract: Methods to elevate progenitor and stem cell counts in animal subjects using compounds which bind to the chemokine receptor CXCR4 are disclosed.
    Type: Application
    Filed: August 21, 2018
    Publication date: July 18, 2019
    Inventors: Gary J. BRIDGER, Michael J. ABRAMS, Geoffrey W. HENSON, Ronald Trevor MACFARLAND, Gary B. CALANDRA, Hal E. BROXMEYER, David C. DALE
  • METHODS TO MOBILIZE PROGENITOR/STEM CELLS
    Publication number: 20170049747
    Abstract: Methods to elevate progenitor and stem cell counts in animal subjects using compounds which bind to the chemokine receptor CXCR4 are disclosed.
    Type: Application
    Filed: March 18, 2016
    Publication date: February 23, 2017
    Inventors: Gary J. BRIDGER, Michael J. ABRAMS, Geoffrey W. HENSON, Ronald Trevor MACFARLAND, Gary B. CALANDRA, Hal E. BROXMEYER, David C. DALE
  • METHODS TO MOBILIZE PROGENITOR/STEM CELLS
    Publication number: 20150246019
    Abstract: Methods to elevate progenitor and stem cell counts in animal subjects using compounds which bind to the chemokine receptor CXCR4 are disclosed.
    Type: Application
    Filed: October 3, 2014
    Publication date: September 3, 2015
    Inventors: Gary J. BRIDGER, Michael J. Abrams, Geoffrey W. Henson, Ronald Trevor Macfarland, Gary B. Calandra, Hal E. Broxmeyer, David C. Dale
  • Use of CXCR4 Antagonists
    Publication number: 20150030561
    Abstract: Presently disclosed are methods and compositions for treating or preventing WHIM syndrome and certain other disorders or conditions with a certain CXCR4 antagonist.
    Type: Application
    Filed: May 15, 2012
    Publication date: January 29, 2015
    Applicants: GENZYME CORP., UNIVERSITY OF WASHINGTON CENTER FOR COMMERCIALIZATION
    Inventors: David C. Dale, Gary J. Bridger, Frank J. Hsu
  • Method of treating inherited severe neutropenia
    Patent number: 8283344
    Abstract: The invention is directed to a method of treating severe neutropenia, and in particular, cyclic neutropenia (CN) or severe congenital neutropenia (SCN), in a patient in need of such treatment comprising: administering a therapeutically effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: September 5, 2008
    Date of Patent: October 9, 2012
    Assignees: Merck & Co., Inc., University of Washington
    Inventors: David C. Dale, Paul E. Finke, Richard A. Mumford, Andranik Andrew Aprikyan
  • METHODS TO MOBILIZE PROGENITOR/STEM CELLS
    Publication number: 20110129448
    Abstract: Methods to elevate progenitor and stem cell counts in animal subjects using compounds which bind to the chemokine receptor CXCR4 are disclosed.
    Type: Application
    Filed: February 8, 2011
    Publication date: June 2, 2011
    Applicant: Genzyme Corporation
    Inventors: Gary J. BRIDGER, Michael J. Abrams, Geoffrey W. Henson, Ronald Trevor MacFarland, Gary B. Calandra, Hal E. Broxmeyer, David C. Dale
  • Methods to mobilize progenitor/stem cells
    Patent number: 7935692
    Abstract: Methods to elevate progenitor and stem cell counts in animal subjects using compounds which bind to the chemokine receptor CXCR4 are disclosed.
    Type: Grant
    Filed: November 8, 2005
    Date of Patent: May 3, 2011
    Assignee: Genzyme Corporation
    Inventors: Gary J. Bridger, Michael J. Abrams, Geoffrey W. Henson, Ronald Trevor MacFarland, Gary B. Calandra, Hal E. Broxmeyer, David C. Dale
  • METHOD OF TREATING INHERITED SEVERE NEUTROPENIA
    Publication number: 20110059960
    Abstract: The invention is directed to a method of treating severe neutropenia, and in particular, cyclic neutropenia (CN) or severe congenital neutropenia (SCN), in a patient in need of such treatment comprising: administering a therapeutically effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: September 5, 2008
    Publication date: March 10, 2011
    Inventors: David C. Dale, Paul E. Finke, Richard A. Munford, Andranik Andrew Aprikyan
  • Methods to mobilize progenitor/stem cells
    Patent number: 7897590
    Abstract: Methods to elevate progenitor and stem cell counts in animal subjects using compounds which bind to the chemokine receptor CXCR4 are disclosed.
    Type: Grant
    Filed: August 20, 2007
    Date of Patent: March 1, 2011
    Assignee: Genzyme Corporation
    Inventors: Gary J. Bridger, Michael J. Abrams, Geoffrey W. Henson, Ronald Trevor MacFarland, Gary B. Calandra, Hal E. Broxmeyer, David C. Dale
  • Methods to mobilize progenitor/stem cells
    Patent number: 6987102
    Abstract: Certain nitrogen-containing compounds that bind the chemokine receptor CXCR4 are able to mobilize progenitor and/or stem cells into the peripheral blood to permit harvesting them for stem cell transplantation.
    Type: Grant
    Filed: July 30, 2002
    Date of Patent: January 17, 2006
    Assignee: Anormed, Inc.
    Inventors: Gary J. Bridger, Michael J. Abrams, Geoffrey W. Henson, Ronald Trevor MacFarland, Gary B. Calandra, Hal E. Broxmeyer, David C. Dale
  • Devices and methods for implanting transduced cells
    Publication number: 20040156833
    Abstract: Vascular grafts are used in gene therapy to implant autologous vascular smooth muscle cells that have been transduced with the gene of interest. The smooth muscle cells are immobilized within the pores and upon the interior surface of the wall of the graft, which is then coated with vascular endothelial cells and implanted into a patients's vascular system. The grafting device can be used in methods of treatment, such as supplying erythropoietin to a patient, and can be removed easily and replenished as necessary. The process is readily controlled and significantly reduces the risk of a viral gene vector spreading beyond a target cell population.
    Type: Application
    Filed: January 26, 2004
    Publication date: August 12, 2004
    Applicant: University of Washington
    Inventors: William R. A. Osborne, Randolph L. Geary, Stella Lau, Alexander W. Clowes, David C. Dale