Patents by Inventor David C. Diamond

David C. Diamond has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20080124352
    Abstract: Embodiments of the invention disclosed herein relate to methods and compositions for bypassing the involvement of CD4+ cells when generating antibody and MHC class I-restricted immune responses, controlling the nature and magnitude of the response, and promoting effective immunologic intervention in viral pathogenesis. More specifically, embodiments relate to immunogenic compositions for vaccination particularly therapeutic vaccination, against HIV and other microbial pathogens that impact functioning of the immune system, their nature, and the order, timing, and route of administration by which they are effectively used.
    Type: Application
    Filed: December 29, 2005
    Publication date: May 29, 2008
    Inventors: David C. Diamond, Adrian Ion Bot
  • Patent number: 7252824
    Abstract: Disclosed herein are immunogenic compositions, methods of designing immunogenic compositions, methods of treatment using immunogenic compositions, methods of evaluating cell-mediated immunity resulting from immunogenic compositions, research models, and methods of making research models, all of which relate to targeting tumor vasculature.
    Type: Grant
    Filed: March 7, 2002
    Date of Patent: August 7, 2007
    Assignee: Mannkind Corporation
    Inventors: John J. L. Simard, David C. Diamond
  • Patent number: 7232682
    Abstract: The invention disclosed herein is directed to methods of identifying a polypeptide suitable for epitope liberation including, for example, the steps of identifying an epitope of interest; providing a substrate polypeptide sequence including the epitope, wherein the substrate polypeptide permits processing by a proteasome; contacting the substrate polypeptide with a composition including the proteasome, under conditions that support processing of the substrate polypeptide by the proteasome; and assaying for liberation of the epitope. The invention further relates to vectors including a housekeeping epitope expression cassette and also vectors including epitope cluster regions. The housekeeping epitope(s) can be derived from a target-associated antigen. The housekeeping epitope can be liberatable, that is capable of liberation, from a translation product of the cassette by immunoproteasome processing.
    Type: Grant
    Filed: February 10, 2004
    Date of Patent: June 19, 2007
    Assignee: Mannkind Corporation
    Inventors: John J. L. Simard, David C. Diamond, Zhiyong Qiu, Xiang-Dong Lei
  • Patent number: 6861234
    Abstract: A method of epitope discovery comprising the step of selecting an epitope from a population of peptide fragments of an antigen associated with a target cell, wherein the fragments have a known or predicted affinity for a major histocompatibility complex class I receptor peptide binding cleft, wherein the epitope selected corresponds to a proteasome cleavage product of the target cell.
    Type: Grant
    Filed: April 28, 2000
    Date of Patent: March 1, 2005
    Assignee: MannKind Corporation
    Inventors: John J. L. Simard, David C. Diamond
  • Publication number: 20040203051
    Abstract: The invention disclosed herein is directed to methods of identifying a polypeptide suitable for epitope liberation including, for example, the steps of identifying an epitope of interest; providing a substrate polypeptide sequence including the epitope, wherein the substrate polypeptide permits processing by a proteasome; contacting the substrate polypeptide with a composition including the proteasome, under conditions that support processing of the substrate polypeptide by the proteasome; and assaying for liberation of the epitope. The invention further relates to vectors including a housekeeping epitope expression cassette. The invention relates to epitope cluster regions and to vectors including epitope cluster regions. The invention also relates to a method of activating a T cell comprising contacting a substrate polypeptide with an APC and contacting the APC with a T cell.
    Type: Application
    Filed: April 30, 2004
    Publication date: October 14, 2004
    Inventors: John J.L. Simard, David C. Diamond, Zhiyong Qiu, Xiang-Dong Lei
  • Publication number: 20040180354
    Abstract: Disclosed herein are polypeptides, including epitopes, clusters, and antigens. Also disclosed are compositions that include said polypeptides and methods for their use.
    Type: Application
    Filed: September 5, 2003
    Publication date: September 16, 2004
    Inventors: John J.L. Simard, David C. Diamond, Liping Liu, Zheng Liu
  • Publication number: 20040132088
    Abstract: The invention disclosed herein is directed to methods of identifying a polypeptide suitable for epitope liberation including, for example, the steps of identifying an epitope of interest; providing a substrate polypeptide sequence including the epitope, wherein the substrate polypeptide permits processing by a proteasome; contacting the substrate polypeptide with a composition including the proteasome, under conditions that support processing of the substrate polypeptide by the proteasome; and assaying for liberation of the epitope. The invention further relates to vectors including a housekeeping epitope expression cassette and also vectors including epitope cluster regions. The housekeeping epitope(s) can be derived from a target-associated antigen. The housekeeping epitope can be liberatable, that is capable of liberation, from a translation product of the cassette by immunoproteasome processing.
    Type: Application
    Filed: February 10, 2004
    Publication date: July 8, 2004
    Inventors: John J.L. Simard, David C. Diamond, Zhiyong Qiu, Xiang-Dong Lei
  • Publication number: 20030228634
    Abstract: The invention disclosed herein is directed to methods of identifying a polypeptide suitable for epitope liberation including, for example, the steps of identifying an epitope of interest; providing a substrate polypeptide sequence including the epitope, wherein the substrate polypeptide permits processing by a proteasome; contacting the substrate polypeptide with a composition including the proteasome, under conditions that support processing of the substrate polypeptide by the proteasome; and assaying for liberation of the epitope. The invention further relates to vectors including a housekeeping epitope expression cassette. The housekeeping epitope(s) can be derived from a target-associated antigen, and the housekeeping epitope can be liberatable, that is capable of liberation, from a translation product of the cassette by immunoproteasome processing. The invention also relates to a method of activating a T cell comprising contacting a substrate polypeptide with an APC and contacting the APC with a T cell.
    Type: Application
    Filed: November 7, 2002
    Publication date: December 11, 2003
    Inventors: John J.L. Simard, David C. Diamond, Zhiyong Qiu, Xiang-Dong Lei
  • Publication number: 20030220239
    Abstract: Disclosed herein are polypeptides, including epitopes, clusters, and antigens. Also disclosed are compositions that include said polypeptides and methods for their use.
    Type: Application
    Filed: April 4, 2002
    Publication date: November 27, 2003
    Inventors: John J. L. Simard, David C. Diamond, Liping Liu, Zhidong Xie
  • Publication number: 20030215425
    Abstract: Disclosed herein are vaccines and methods for inducing an immune response against cancer cells and cells infected with intracellular parasites. Vaccines having housekeeping epitopes are disclosed. The housekeeping epitope is formed by housekeeping proteasomes in peripheral cells, but not by professional antigen presenting cells. A vaccine containing a housekeeping epitope that is derived from an antigen associated with a peripheral target cell can thus direct an immune response against the target cell. Methods of treatment are also disclosed, which involve administering a vaccine having a housekeeping epitope.
    Type: Application
    Filed: December 7, 2001
    Publication date: November 20, 2003
    Inventors: John J. L. Simard, David C. Diamond
  • Publication number: 20030138808
    Abstract: The invention provides a nucleic acid construct encoding a housekeeping epitope derived from an antigen associated with a target cell. The construct can further include a second sequence encoding a housekeeping epitope or an immune epitope. The construct can be used as a vaccine against numerous kinds of target cells, including neoplastic cells and cells infected with an intracellular virus.
    Type: Application
    Filed: August 20, 2002
    Publication date: July 24, 2003
    Inventors: John J.L. Simard, Xiang-Dong Lei, David C. Diamond
  • Publication number: 20030046714
    Abstract: Disclosed herein are immunogenic compositions, methods of designing immunogenic compositions, methods of treatment using immunogenic compositions, methods of evaluating cell-mediated immunity resulting from immunogenic compositions, research models, and methods of making research models, all of which relate to targeting tumor vasculature.
    Type: Application
    Filed: March 7, 2002
    Publication date: March 6, 2003
    Inventors: John J.L. Simard, David C. Diamond